公开(公告)号：US11420978B2

公开(公告)日：2022-08-23

申请号：US17044481

申请日：2019-04-03

申请人： GLACEUM INC.

发明人： Sang Ku Yoo ,  Jin Wook Chung ,  In Geun Jo ,  Ji Young Kim ,  Jeong Ho Im ,  Ku Suk Kang ,  Jin Young Kim

IPC分类号： C07D493/04

摘要： The present invention relates to a method for synthesizing a 3-phenyl-2,8-dihydropyrano[2,3-f]chromene derivative, which may be usefully used for synthesizing a pyranochromenyl phenol derivative, and when the derivative is used, the 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative may be effectively prepared.

公开(公告)号：US09783551B2

公开(公告)日：2017-10-10

申请号：US15037230

申请日：2014-12-23

申请人： GLACEUM, INC.

发明人： Sang Ku Yoo ,  Jin Wook Chung ,  In Geun Jo ,  Jeong Ho Im ,  Ku Suk Kang ,  Jin Young Kim

IPC分类号： C07D493/00 ,  C07D497/04 ,  C07D493/04

CPC分类号： C07D497/04 ,  C07D493/04

摘要： Provided are a pyranochromenyl phenol derivative, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical composition for preventing or treating metabolic syndrome or inflammatory disease comprising same.The present invention is efficacious in preventing or treating metabolic syndrome or inflammatory disease and is chemically stable.

公开(公告)号：US11332475B2

公开(公告)日：2022-05-17

申请号：US17114584

申请日：2020-12-08

申请人： GLACEUM, INC.

发明人： Sang Ku Yoo ,  Jin Wook Chung ,  In Geun Jo ,  Ji Young Kim ,  Jeong Ho Im ,  Ku Suk Kang ,  Jin Young Kim

IPC分类号： A61K31/353 ,  C07D493/04 ,  A61K31/352 ,  A61P3/04 ,  C07B57/00

摘要： The present invention relates to pyranochromenylphenol derivatives having different efficacies depending on the direction of optical activity and a pharmaceutical composition including the same, and in the pyranochromenylphenol derivatives, an R-enantiomer has excellent anti-diabetic efficacy by suppressing a rise in blood sugar and an S-enantiomer has excellent anti-obesity efficacy by suppressing an increase in body weight.

公开(公告)号：US10947250B2

公开(公告)日：2021-03-16

申请号：US16807218

申请日：2020-03-03

申请人： GLACEUM, INC.

发明人： Sang Ku Yoo ,  Jin Wook Chung ,  In Geun Jo ,  Ji Young Kim ,  Jeong Ho Im ,  Ku Suk Kang ,  Jin Young Kim

IPC分类号： C07D493/04 ,  C07D311/04

摘要： The present invention relates to a method for synthesizing a 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and an optical isomer thereof, and an intermediate Compound which may be used for the synthesis method, and when the method and the intermediate Compound are used, the 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and the optical isomer thereof may be effectively synthesized.

公开(公告)号：US10669282B2

公开(公告)日：2020-06-02

申请号：US16339288

申请日：2017-09-27

申请人： GLACEUM, INC.

发明人： Sang Ku Yoo ,  Jin Wook Chung ,  In Geun Jo ,  Ji Young Kim ,  Jeong Ho Im ,  Ku Suk Kang ,  Jin Young Kim

IPC分类号： C07D493/04 ,  C07D311/04

摘要： The present invention relates to a method for synthesizing a 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and an optical isomer thereof, and an intermediate Compound which may be used for the synthesis method, and when the method and the intermediate Compound are used, the 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and the optical isomer thereof may be effectively synthesized.