公开(公告)号：US11332475B2

公开(公告)日：2022-05-17

申请号：US17114584

申请日：2020-12-08

申请人： GLACEUM, INC.

发明人： Sang Ku Yoo ,  Jin Wook Chung ,  In Geun Jo ,  Ji Young Kim ,  Jeong Ho Im ,  Ku Suk Kang ,  Jin Young Kim

IPC分类号： A61K31/353 ,  C07D493/04 ,  A61K31/352 ,  A61P3/04 ,  C07B57/00

摘要： The present invention relates to pyranochromenylphenol derivatives having different efficacies depending on the direction of optical activity and a pharmaceutical composition including the same, and in the pyranochromenylphenol derivatives, an R-enantiomer has excellent anti-diabetic efficacy by suppressing a rise in blood sugar and an S-enantiomer has excellent anti-obesity efficacy by suppressing an increase in body weight.

公开(公告)号：US11420978B2

公开(公告)日：2022-08-23

申请号：US17044481

申请日：2019-04-03

申请人： GLACEUM INC.

发明人： Sang Ku Yoo ,  Jin Wook Chung ,  In Geun Jo ,  Ji Young Kim ,  Jeong Ho Im ,  Ku Suk Kang ,  Jin Young Kim

IPC分类号： C07D493/04

摘要： The present invention relates to a method for synthesizing a 3-phenyl-2,8-dihydropyrano[2,3-f]chromene derivative, which may be usefully used for synthesizing a pyranochromenyl phenol derivative, and when the derivative is used, the 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative may be effectively prepared.

公开(公告)号：US11420988B2

公开(公告)日：2022-08-23

申请号：US17281652

申请日：2019-10-02

申请人： GLACEUM INC.

发明人： Sang Ku Yoo ,  Ku Suk Kang ,  Jin Young Kim ,  Jung Woo Lee ,  Ji Young Kim ,  Jeong Ho Im

IPC分类号： C07F15/00 ,  B01J31/02 ,  B01J31/18 ,  B01J31/22

摘要： The present invention may provide an asymmetric hydrogenation catalyst capable of resolving enantiomers with excellent enantioselectivity from a carbon-carbon double bond-containing compound. The catalyst according to one embodiment of the present invention includes: an iridium cation; and a ligand bonded to the iridium cation.

公开(公告)号：US10947250B2

公开(公告)日：2021-03-16

申请号：US16807218

申请日：2020-03-03

申请人： GLACEUM, INC.

发明人： Sang Ku Yoo ,  Jin Wook Chung ,  In Geun Jo ,  Ji Young Kim ,  Jeong Ho Im ,  Ku Suk Kang ,  Jin Young Kim

IPC分类号： C07D493/04 ,  C07D311/04

摘要： The present invention relates to a method for synthesizing a 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and an optical isomer thereof, and an intermediate Compound which may be used for the synthesis method, and when the method and the intermediate Compound are used, the 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and the optical isomer thereof may be effectively synthesized.

公开(公告)号：US10669282B2

公开(公告)日：2020-06-02

申请号：US16339288

申请日：2017-09-27

申请人： GLACEUM, INC.

发明人： Sang Ku Yoo ,  Jin Wook Chung ,  In Geun Jo ,  Ji Young Kim ,  Jeong Ho Im ,  Ku Suk Kang ,  Jin Young Kim

IPC分类号： C07D493/04 ,  C07D311/04

摘要： The present invention relates to a method for synthesizing a 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and an optical isomer thereof, and an intermediate Compound which may be used for the synthesis method, and when the method and the intermediate Compound are used, the 3-phenyl-2,3,4,8,9,10-hexahydropyrano[2,3-f]chromene derivative and the optical isomer thereof may be effectively synthesized.