公开(公告)号：US20180360949A1

公开(公告)日：2018-12-20

申请号：US16061729

申请日：2016-12-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Susan BARNETT ,  Marguerite Christine KOUTSOUKOS ,  Clarisse Marie-Madeleine LORIN ,  Frederick PORTER ,  Zihao WANG ,  Ying ZHANG

IPC: A61K39/21 ,  A61K39/295 ,  C07K14/16

Abstract: The invention provides, inter alia, compositions useful for, e.g., raising an immune response to HIV-1, and associated methods of raising an immune response to HIV in a mammalian subject. In some embodiments, the compositions are bivalent immunogenic compositions comprising two (or, in some embodiments more than two) human immunodeficiency virus (HIV) clade C envelope gp120 polypeptide antigens, together with a liposome-based adjuvant, such as the adjuvant known as AS01.