公开(公告)号：US20210290755A1

公开(公告)日：2021-09-23

申请号：US17330826

申请日：2021-05-26

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Andrew GEALL ,  Gillis OTTEN ,  Susan BARNETT

IPC: A61K39/155 ,  A61K39/245 ,  A61K39/12 ,  A61P31/20 ,  A61P31/14

Abstract: This invention generally relates to immunogenic compositions that comprise an RNA component and a polypeptide component. Immunogenic compositions that deliver antigenic epitopes in two different forms—a first epitope from a pathogen, in RNA-coded form; and a second epitope from the same pathogen, in polypeptide form—are effective in inducing immune response to the pathogen. The invention also relates to a kit comprising an RNA-based priming composition and a polypeptide-based boosting composition. The kit may be used for sequential administration of the priming and the boosting compositions.

公开(公告)号：US20180360949A1

公开(公告)日：2018-12-20

申请号：US16061729

申请日：2016-12-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Susan BARNETT ,  Marguerite Christine KOUTSOUKOS ,  Clarisse Marie-Madeleine LORIN ,  Frederick PORTER ,  Zihao WANG ,  Ying ZHANG

IPC: A61K39/21 ,  A61K39/295 ,  C07K14/16

Abstract: The invention provides, inter alia, compositions useful for, e.g., raising an immune response to HIV-1, and associated methods of raising an immune response to HIV in a mammalian subject. In some embodiments, the compositions are bivalent immunogenic compositions comprising two (or, in some embodiments more than two) human immunodeficiency virus (HIV) clade C envelope gp120 polypeptide antigens, together with a liposome-based adjuvant, such as the adjuvant known as AS01.