公开(公告)号：US20210269486A1

公开(公告)日：2021-09-02

申请号：US16467569

申请日：2017-12-08

申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人： Virginia AMMENDOLA ,  Stefaano COLLOCA ,  Alessandra VITELLI ,  Benjamin Wizel

IPC分类号： C07K14/005 ,  A61K39/39 ,  A61K39/205 ,  C12N15/86 ,  A61P31/14 ,  A61K39/21 ,  A61P31/18 ,  A61K39/12

摘要： The invention provides adenoviral vectors comprising transgenes encoding Lyssaviral antigens. The vectors can be used to produce vaccines for the prophylaxis, amelioration and treatment of diseases caused by Lyssaviral diseases, e.g., rabies.

公开(公告)号：US20190300905A1

公开(公告)日：2019-10-03

申请号：US16466683

申请日：2017-12-07

申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人： Virginia AMMENDOLA ,  Stefania CAPONE ,  Stefano COLLOCA ,  Antonella FOLGORI ,  Rosella MERONE

IPC分类号： C12N15/86 ,  C07K14/005 ,  A61K39/21

摘要： The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.