公开(公告)号：US20240148849A1

公开(公告)日：2024-05-09

申请号：US18277843

申请日：2022-02-18

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Ashwani ARORA ,  Daniela CASULA ,  Mario CONTORNI ,  Fernando ULLOA-MONTOYA ,  Simona RONDINI ,  Tian SUN ,  Marco TESTA

IPC: A61K39/102 ,  A61K39/104 ,  A61P11/00

CPC classification number: A61K39/102 ,  A61K39/1045 ,  A61P11/00 ,  A61K2039/55572

Abstract: The present invention relates to the field of immunogenic compositions and the use of such compositions in medicine. More particularly, it relates to immunogenic compositions comprising an immunogenic polypeptide from non-typeable Haemophilus influenzae, a PE-PilA fusion protein, and optionally an immunogenic polypeptide of UspA2 from Moraxella catarrhalis, for use in subjects having chronic obstructive pulmonary disease (COPD), in particular for reducing the frequency of severe exacerbations (i.e. severe AECOPDs).