公开(公告)号：US20190290748A1

公开(公告)日：2019-09-26

申请号：US16363799

申请日：2019-03-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Marco SORIANI ,  Maria SCARSELLI ,  Nathalie NORAIS ,  Danilo GOMES MORIEL ,  Silvia ROSSI PACCANI

IPC: A61K39/102 ,  C07K14/285 ,  C12R1/21 ,  A61K39/02 ,  A61K39/095

Abstract: NTHI protein antigens have been identified and found to be conserved across several Haemophilus influenzae pathogenic strains. They have been isolated, cloned from a reference strain and tested for immunogenicity. Methods for immunization and vaccines derived thereof are also disclosed.