公开(公告)号：US20190290748A1

公开(公告)日：2019-09-26

申请号：US16363799

申请日：2019-03-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Marco SORIANI ,  Maria SCARSELLI ,  Nathalie NORAIS ,  Danilo GOMES MORIEL ,  Silvia ROSSI PACCANI

IPC: A61K39/102 ,  C07K14/285 ,  C12R1/21 ,  A61K39/02 ,  A61K39/095

Abstract: NTHI protein antigens have been identified and found to be conserved across several Haemophilus influenzae pathogenic strains. They have been isolated, cloned from a reference strain and tested for immunogenicity. Methods for immunization and vaccines derived thereof are also disclosed.

公开(公告)号：US20160067326A1

公开(公告)日：2016-03-10

申请号：US14786641

申请日：2014-04-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Maria ARICO ,  Giuseppe ERCOLI ,  Nathalie NORAIS ,  Marco SORIANI ,  Chiara TANI

IPC: A61K39/102 ,  C12R1/21

CPC classification number: A61K39/102 ,  A61K39/095 ,  A61K39/099 ,  A61K2039/55505 ,  A61K2039/55566 ,  C07K14/285 ,  C12R1/21 ,  Y02A50/466

Abstract: Gram-negative bacterial strains are generated by inactivating at least one LytM catalytic domain-containing protein, such as NT013, NT017 and NT022 of non typeable H influenzae. The vesicles from these strains are useful for vaccination.

Abstract translation: 通过灭活至少一种含有LytM催化结构域的蛋白质，例如不可流行H型流感嗜血杆菌的NT013，NT017和NT022，产生革兰氏阴性细菌菌株。 这些菌株的囊泡可用于疫苗接种。