公开(公告)号：US20180265551A1

公开(公告)日：2018-09-20

申请号：US15533483

申请日：2015-12-07

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Andrea CARFI ,  Sumana CHANDRAMOULI ,  Ethan C. SETTEMBRE

IPC: C07K14/005

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  C12N2710/16122 ,  C12N2710/16134

Abstract: The invention generally relates to recombinant human cytomegalovirus (CMV) gB proteins and immunogenic fragments thereof, which do not comprise a transmembrane (TM) domain; and comprise one or more mutations that reduce the aggregation between the monomeric trimers of gB, and/or adhesion of the monomeric trimer of gB to the host cell.