公开(公告)号：US10195263B2

公开(公告)日：2019-02-05

申请号：US15589834

申请日：2017-05-08

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Fabio Bagnoli ,  Massimiliano Biagini ,  Luigi Fiaschi ,  Guido Grandi ,  Ravi Pratap Narayan Mishra ,  Nathalie Norais ,  Maria Scarselli

IPC: A61K39/085 ,  C07K14/31 ,  A61K39/00

Abstract: An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.

公开(公告)号：US09926344B2

公开(公告)日：2018-03-27

申请号：US14420831

申请日：2013-08-29

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Fabio Bagnoli ,  Fabiana Falugi ,  Guido Grandi ,  Massimo Mariani ,  Mikkel Nissum ,  Michele Pallaoro ,  Silvana Savino

IPC: C07K14/31 ,  A61K39/085 ,  A61K39/00

CPC classification number: C07K14/31 ,  A61K39/085 ,  A61K2039/55505

Abstract: Elimination of disulphide bond formation of cysteine-containing S. aureus antigens enhances antigen stability. The invention provides variant forms of cysteine-containing S. aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.

公开(公告)号：US09642904B2

公开(公告)日：2017-05-09

申请号：US14961772

申请日：2015-12-07

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Fabio Bagnoli ,  Massimiliano Biagini ,  Luigi Fiaschi ,  Guido Grandi ,  Ravi Pratap Narayan Mishra ,  Nathalie Norais ,  Maria Scarselli

IPC: A61K39/085 ,  C07K14/31 ,  A61K39/00

CPC classification number: A61K39/085 ,  A61K39/00 ,  C07K14/31 ,  C07K2319/00

Abstract: An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.

公开(公告)号：US10328140B2

公开(公告)日：2019-06-25

申请号：US15127537

申请日：2015-03-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Fabio Bagnoli ,  Luigi Fiaschi ,  Maria Scarselli

IPC: A61K39/085 ,  A61K39/00 ,  A61K49/00 ,  C07K14/31

Abstract: Mutant protein A of Staphylococcus aureus (SpA) with decreased affinity for the Fcγ portion of human IgG is provided.

公开(公告)号：US11426455B2

公开(公告)日：2022-08-30

申请号：US16968895

申请日：2019-02-12

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Fabio Bagnoli ,  Carine Goraj

IPC: A61K39/385 ,  A61K39/09 ,  A61K39/085 ,  A61K45/00 ,  A61K47/00 ,  A61P31/04 ,  A61K39/00

Abstract: The invention provides an immunogenic composition comprising staphylococcal antigens, containing protein antigens and conjugates of capsular polysaccharides, n particular Hla, ClfA, SpA and conjugates of capsular polysaccharides. Adjuvanted formulations are also provided. The invention may find use in the prevention and treatment of staphylococcal infections, in particular S. aureus infection and disease.