公开(公告)号：US20210207171A1

公开(公告)日：2021-07-08

申请号：US17251518

申请日：2019-06-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Frédéric Stéphane MATHOT ,  Mathieu VASSELLE

IPC: C12N15/86 ,  C07K14/765 ,  A61K47/26

Abstract: The invention relates to liquid formulations of simian adenoviruses and methods for obtaining the formulations. The formulations comprise an amorphous sugar, Vitamin E succinate and recombinant human serum albumin in a buffered solution.

公开(公告)号：US20230066762A1

公开(公告)日：2023-03-02

申请号：US17632299

申请日：2020-08-03

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Ghislain DELPIERRE ,  Juliette FORTPIED ,  Virginie HELLEBAUT ,  Vincent Edwin Paul LEVET ,  Roland MAINIL ,  Frédéric Stéphane MATHOT ,  Maria Dolores MORALES AIRA ,  Philippe SCIEUR ,  Bram VUYLSTEKE

IPC: A61K39/145 ,  A61K39/104 ,  A61K47/20 ,  A61K47/10 ,  A61K47/26

Abstract: The present invention relates to immunogenic compositions comprising immunogenic polypeptides from Haemophilus influenzae and Moraxella catarrhalis and their use in the treatment or prevention of an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a subject, e.g. human.

公开(公告)号：US20210283238A1

公开(公告)日：2021-09-16

申请号：US17265872

申请日：2019-08-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Vincent Edwin Paul LEVET ,  Frédéric Stéphane MATHOT ,  Bram VUYLSTEKE

IPC: A61K39/12 ,  C12N7/00

Abstract: A method of manufacturing a biological medicament comprising at least one biological molecule or vector is provided. One or more steps of the method are performed in an aseptic enclosure which has been surfaced sterilized using hydrogen peroxide, the steps including: formulating the biological molecule or vector with one or more excipients including an antioxidant, to produce a biological medicament comprising an antioxidant; filling containers with the biological medicament; and sealing or partially sealing the containers. Methods may be used to manufacture biological medicaments, immunogenic compositions and vaccines comprising antioxidants.