公开(公告)号：US20220288190A1

公开(公告)日：2022-09-15

申请号：US17632270

申请日：2020-08-03

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Pierre SAE HOUER ,  Pedro SANTANA DOS SANTOS ,  Laurent Bernard Jean STRODIOT ,  Bram VUYLSTEKE ,  Arnaud ZULIANI

IPC: A61K39/145 ,  A61K47/26 ,  A61K47/10 ,  A61K39/07 ,  A61K39/104 ,  A61K47/02

Abstract: The present invention relates to a process for preparing immunogenic compositions. More particularly, it relates to a process for preparing liquid compositions of Protein D polypeptide and their use in preparing immunogenic compositions comprising Protein D polypeptide which may be used in the treatment or prevention of an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a subject, e.g. human.

公开(公告)号：US20240131140A1

公开(公告)日：2024-04-25

申请号：US18276578

申请日：2022-02-09

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA ,  XIAMEN INNOVAX BIOTECH CO., LTD.

Inventor： Babak BAYAT ,  Véronique HENDERICKX ,  Bram VUYLSTEKE

IPC: A61K39/12

CPC classification number: A61K39/12 ,  A61K2039/55505 ,  C12N2710/20034

Abstract: Described are methods for the preparation of a HPV vaccine composition by, for example (i) adsorbing one or more HPV antigen(s) on a metallic salt and, then (ii) adding a non adsorbed glycolipid based TLR4 ligand to the mixture obtained in (i). Resulting HPV vaccine compositions and uses thereof are also described.

公开(公告)号：US20230248816A9

公开(公告)日：2023-08-10

申请号：US17632270

申请日：2020-08-03

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Pierre SAE HOUER ,  Pedro SANTANA DOS SANTOS ,  Laurent Bernard Jean STRODIOT ,  Bram VUYLSTEKE ,  Arnaud ZULIANI

IPC: A61K39/145 ,  A61K47/26 ,  A61K47/10 ,  A61K39/07 ,  A61K39/104 ,  A61K47/02

CPC classification number: A61K39/145 ,  A61K47/26 ,  A61K47/10 ,  A61K39/07 ,  A61K39/1045 ,  A61K47/02

Abstract: The present invention relates to a process for preparing immunogenic compositions. More particularly, it relates to a process for preparing liquid compositions of Protein D polypeptide and their use in preparing immunogenic compositions comprising Protein D polypeptide which may be used in the treatment or prevention of an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a subject, e.g. human.

公开(公告)号：US20230066762A1

公开(公告)日：2023-03-02

申请号：US17632299

申请日：2020-08-03

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Ghislain DELPIERRE ,  Juliette FORTPIED ,  Virginie HELLEBAUT ,  Vincent Edwin Paul LEVET ,  Roland MAINIL ,  Frédéric Stéphane MATHOT ,  Maria Dolores MORALES AIRA ,  Philippe SCIEUR ,  Bram VUYLSTEKE

IPC: A61K39/145 ,  A61K39/104 ,  A61K47/20 ,  A61K47/10 ,  A61K47/26

Abstract: The present invention relates to immunogenic compositions comprising immunogenic polypeptides from Haemophilus influenzae and Moraxella catarrhalis and their use in the treatment or prevention of an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in a subject, e.g. human.

公开(公告)号：US20210283238A1

公开(公告)日：2021-09-16

申请号：US17265872

申请日：2019-08-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Vincent Edwin Paul LEVET ,  Frédéric Stéphane MATHOT ,  Bram VUYLSTEKE

IPC: A61K39/12 ,  C12N7/00

Abstract: A method of manufacturing a biological medicament comprising at least one biological molecule or vector is provided. One or more steps of the method are performed in an aseptic enclosure which has been surfaced sterilized using hydrogen peroxide, the steps including: formulating the biological molecule or vector with one or more excipients including an antioxidant, to produce a biological medicament comprising an antioxidant; filling containers with the biological medicament; and sealing or partially sealing the containers. Methods may be used to manufacture biological medicaments, immunogenic compositions and vaccines comprising antioxidants.