公开(公告)号：US11932669B2

公开(公告)日：2024-03-19

申请号：US17223207

申请日：2021-04-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Enrico Malito ,  Matthew James Bottomley ,  Andrea Carfi ,  Sumana Chandramouli ,  Kate Luisi

IPC: C07K14/045 ,  A61K38/00 ,  A61K39/245

CPC classification number: C07K14/045 ,  A61K39/245 ,  A61K38/00

Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.