公开(公告)号：US11932669B2

公开(公告)日：2024-03-19

申请号：US17223207

申请日：2021-04-06

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Enrico Malito ,  Matthew James Bottomley ,  Andrea Carfi ,  Sumana Chandramouli ,  Kate Luisi

IPC: C07K14/045 ,  A61K38/00 ,  A61K39/245

CPC classification number: C07K14/045 ,  A61K39/245 ,  A61K38/00

Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.

公开(公告)号：US11932671B2

公开(公告)日：2024-03-19

申请号：US17245681

申请日：2021-04-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew Bottomley ,  Enrico Malito ,  Manuele Martinelli ,  Maria Scarselli

IPC: A61P37/04 ,  A61K39/095 ,  C07K14/22 ,  A61K39/00

CPC classification number: C07K14/22 ,  A61K39/095 ,  A61K2039/523 ,  A61K2039/55511 ,  A61K2039/70

Abstract: Modified meningococcal fHbp polypeptides with increased stability.

公开(公告)号：US11021522B2

公开(公告)日：2021-06-01

申请号：US16458365

申请日：2019-07-01

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew Bottomley ,  Enrico Malito ,  Manuele Martinelli ,  Maria Scarselli

IPC: A61P37/04 ,  C07K14/22 ,  A61K39/095 ,  A61K39/00

Abstract: Modified meningococcal fHbp polypeptides with increased stability.

公开(公告)号：US10392424B2

公开(公告)日：2019-08-27

申请号：US15120674

申请日：2015-02-27

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Matthew Bottomley ,  Enrico Malito ,  Manuele Martinelli ,  Maria Scarselli

IPC: A61K39/095 ,  C07K14/22 ,  A61K39/00

Abstract: Modified meningococcal fHbp polypeptides with increased stability.