公开(公告)号：US11274115B2

公开(公告)日：2022-03-15

申请号：US16330599

申请日：2017-09-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Helene G. Bazin-Lee ,  Jay T. Evans ,  David Burkhart ,  Michael Cochran ,  David A. Johnson

IPC: C07F9/6561

Abstract: This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.

公开(公告)号：US11207404B2

公开(公告)日：2021-12-28

申请号：US16848910

申请日：2020-04-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： David Burkhart ,  Michael Cochran ,  Christopher W Cluff ,  Daniel Larocque ,  Helene G. Bazin-Lee ,  Julien St-Jean

IPC: A61K31/522 ,  A61K39/39 ,  A61K31/52 ,  A61K39/00

Abstract: The present invention relates to immunogenic compositions and methods for producing them, and in particular, immunogenic compositions comprising a protein antigen cross linked to an oxoadenine adjuvant.

公开(公告)号：US10646566B2

公开(公告)日：2020-05-12

申请号：US15556520

申请日：2016-03-09

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： David Burkhart ,  Michael Cochran ,  Christopher W Cluff ,  Daniel Larocque ,  Helene G Bazin-Lee ,  Julien St Jean

IPC: A61K39/39 ,  A61K31/522 ,  A61K31/52 ,  A61K39/00

Abstract: The present invention relates to immunogenic compositions and methods for producing them, and in particular, immunogenic compositions comprising a protein antigen cross linked to an oxoadenine adjuvant.