公开(公告)号：US10307374B2

公开(公告)日：2019-06-04

申请号：US15495066

申请日：2017-04-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Luis Brito ,  Michelle C. Archer ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

IPC: A61K9/107 ,  A61K39/12 ,  A61K39/155 ,  A61K31/713 ,  A61K9/00 ,  A61K39/00

Abstract: This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.