公开(公告)号：US10307374B2

公开(公告)日：2019-06-04

申请号：US15495066

申请日：2017-04-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Luis Brito ,  Michelle C. Archer ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

IPC: A61K9/107 ,  A61K39/12 ,  A61K39/155 ,  A61K31/713 ,  A61K9/00 ,  A61K39/00

Abstract: This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.

公开(公告)号：US10098949B2

公开(公告)日：2018-10-16

申请号：US15093652

申请日：2016-04-07

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Manmohan Singh ,  David A. G. Skibinksi ,  Tom Yao-Hsiang Wu ,  Yongkai Li ,  Alex Cortez ,  Xiaoyue Zhang ,  Yefen Zou ,  Timothy Z. Hoffman ,  Jianfeng Pan ,  Kathy Yue

IPC: C07D471/04 ,  A61K39/39 ,  A61K31/661 ,  A61K31/6615 ,  A61K31/662 ,  A61K39/095 ,  C07D487/04 ,  C07F9/645 ,  C07F9/6512 ,  C07F9/6558 ,  C07F9/6561 ,  A61K39/02 ,  A61K39/05 ,  A61K39/08 ,  A61K39/09 ,  A61K39/13 ,  A61K39/145 ,  A61K39/29 ,  A61K39/00

Abstract: Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.

公开(公告)号：US20170224616A1

公开(公告)日：2017-08-10

申请号：US15495066

申请日：2017-04-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Luis Brito ,  Michelle Chan ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

IPC: A61K9/107 ,  A61K39/12

CPC classification number: A61K9/107 ,  A61K9/0019 ,  A61K31/713 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/53 ,  A61K2039/55566 ,  C12N2760/18534 ,  Y02A50/412 ,  Y02A50/489

Abstract: This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.

公开(公告)号：US20170202960A1

公开(公告)日：2017-07-20

申请号：US15467660

申请日：2017-03-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Luis Brito ,  Michelle Chan ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

IPC: A61K39/39 ,  A61K47/02 ,  A61K47/12 ,  C12N7/00 ,  A61K47/34 ,  A61K47/22 ,  A61K39/245 ,  A61K39/155 ,  A61K47/06 ,  A61K47/26

CPC classification number: A61K39/39 ,  A61K9/1075 ,  A61K39/12 ,  A61K39/155 ,  A61K39/245 ,  A61K47/02 ,  A61K47/06 ,  A61K47/12 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  C12N7/00 ,  C12N2710/16134 ,  C12N2710/16171 ,  C12N2710/16734 ,  C12N2710/16771 ,  C12N2760/18534 ,  C12N2760/18571 ,  C12N2770/36134 ,  C12N2770/36143 ,  C12N2840/203 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/412

Abstract: This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.

公开(公告)号：US10603369B2

公开(公告)日：2020-03-31

申请号：US15887203

申请日：2018-02-02

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Barbara Baudner ,  David Skibinski ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/00 ,  A61K31/4375 ,  A61K31/66 ,  A61K33/06 ,  A61K39/39 ,  A61K39/12 ,  A61K39/102 ,  A61K39/116 ,  A61K39/295

Abstract: Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.

公开(公告)号：US10238733B2

公开(公告)日：2019-03-26

申请号：US15067216

申请日：2016-03-11

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Luis Brito ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

IPC: A61K39/395 ,  A61K39/385 ,  A61K9/107 ,  A61K39/39 ,  A61K39/00

Abstract: This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.

公开(公告)号：US20160375132A1

公开(公告)日：2016-12-29

申请号：US15201651

申请日：2016-07-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： David Skibinski ,  Siddhartha Jain ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/39 ,  A61K39/12 ,  A61K31/4745 ,  A61K39/095 ,  A61K39/155

CPC classification number: A61K39/39 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/683 ,  A61K31/7004 ,  A61K31/717 ,  A61K39/095 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  C12N2760/14134 ,  C12N2760/18534 ,  Y02A50/41 ,  A61K2300/00

Abstract: The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.

公开(公告)号：US10183074B2

公开(公告)日：2019-01-22

申请号：US15467660

申请日：2017-03-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Luis Brito ,  Michelle Chan ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

IPC: A61K9/107 ,  A61K39/00 ,  A61K39/12 ,  A61K47/12 ,  A61K39/39 ,  A61K47/06 ,  A61K47/24 ,  A61K39/155 ,  A61K39/245 ,  A61K47/02 ,  A61K47/22 ,  A61K47/26 ,  A61K47/34 ,  C12N7/00

Abstract: This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.

公开(公告)号：US10046048B2

公开(公告)日：2018-08-14

申请号：US15201651

申请日：2016-07-05

Applicant: GlaxoSmithKline Biologicals SA

Inventor： David Skibinksi ,  Siddhartha Jain ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/39 ,  A61K31/4745 ,  A61K31/7004 ,  A61K31/717 ,  A61K39/095 ,  A61K39/155 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/683 ,  A61K39/12 ,  A61K39/00

Abstract: The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.

公开(公告)号：US09795668B2

公开(公告)日：2017-10-24

申请号：US14948908

申请日：2015-11-23

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Siddhartha Jain ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/385 ,  C12Q1/68 ,  A61K9/16 ,  A61K9/51 ,  A61K39/155 ,  C12N15/86 ,  C12N15/88 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/385 ,  A61K9/1617 ,  A61K9/1647 ,  A61K9/5123 ,  A61K9/5153 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/622 ,  A61P31/14 ,  C12N15/86 ,  C12N15/88 ,  C12N2760/18534 ,  C12N2770/36143

Abstract: Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described.