公开(公告)号：US20220305112A1

公开(公告)日：2022-09-29

申请号：US17680433

申请日：2022-02-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Robbert Gerrit VAN DER MOST

IPC: A61K39/215 ,  A61K39/39

Abstract: The present invention relates to immunisation with a coronavirus spike antigen and a squalene emulsion adjuvant to elicit broad immune responses, and to related aspects.

公开(公告)号：US20170136110A1

公开(公告)日：2017-05-18

申请号：US15300338

申请日：2015-04-02

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： William Ripley BALLOU, JR. ,  Arnaud Michel DIDIERLAURENT ,  Robbert Gerrit VAN DER MOST

IPC: A61K39/015 ,  A61K39/29

Abstract: Methods and uses are provided for inducing an immune response comprising at least two administrations of an immunogenic composition, wherein a lower dose is given in the second administration than in the first administration, and wherein the second administration may be unadjuvanted.

公开(公告)号：US20200306353A1

公开(公告)日：2020-10-01

申请号：US16815635

申请日：2020-03-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： William Ripley BALLOU, JR. ,  Arnaud Michel DIDIERLAURENT ,  Robbert Gerrit VAN DER MOST

IPC: A61K39/015 ,  A61K39/04 ,  A61K39/29

Abstract: Methods of inducing an immune response comprising at least two administrations of an adjuvanted immunogenic composition, wherein the second administration contains reduced amounts of antigen and adjuvant.