公开(公告)号：US20240110926A1

公开(公告)日：2024-04-04

申请号：US18257412

申请日：2021-12-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Sonia BUDRONI ,  Simona RONDINI ,  Silvia ROSSI PACCANI

IPC: G01N33/68 ,  A61K45/00

CPC classification number: G01N33/6869 ,  A61K45/00 ,  G01N2333/525 ,  G01N2333/545 ,  G01N2800/122 ,  G01N2800/26 ,  G01N2800/52

Abstract: The present invention relates to antibiotic agents for use in the treatment of patients presenting with an exacerbation of chronic obstructive pulmonary disease (COPD). More particularly the present invention relates to antibiotic agents for use in the treatment of COPD exacerbations in patients that, through analysis, have been identified as having an increased concentration of the IL-1α and TNF-α cytokine biomarkers in a biological sample taken from said patient. The present invention is further directed to methods of diagnosing and methods of treating a patient presenting with an exacerbation of COPD, said methods including identifying 1 the patient is suffering from an exacerbation that is associated with a bacterial infection.