公开(公告)号：US20160368911A1

公开(公告)日：2016-12-22

申请号：US14898782

申请日：2014-07-01

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Sebastien Andre CAMPOS ,  John David HARLING ,  Afjal Hussain MIAH ,  Ian Edward, David SMITH

IPC: C07D417/14 ,  C07D413/14 ,  A61K31/422 ,  A61K45/06 ,  C07D471/10 ,  A61K31/435 ,  C07K5/062 ,  A61K38/05 ,  A61K31/427 ,  A61K31/496

CPC classification number: C07D417/14 ,  A61K31/422 ,  A61K31/427 ,  A61K31/435 ,  A61K31/496 ,  A61K38/05 ,  A61K45/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D471/10 ,  C07K5/06052

Abstract: A compound of formula (I): or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor,

Abstract translation: 或其药学上可接受的盐，含有所述化合物的组合物，组合和药物及其制备方法。 本发明还涉及所述化合物，组合，组合物和药物的用途，例如作为雌激素受体活性的抑制剂，包括降解雌激素受体，治疗由雌激素受体介导的疾病和病症，