公开(公告)号：US20250057958A1

公开(公告)日：2025-02-20

申请号：US18802386

申请日：2024-08-13

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Peiling Chen ,  Michael Gerard Darcy ,  Jason W. Dodson ,  Beth Anne Knapp-Reed ,  Joseph Paul Marino, JR. ,  Jeffrey Alan Oplinger ,  Matthew Robert Sender ,  Brandon James Turunen ,  Guosen Ye ,  Cunyu Zhang

IPC: A61K47/54

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.