公开(公告)号：US11970480B2

公开(公告)日：2024-04-30

申请号：US17663749

申请日：2022-05-17

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

发明人： Adam Kenneth Charnley ,  Michael G. Darcy ,  Jason W. Dodson ,  Xiaoyang Dong ,  Terry V. Hughes ,  Jianxing Kang ,  Lara Kathryn Leister ,  Yiqian Lian ,  Yue Li ,  John F. Mehlmann ,  Neysa Nevins ,  Joshi M. Ramanjulu ,  Joseph J. Romano ,  Gren Z. Wang ,  Guosen Ye ,  Daohua Zhang

IPC分类号： C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/6558

CPC分类号： C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/65583

摘要： Disclosed are compounds having the formula:






wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US10975287B2

公开(公告)日：2021-04-13

申请号：US16091945

申请日：2017-04-05

申请人： GlaxoSmithKline Intellectual Property Development Limited

发明人： Adam Kenneth Charnley ,  Michael G. Darcy ,  Jason W. Dodson ,  Terry V. Hughes ,  Yue Li ,  Yiqian Lian ,  Neysa Nevins ,  Joshi M. Ramanjulu

IPC分类号： C07D401/14 ,  C07D403/12 ,  A61P31/18 ,  C09K8/508 ,  C09K8/512 ,  C09K8/516 ,  E21B33/13 ,  E21B47/10 ,  C07D403/14 ,  C07D413/14

摘要： Disclosed are compounds having the formula: wherein Ra, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein, or a salt, particularly a pharmaceutically acceptable salt, thereof.