公开(公告)号：US20250057958A1

公开(公告)日：2025-02-20

申请号：US18802386

申请日：2024-08-13

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Peiling Chen ,  Michael Gerard Darcy ,  Jason W. Dodson ,  Beth Anne Knapp-Reed ,  Joseph Paul Marino, JR. ,  Jeffrey Alan Oplinger ,  Matthew Robert Sender ,  Brandon James Turunen ,  Guosen Ye ,  Cunyu Zhang

IPC: A61K47/54

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

公开(公告)号：US11976057B2

公开(公告)日：2024-05-07

申请号：US17492978

申请日：2021-10-04

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Edward Brnardic ,  Michael Bury ,  Rodolfo Cadilla ,  Jon Collins ,  Yu Guo ,  Anthony Handlon ,  Huijie Li ,  Yue Li ,  Daniel Paone ,  Christie Schulte ,  Barry Shearer ,  Maben Ying ,  Guosen Ye ,  Huichang Zhang ,  Millard Hurst Lambert, III

IPC: C07D401/14 ,  A61P17/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D401/14 ,  A61P17/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.

公开(公告)号：US11970480B2

公开(公告)日：2024-04-30

申请号：US17663749

申请日：2022-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth Charnley ,  Michael G. Darcy ,  Jason W. Dodson ,  Xiaoyang Dong ,  Terry V. Hughes ,  Jianxing Kang ,  Lara Kathryn Leister ,  Yiqian Lian ,  Yue Li ,  John F. Mehlmann ,  Neysa Nevins ,  Joshi M. Ramanjulu ,  Joseph J. Romano ,  Gren Z. Wang ,  Guosen Ye ,  Daohua Zhang

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/6558

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/65583

Abstract: Disclosed are compounds having the formula:






wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.