公开(公告)号：US10688193B2

公开(公告)日：2020-06-23

申请号：US15746544

申请日：2016-07-21

申请人： GNT BIOTECH & MEDICALS CORPORATION

发明人： Yu-Jung Liao ,  Wei-Jan Huang ,  Chia-Nan Chen ,  Huan-Yu Lin ,  Ching-Yi Lin ,  Meng-Ju Tsai ,  Wan-Yi Hsu ,  Li-Ling Chi ,  Ye-Su Chao ,  Yi-Hong Wu

IPC分类号： A61K47/64 ,  A61K47/60 ,  A61K47/69 ,  C07C243/26 ,  C07C271/22 ,  C07C323/60 ,  C07K5/062 ,  A61K9/14 ,  C07C323/52 ,  C07D339/04 ,  C07K5/103 ,  A61P35/00 ,  A61K47/20 ,  A61K31/351 ,  A61K31/437 ,  A61K33/24 ,  A61K47/22

摘要： The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.