公开(公告)号：US09855263B2

公开(公告)日：2018-01-02

申请号：US15169778

申请日：2016-06-01

申请人： GRÜNENTHAL GMBH

发明人： Klaus Wening ,  Anja Geiβler ,  Jana Denker ,  Lutz Barnscheid

IPC分类号： A61K9/50 ,  A61K31/485 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K31/137

CPC分类号： A61K31/485 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K9/2077 ,  A61K9/4808 ,  A61K9/50 ,  A61K31/137

摘要： A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.

公开(公告)号：US10695297B2

公开(公告)日：2020-06-30

申请号：US16416532

申请日：2019-05-20

申请人： Grünenthal GmbH

发明人： Sebastian Schwier ,  Marcel Haupts ,  Udo Rüttgers ,  Lutz Barnscheid ,  Jana Denker

IPC分类号： A61K9/20 ,  A61K31/135 ,  A61K9/28 ,  A61K31/137 ,  A61K31/138 ,  A61K31/485

摘要： The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a polyalkylene oxide; and form a discontinuous phase within the matrix material; and method of using said tablet to treat pain and other conditions.

公开(公告)号：US20190054081A1

公开(公告)日：2019-02-21

申请号：US16167208

申请日：2018-10-22

申请人： GRÜNENTHAL GMBH

发明人： Klaus Wening ,  Anja Geissler-Fichtner ,  Jana Denker ,  Lutz Barnscheid

IPC分类号： A61K31/485 ,  A61K9/48 ,  A61K9/16 ,  A61K9/20 ,  A61K9/50 ,  A61K31/137

摘要： A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.