公开(公告)号：US10829480B2

公开(公告)日：2020-11-10

申请号：US16265080

申请日：2019-02-01

Applicant: GRUENENTHAL GMBH

Inventor： Sven Kuehnert ,  Rene Michael Koenigs ,  Achim Kless ,  Anita Wegert ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder ,  Klaus Schiene ,  Ingo Konetzki

IPC: C07D405/06 ,  C07D235/02 ,  C07D401/06 ,  C07D403/06

Abstract: The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20190106429A1

公开(公告)日：2019-04-11

申请号：US16207854

申请日：2018-12-03

Applicant: GRUENENTHAL GMBH

Inventor： Sven Kuehnert ,  Rene Koenigs ,  Achim Kless ,  Anita Wegert ,  Ingo Konetzki ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D487/04 ,  C07D409/04 ,  C07D401/02 ,  C07D405/02 ,  C07D471/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/04 ,  C07D413/14 ,  C07D403/14 ,  C07D405/06 ,  C07D409/14 ,  C07D401/04 ,  C07D235/02 ,  C07D403/04 ,  C07D413/02

Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20180201616A1

公开(公告)日：2018-07-19

申请号：US15923948

申请日：2018-03-16

Applicant: Gruenenthal GmbH

Inventor： Sven Kuehnert ,  Rene Koenigs ,  Achim Kless ,  Anita Wegert ,  Ingo Konetzki ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D487/04 ,  C07D471/04 ,  C07D235/02 ,  C07D413/14 ,  C07D413/02 ,  C07D409/14 ,  C07D409/04 ,  C07D405/14 ,  C07D405/06 ,  C07D405/02 ,  C07D403/14 ,  C07D403/04 ,  C07D401/14 ,  C07D401/04 ,  C07D401/02 ,  C07D417/04

CPC classification number: C07D487/04 ,  C07D235/02 ,  C07D401/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/02 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/02 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04

Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3 -diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US11999699B2

公开(公告)日：2024-06-04

申请号：US17840712

申请日：2022-06-15

Applicant: GRUENENTHAL GMBH

Inventor： Sebastian Krueger ,  Sebastian Peil ,  Clemens Dialer ,  Marcel Muelbaier ,  Markus Wagener ,  Ingo Konetzki ,  Nikolay Sitnikov ,  Jo Alen ,  Martin Pettersson

IPC: C07D231/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/14 ,  C07D413/12

CPC classification number: C07D231/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/14 ,  C07D413/12

Abstract: The present invention relates to compounds according to general formula (I)




which act as inhibitors of NaV1.8 and can be used in the treatment of pain.