公开(公告)号：US20230183184A1

公开(公告)日：2023-06-15

申请号：US18102983

申请日：2023-01-30

Applicant: Gruenenthal GmbH

Inventor： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Florian JAKOB ,  Achim KLESS ,  Anita WEGERT ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER

IPC: C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

CPC classification number: C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

Abstract: The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20220372041A1

公开(公告)日：2022-11-24

申请号：US17866672

申请日：2022-07-18

Applicant: GRUENENTHAL GMBH

Inventor： Jo ALEN ,  Florian JAKOB ,  Sebastian KRUEGER ,  Philipp BARBIE ,  Daniela FRIEBE ,  Stephanie HENNEN

IPC: C07D487/04 ,  C07D498/04 ,  C07D471/04 ,  C07D471/14 ,  A61P29/00

Abstract: The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US11311504B2

公开(公告)日：2022-04-26

申请号：US16502651

申请日：2019-07-03

Applicant: Gruenenthal GmbH

Inventor： Stefanie Frosch ,  Klaus Linz ,  Klaus Schiene

IPC: A61K31/167 ,  A61K31/407 ,  A61K31/223

Abstract: The invention relates to a pharmaceutical composition comprising a first pharmacologically active ingredient selected from (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and the physiologically acceptable salts thereof, and a second pharmacologically active ingredient selected from paracetamol and propacetamol.

公开(公告)号：US10829480B2

公开(公告)日：2020-11-10

申请号：US16265080

申请日：2019-02-01

Applicant: GRUENENTHAL GMBH

Inventor： Sven Kuehnert ,  Rene Michael Koenigs ,  Achim Kless ,  Anita Wegert ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder ,  Klaus Schiene ,  Ingo Konetzki

IPC: C07D405/06 ,  C07D235/02 ,  C07D401/06 ,  C07D403/06

Abstract: The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20200223840A1

公开(公告)日：2020-07-16

申请号：US16740735

申请日：2020-01-13

Applicant: Gruenenthal GMBH

Inventor： Florian JAKOB ,  Jo ALEN ,  Sebastian KRÜGER ,  Daniela FRIEBE ,  Stephanie HENNEN ,  Philipp BARBIE

IPC: C07D417/14 ,  C07D403/10 ,  C07D471/04 ,  C07D409/14 ,  C07D403/14 ,  C07D413/14 ,  C07D401/14

Abstract: The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

公开(公告)号：US20190117634A1

公开(公告)日：2019-04-25

申请号：US16156775

申请日：2018-10-10

Applicant: Gruenenthal GmbH

Inventor： Emilio QUETGLAS ,  Peter HEIN ,  Wolfgang SCHRÖDER ,  Andreas SCHOLZ

IPC: A61K31/438 ,  A61K9/00 ,  A61P15/02

Abstract: The invention relates to a pharmaceutical composition comprising cis-(E)-4-(3-fluorophenyl)-2′,3′,4′,9′-tetrahydro-N,N-dimethyl-2′-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1′[1H]-pyrido[3,4-b]indol]-4-amine. The pharmaceutical composition is suitable for local treatment of vulvar pain such as vulvodynia.

公开(公告)号：US20190106429A1

公开(公告)日：2019-04-11

申请号：US16207854

申请日：2018-12-03

Applicant: GRUENENTHAL GMBH

Inventor： Sven Kuehnert ,  Rene Koenigs ,  Achim Kless ,  Anita Wegert ,  Ingo Konetzki ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D487/04 ,  C07D409/04 ,  C07D401/02 ,  C07D405/02 ,  C07D471/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/04 ,  C07D413/14 ,  C07D403/14 ,  C07D405/06 ,  C07D409/14 ,  C07D401/04 ,  C07D235/02 ,  C07D403/04 ,  C07D413/02

Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US10202345B2

公开(公告)日：2019-02-12

申请号：US14799872

申请日：2015-07-15

Applicant: Gruenenthal GmbH

Inventor： Anita Wegert ,  Bert Nolte ,  Klaus Linz ,  Stephanie Harlfinger ,  Babette-Yvonne Koegel ,  Paul Ratcliffe ,  Fritz Theil ,  Olga Groeger ,  Birgit Braun

IPC: C07D209/54 ,  C07D405/06 ,  C07D409/04 ,  C07D409/14 ,  C07D209/96

Abstract: The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

公开(公告)号：US20180273491A1

公开(公告)日：2018-09-27

申请号：US15979932

申请日：2018-05-15

Applicant: GRUENENTHAL GMBH

Inventor： Sven KUEHNERT ,  Rene Michael KOENIGS ,  Florian JAKOB ,  Achim KLESS ,  Anita WEGERT ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER

IPC: C07D235/02 ,  C07D405/12 ,  C07D487/04 ,  C07D401/06 ,  C07D403/12 ,  C07D413/12 ,  C07D403/06 ,  C07D401/12 ,  C07D417/06

CPC classification number: C07D235/02 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

Abstract: The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US20180201616A1

公开(公告)日：2018-07-19

申请号：US15923948

申请日：2018-03-16

Applicant: Gruenenthal GmbH

Inventor： Sven Kuehnert ,  Rene Koenigs ,  Achim Kless ,  Anita Wegert ,  Ingo Konetzki ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D487/04 ,  C07D471/04 ,  C07D235/02 ,  C07D413/14 ,  C07D413/02 ,  C07D409/14 ,  C07D409/04 ,  C07D405/14 ,  C07D405/06 ,  C07D405/02 ,  C07D403/14 ,  C07D403/04 ,  C07D401/14 ,  C07D401/04 ,  C07D401/02 ,  C07D417/04

CPC classification number: C07D487/04 ,  C07D235/02 ,  C07D401/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/02 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/02 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04

Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3 -diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.