公开(公告)号：US11413335B2

公开(公告)日：2022-08-16

申请号：US15895468

申请日：2018-02-13

申请人： GUANGZHOU BIOSEAL BIOTECH CO. LTD. ,  Ethicon, Inc.

发明人： Shuang Chen ,  Yufu Li ,  Aibin Yu ,  Jianping Yu

IPC分类号： A61K38/36 ,  A61K38/48 ,  A61K31/717 ,  A61K9/16 ,  A61P11/00 ,  A61K9/00 ,  A61K9/06 ,  A61L24/10 ,  A61L24/08

摘要： The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent, agitating and shearing said suspension in a high shear mixing reactor, adding water to allow particles to agglomerate, allowing the non-aqueous solvent to evaporate, drying and sieving the composition; and thus forming the powdered hemostatic composition.

公开(公告)号：US20220111020A1

公开(公告)日：2022-04-14

申请号：US17560432

申请日：2021-12-23

申请人： GUANGZHOU BIOSEAL BIOTECH CO. LTD. ,  Ethicon, Inc.

发明人： Shuang Chen ,  Yufu Li ,  Aibin Yu ,  Jianping Yu

IPC分类号： A61K38/48 ,  A61K38/36 ,  A61K31/717 ,  A61K9/16 ,  A61P11/00 ,  A61K9/00 ,  A61K9/06 ,  A61L24/10 ,  A61L24/08

摘要： The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent, agitating and shearing said suspension in a high shear mixing reactor, adding water to allow particles to agglomerate, allowing the non-aqueous solvent to evaporate, drying and sieving the composition; and thus forming the powdered hemostatic composition.

公开(公告)号：US20190247474A1

公开(公告)日：2019-08-15

申请号：US15895468

申请日：2018-02-13

申请人： GUANGZHOU BIOSEAL BIOTECH CO. LTD. ,  Ethicon, Inc.

发明人： Shuang Chen ,  Yufu Li ,  Aibin Yu ,  Jianping Yu

IPC分类号： A61K38/48 ,  A61K38/36 ,  A61K31/717 ,  A61K9/16 ,  A61K9/00 ,  A61K9/06 ,  A61P11/00

CPC分类号： A61K38/4833 ,  A61K9/007 ,  A61K9/06 ,  A61K9/16 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1682 ,  A61K31/717 ,  A61K38/363 ,  A61L24/08 ,  A61L24/106 ,  A61L24/108 ,  A61L2400/04 ,  A61P11/00 ,  C08L1/04

摘要： The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent, agitating and shearing said suspension in a high shear mixing reactor, adding water to allow particles to agglomerate, allowing the non-aqueous solvent to evaporate, drying and sieving the composition; and thus forming the powdered hemostatic composition.