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公开(公告)号：US20230391744A1
公开(公告)日：2023-12-07
申请号：US18033621
申请日：2021-10-26
发明人： Deyao LI , Yiqian ZHOU , Qi GUO , Huajin YOU , Lijun ZHANG , Jiancun ZHANG
IPC分类号： C07D333/26
CPC分类号： C07D333/26
摘要： A novel tetrahydronaphthalene compound is provided, or a stereoisomer, a solvate, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition including the compound, and a use of the compound or the composition for preparing a medicament in prevention and/or treatment of a central nervous system disease, wherein the compound has a structure of formula (I),
wherein each of X, Y, Z, W and R is defined as described in the present disclosure.-
公开(公告)号：US20230340009A1
公开(公告)日：2023-10-26
申请号：US18217783
申请日：2023-07-03
发明人： Jiancun ZHANG , Lijun ZHANG , Yiqian ZHOU , Jiafeng CHEN , Jufu ZHANG , Suyong LI , Yanhui LIU , Chen GUO , Wanjun TANG , Feng WU , Xiaoxi HE , Qi GUO , Huixuan CHEN , Kun WANG , Deyao Li
摘要： The present disclosure relates to compounds for RNA capping and uses thereof, which belong to the technical field of genetic engineering. Compounds of formula I can result in high levels of capping efficiency, and the capped mRNA exhibits a high transcription level and increased expression.
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