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8 条记录 (耗时 0.016 秒)

    Long-acting prodrugs of rasagiline, preparing methods and uses thereof
    2.
    发明授权
    Long-acting prodrugs of rasagiline, preparing methods and uses thereof 有权

    公开(公告)号：US11369583B2

    公开(公告)日：2022-06-28

    申请号：US16641802

    申请日：2018-08-27

    申请人： GUANGZHOU HENOVCOM BIOSCIENCE CO. LTD

    发明人： Jiancun Zhang ,  Deyao Li ,  Yiqian Zhou ,  Yiwu Wu

    IPC分类号： A61K31/27 ,  A61K31/4188 ,  A61K31/575

    摘要： Provided are a long-acting prodrug of Rasagiline, which has application in the treatment of Central Nervous System diseases such as Parkinson's disease, preparation method and use thereof. The long-acting prodrug of Rasagiline has a structure of formula (I), wherein T is absent, or T is selected from each of R1 and R2 is independently selected from H, D, and alkyl; W is absent, or W is selected from (CH2)n, wherein n is an integer selected from 1 to 15; X is absent, or X is selected from (CH2)m, wherein m is an integer selected from 1 to 10; Y is absent, or Y is selected from —C(═O)NH—, —NHC(═O)—; R3 is selected from substituted or unsubstituted C1-C30 alkyl, substituted or unsubstituted C2-C30 alkenyl, substituted or unsubstituted C2-C30 alkynyl, substituted or unsubstituted C3-C30 cycloalkyl, cholane aliphatic group, —R3a—C(═O)O—R3b, —R3a—OC(═O)—R3b, —R3a—C(═O)NH—R3b, —R3a—NHC(═O)—R3b, —R3a—S(═O)1-2O—R3b and —R3a—OS(═O)1-2—R3b.

    Cyclohexene compounds and use thereof
    3.
    发明授权
    Cyclohexene compounds and use thereof 有权

    公开(公告)号：US10919856B2

    公开(公告)日：2021-02-16

    申请号：US16331797

    申请日：2017-09-05

    申请人： GUANGZHOU HENOVCOM BIOSCIENCE CO. LTD

    发明人： Jiancun Zhang ,  Kun Wang ,  Yan Liu ,  Deyao Li

    IPC分类号： C07D211/42 ,  A61K31/451 ,  A61P31/16 ,  C07D211/22 ,  A61P11/00 ,  C07D211/32

    摘要： A cyclohexene compound and use thereof, which relates to the technical field of pharmaceutical chemistry is provided. The cyclohexene compound is the cyclohexene compound having a structural formula I or a pharmaceutically acceptable salt, an ester group prodrug or a stereoisomer thereof. It is verified by activity assay for influenza NA that the cyclohexene compound has a great inhibiting activity against both wild-typed and drug-resistant influenza viruses, and the inhibiting activity IC50 of some compounds against wild-typed and drug-resistant influenza viruses is lower than 5 nM, showing significant inhibiting effect on influenza viruses. This shows that the cyclohexene compound or a pharmaceutically acceptable salt or a stereoisomer thereof has superior application prospect on preparing anti-influenza drugs, thereby providing a new drug choice for treating influenza clinically.

    CYCLOHEXENE COMPOUNDS AND USE THEREOF
    8.
    发明申请
    CYCLOHEXENE COMPOUNDS AND USE THEREOF 审中-公开

    公开(公告)号：US20190241520A1

    公开(公告)日：2019-08-08

    申请号：US16331797

    申请日：2017-09-05

    申请人： GUANGZHOU HENOVCOM BIOSCIENCE CO. LTD

    发明人： Jiancun Zhang ,  Kun Wang ,  Yan Liu ,  Deyao Li

    IPC分类号： C07D211/42 ,  C07D211/32

    CPC分类号： C07D211/42 ,  A61K31/451 ,  A61P11/00 ,  A61P31/16 ,  C07D211/22 ,  C07D211/32

    摘要： A cyclohexene compound and use thereof, which relates to the technical field of pharmaceutical chemistry is provided. The cyclohexene compound is the cyclohexene compound having a structural formula I or a pharmaceutically acceptable salt, an ester group prodrug or a stereoisomer thereof. It is verified by activity assay for influenza NA that the cyclohexene compound has a great inhibiting activity against both wild-typed and drug-resistant influenza viruses, and the inhibiting activity IC50 of some compounds against wild-typed and drug-resistant influenza viruses is lower than 5 nM, showing significant inhibiting effect on influenza viruses. This shows that the cyclohexene compound or a pharmaceutically acceptable salt or a stereoisomer thereof has superior application prospect on preparing anti-influenza drugs, thereby providing a new drug choice for treating influenza clinically.