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    Transdermal Delivery System for Polynucleotides
    3.
    发明申请
    Transdermal Delivery System for Polynucleotides 有权
    多核苷酸的透皮递送系统

    公开(公告)号：US20080114281A1

    公开(公告)日：2008-05-15

    申请号：US10597431

    申请日：2005-01-25

    申请人： James Birchall ,  Galit Levin ,  Amikam Gershonowitz

    发明人： James Birchall ,  Galit Levin ,  Amikam Gershonowitz

    IPC分类号： A61K31/70 ,  A61P43/00 ,  A61N1/30

    CPC分类号： A61N1/327

    摘要： The present invention relates to a system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and to methods of use thereof. Particularly, the present invention relates to a system comprising an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods of the present invention achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.

    摘要翻译： 本发明涉及用于寡核苷酸或多核苷酸的皮内或透皮递送的系统及其使用方法。 特别地，本发明涉及一种系统，其包括与包含寡核苷酸或多核苷酸的药物组合物结合的受试者皮肤中产生微通道的装置，其中所述寡核苷酸或多核苷酸可以通过微量载体递送至生物体， 频道 本发明的系统和方法实现由多核苷酸编码的靶蛋白的表达，因此可用于免疫和基因治疗。

    Transdermal delivery system for polynucleotides
    4.
    发明授权
    Transdermal delivery system for polynucleotides 有权
    多核苷酸的透皮递送系统

    公开(公告)号：US08041421B2

    公开(公告)日：2011-10-18

    申请号：US10597431

    申请日：2005-01-25

    申请人： James Birchall ,  Galit Levin ,  Amikam Gershonowitz

    发明人： James Birchall ,  Galit Levin ,  Amikam Gershonowitz

    IPC分类号： A61N1/30 ,  A61M31/00

    CPC分类号： A61N1/327

    摘要： A system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and methods of use thereof employ an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.

    摘要翻译： 寡核苷酸或多核苷酸的皮内或透皮递送系统及其使用方法采用与包含寡核苷酸或多核苷酸的药物组合物结合的受试者皮肤中产生微通道的装置，其中所述寡核苷酸或多核苷酸可被递送 通过微通道进入生物体。 该系统和方法实现由多核苷酸编码的靶蛋白的表达，因此可用于免疫和基因治疗。