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1.发明申请POLYPEPTIDES AND USES THEREOF AS A DRUG FOR TREATMENT OF MULTIPLE SCLEROSIS, RHEUMATOID ARTHRITIS AND OTHER AUTOIMMUNE DISORDERS 审中-公开多肽及其作为治疗多发性硬化症，恶病质和其他自身免疫性疾病的药物的用途公开(公告)号：US20130209463A1
公开(公告)日：2013-08-15
申请号：US13806841
申请日：2011-06-30
申请人： Galit Rotman , Iris Hecht , Zurit Levine , Joseph R. Podojil , Stephen D. Miller
发明人： Galit Rotman , Iris Hecht , Zurit Levine , Joseph R. Podojil , Stephen D. Miller
IPC分类号： C07K14/47
CPC分类号： A61K38/1709 , C07K14/4713 , Y02A50/40 , Y02A50/401
摘要： This invention relates to a protein C1ORF32 and its variants and fragments and fusion proteins thereof, and methods of use thereof for immunotherapy, and drug development, including but not limited to as immune modulators and for immune therapy, including for autoimmune disorders.
摘要翻译： 本发明涉及蛋白质C1ORF32及其变体及其片段和融合蛋白，以及其用于免疫治疗和药物开发的方法，包括但不限于免疫调节剂和免疫治疗，包括用于自身免疫疾病。
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公开(公告)号：US20120276095A1
公开(公告)日：2012-11-01
申请号：US13392811
申请日：2010-08-31
IPC分类号： A61K39/395 , A61P29/00 , C07K19/00
CPC分类号： C07K14/70532 , A61K9/0019 , A61K38/00 , A61K38/1709 , A61K39/44 , C07K16/2827 , C07K2317/50 , C07K2317/56 , C07K2317/72 , C07K2319/30 , C07K2319/32 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N2800/52
摘要： Fusion proteins containing B7-H4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by ThI, ThI 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1β, TNF-α, TGF-beta, IFN-γ, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof.
摘要翻译： 公开了含有B7-H4多肽的融合蛋白。 B7-H4融合蛋白可以包括全长B7-H4多肽，或者可以含有全长B7-H4多肽的片段，包括B7-H4多肽的一些或全部细胞外结构域。 还公开了使用融合蛋白来下调T细胞活化和治疗炎性和自身免疫性疾病和病症的方法。 B7-H4融合蛋白可用于通过抑制或减少Th1，Th17，Th22和/或分泌或引起其他细胞的其他细胞的分化，增殖，活性和/或细胞因子产生和/或分泌来治疗炎症 包括但不限于IL-1和bgr; TNF-α，TGF-β，IFN-γ，IL-17，IL-6，IL-23，IL-22，IL-21， 和MMPs; 或增强Treg的IL-10分泌，增加Treg的分化，增加Treg的数量或其组合。
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公开(公告)号：US09011853B2
公开(公告)日：2015-04-21
申请号：US13392811
申请日：2010-08-31
CPC分类号： C07K14/70532 , A61K9/0019 , A61K38/00 , A61K38/1709 , A61K39/44 , C07K16/2827 , C07K2317/50 , C07K2317/56 , C07K2317/72 , C07K2319/30 , C07K2319/32 , G01N33/6863 , G01N33/6866 , G01N33/6869 , G01N2800/52
摘要： Fusion proteins containing B7-H4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by ThI, ThI 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1β, TNF-α, TGF-beta, IFN-γ, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof.
摘要翻译： 公开了含有B7-H4多肽的融合蛋白。 B7-H4融合蛋白可以包括全长B7-H4多肽，或可以含有全长B7-H4多肽的片段，包括B7-H4多肽的一些或全部细胞外结构域。 还公开了使用融合蛋白来下调T细胞活化和治疗炎性和自身免疫性疾病和病症的方法。 B7-H4融合蛋白可用于通过抑制或减少Th1，Th17，Th22和/或分泌或引起其他细胞的其他细胞的分化，增殖，活性和/或细胞因子产生和/或分泌来治疗炎症 包括但不限于IL-1和bgr; TNF-α，TGF-β，IFN-γ，IL-17，IL-6，IL-23，IL-22，IL-21， 和MMPs; 或增强Treg的IL-10分泌，增加Treg的分化，增加Treg的数量或其组合。
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