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    B7-H4 FUSION PROTEINS AND METHODS OF USE THEREOF
    2.
    发明申请
    B7-H4 FUSION PROTEINS AND METHODS OF USE THEREOF 有权
    B7-H4融合蛋白及其使用方法

    公开(公告)号：US20120276095A1

    公开(公告)日：2012-11-01

    申请号：US13392811

    申请日：2010-08-31

    申请人： Solomon Langermann ,  Linda Liu ,  Joseph R. Podojil ,  Stephen D. Miller ,  Shannon Marshall

    发明人： Solomon Langermann ,  Linda Liu ,  Joseph R. Podojil ,  Stephen D. Miller ,  Shannon Marshall

    IPC分类号： A61K39/395 ,  A61P29/00 ,  C07K19/00

    CPC分类号： C07K14/70532 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/1709 ,  A61K39/44 ,  C07K16/2827 ,  C07K2317/50 ,  C07K2317/56 ,  C07K2317/72 ,  C07K2319/30 ,  C07K2319/32 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N2800/52

    摘要： Fusion proteins containing B7-H4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by ThI, ThI 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1β, TNF-α, TGF-beta, IFN-γ, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof.

    摘要翻译： 公开了含有B7-H4多肽的融合蛋白。 B7-H4融合蛋白可以包括全长B7-H4多肽，或者可以含有全长B7-H4多肽的片段，包括B7-H4多肽的一些或全部细胞外结构域。 还公开了使用融合蛋白来下调T细胞活化和治疗炎性和自身免疫性疾病和病症的方法。 B7-H4融合蛋白可用于通过抑制或减少Th1，Th17，Th22和/或分泌或引起其他细胞的其他细胞的分化，增殖，活性和/或细胞因子产生和/或分泌来治疗炎症 包括但不限于IL-1和bgr; TNF-α，TGF-β，IFN-γ，IL-17，IL-6，IL-23，IL-22，IL-21， 和MMPs; 或增强Treg的IL-10分泌，增加Treg的分化，增加Treg的数量或其组合。

    B7-H4 fusion proteins and methods of use thereof
    3.
    发明授权
    B7-H4 fusion proteins and methods of use thereof 有权
    B7-H4融合蛋白及其使用方法

    公开(公告)号：US09011853B2

    公开(公告)日：2015-04-21

    申请号：US13392811

    申请日：2010-08-31

    申请人： Solomon Langermann ,  Linda Liu ,  Joseph R. Podojil ,  Stephen D. Miller ,  Shannon Marshall

    发明人： Solomon Langermann ,  Linda Liu ,  Joseph R. Podojil ,  Stephen D. Miller ,  Shannon Marshall

    IPC分类号： A61K38/16 ,  C07K14/705 ,  C07K16/46 ,  G01N33/68 ,  A61K38/17 ,  C07K16/28

    CPC分类号： C07K14/70532 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/1709 ,  A61K39/44 ,  C07K16/2827 ,  C07K2317/50 ,  C07K2317/56 ,  C07K2317/72 ,  C07K2319/30 ,  C07K2319/32 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N2800/52

    摘要： Fusion proteins containing B7-H4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by ThI, ThI 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1β, TNF-α, TGF-beta, IFN-γ, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof.

    摘要翻译： 公开了含有B7-H4多肽的融合蛋白。 B7-H4融合蛋白可以包括全长B7-H4多肽，或可以含有全长B7-H4多肽的片段，包括B7-H4多肽的一些或全部细胞外结构域。 还公开了使用融合蛋白来下调T细胞活化和治疗炎性和自身免疫性疾病和病症的方法。 B7-H4融合蛋白可用于通过抑制或减少Th1，Th17，Th22和/或分泌或引起其他细胞的其他细胞的分化，增殖，活性和/或细胞因子产生和/或分泌来治疗炎症 包括但不限于IL-1和bgr; TNF-α，TGF-β，IFN-γ，IL-17，IL-6，IL-23，IL-22，IL-21， 和MMPs; 或增强Treg的IL-10分泌，增加Treg的分化，增加Treg的数量或其组合。

    Split window scatter correction
    5.
    发明授权
    Split window scatter correction 失效
    拆分窗口散射校正

    公开(公告)号：US5633500A

    公开(公告)日：1997-05-27

    申请号：US561936

    申请日：1995-11-22

    申请人： Hugh T. Morgan ,  Gary G. Jarkewicz ,  Piotr J. Maniawski ,  Stephen D. Miller

    发明人： Hugh T. Morgan ,  Gary G. Jarkewicz ,  Piotr J. Maniawski ,  Stephen D. Miller

    IPC分类号： G01T1/164 ,  G01T1/161

    CPC分类号： G01T1/1647 ,  G01T1/1642

    摘要： A method of scatter correction for use with gamma cameras includes the steps of detecting and producing a first count value indicative of gamma radiation falling within a first energy range generally associated with a radionuclide photopeak. Gamma radiation falling within second and third energy ranges is also detected and a corresponding count produced. The second and third ranges are above and below the photopeak, respectively. The location of the second and third energy ranges is determined based on the energy resolution of the gamma camera such that a predetermined percentage of the radiation falling within the second and third ranges results from primary radiation. The second and third energy ranges may be located such that they are non-contiguous with the first energy range. Based on the count of radiation falling within the second and third ranges, the scatter radiation falling within the first energy range can be estimated, and the first count value corrected. The method is suitable for use with radionuclides having multiple closely spaced photopeaks as well as with multiple widely spaced photopeaks.

    摘要翻译： 用于伽马照相机的散射校正方法包括以下步骤：检测并产生指示伽马辐射落在通常与放射性核素光峰相关联的第一能量范围内的第一计数值。 也检测到落在第二和第三能量范围内的伽马辐射，并产生相应的计数。 第二和第三范围分别在光峰之上和之下。 基于γ相机的能量分辨率来确定第二和第三能量范围的位置，使得落入第二和第三范围内的预定百分比的辐射源自初级辐射。 第二和第三能量范围可以被定位成使得它们与第一能量范围不连续。 基于落在第二和第三范围内的辐射计数，可以估计落在第一能量范围内的散射辐射，并且校正第一计数值。 该方法适用于具有多个紧密间隔的光峰的放射性核素以及多个宽间隔的光峰。

    Gamma camera system having multi-resolution detectors
    7.
    发明授权
    Gamma camera system having multi-resolution detectors 失效
    伽玛相机系统具有多分辨率检测器

    公开(公告)号：US06177675B1

    公开(公告)日：2001-01-23

    申请号：US09064458

    申请日：1998-04-22

    申请人： Daniel Gagnon ,  Stephen D. Miller ,  William G. Hawkins

    发明人： Daniel Gagnon ,  Stephen D. Miller ,  William G. Hawkins

    IPC分类号： G01T1166

    CPC分类号： G01T1/1647

    摘要： A gamma camera system includes a rotatable gantry supporting multiple detector heads each capable of receiving radiation from a region of interest of a subject disposed in an examination region. Each of the detector heads include a collimator which substantially defines the resolution and sensitivity of the respective detector head. At least two of the detector heads include collimators providing different resolution. Preferably, one of the collimators provides a detector head with substantially high resolution and another provides a detector head with substantially high sensitivity. An operator selectively combines image data detected by each of the multiple detector heads. If desired, the operator combine the image data from the multiple detector heads in a variety of manners to obtain images of various resolution and sensitivity from a single imaging procedure. The operator may also selectively weight the contribution that the image data from each of the detector heads has in the overall image. As yet another option, the operator may choose to combine only a high energy portion of the image data so as to minimize the amount of scatter events which are included in a final image.

    摘要翻译： 伽马照相机系统包括可旋转机架，其支撑多个检测器头，每个检测器能够接收来自设置在检查区域中的对象的感兴趣区域的辐射。 每个检测器头包括基本上限定相应检测器头的分辨率和灵敏度的准直器。 至少两个检测器头包括提供不同分辨率的准直仪。 优选地，准直仪之一提供具有基本上高分辨率的检测器头，并且另一个提供具有基本上高灵敏度的检测器头。 操作者选择性地组合由多个检测器头中的每一个检测的图像数据。 如果需要，操作员以各种方式组合来自多个探测器头的图像数据，以从单个成像过程获得各种分辨率和灵敏度的图像。 操作者还可以选择性地加权来自每个检测器头部的图像数据对整个图像的贡献。 作为另一选择，操作者可以选择仅组合图像数据的高能量部分，以便最小化包括在最终图像中的散射事件的量。

    Transmission attenuation correction method for PET and SPECT
    9.
    发明授权
    Transmission attenuation correction method for PET and SPECT 失效
    PET和SPECT传输衰减校正方法

    公开(公告)号：US06429434B1

    公开(公告)日：2002-08-06

    申请号：US09398497

    申请日：1999-09-17

    申请人： Charles C. Watson ,  Stephen D. Miller ,  Ronald Nutt ,  Michael E. Casey ,  James J. Hamill

    发明人： Charles C. Watson ,  Stephen D. Miller ,  Ronald Nutt ,  Michael E. Casey ,  James J. Hamill

    IPC分类号： G01T1166

    CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01T1/1648 ,  G21K1/02

    摘要： A transmission source serves to detect activity from a radiation source for correcting attenuation in either PET mode or SPECT mode. The transmission source includes a detector dedicated to collecting attenuation data in PET mode. A collimated radiation source and a detector are positioned with respect to a tomography device such that only a selected strip of the imaging detector of the tomograph is illuminated such that events unrelated to the attenuation are eliminated. The transmission source can either be a coincidence transmission source or a singles transmission source and includes a collimator in which is disposed a radiation source. An opening is defined by the collimator for exposing a selected portion of the imaging detectors of the tomograph device. Positioned behind the radiation source, relative to the imaging detectors, is the dedicated attenuation detector. In a dual head tomograph device, one transmission source of the present invention is disposed opposite each bank of imaging detectors. The sources and the associated collimators are positioned to the side of each head at a slight angle relative to the respective head. The sources and detectors are fixed relative to the imaging heads. In order to obtain full coverage of the field of view (FOV) in the same manner as for an emission scan, the heads and sources are rotated about the center of the camera. In SPECT mode, the point source is selected to have sufficiently high energy to shine through the patient and the collimators associated with the imaging detector.

    摘要翻译： 传输源用于检测来自辐射源的活动以校正PET模式或SPECT模式中的衰减。 传输源包括专用于在PET模式下收集衰减数据的检测器。 准直辐射源和检测器相对于断层摄影装置定位，使得只有层析成像仪的成像检测器的选定条带被照亮，从而消除与衰减无关的事件。 传输源可以是重合传输源或单个传输源，并且包括准直仪，其中设置有辐射源。 由准直器限定开口以暴露层析成像装置的成像检测器的选定部分。 相对于成像检测器定位在辐射源之后，是专用的衰减检测器。 在双头断层摄影装置中，本发明的一个发射源与每一组成像检测器相对设置。 源和相关联的准直仪相对于相应的头部以相当小的角度定位在每个头部的侧面。 源和检测器相对于成像头是固定的。 为了以与发射扫描相同的方式获得视场（FOV）的全面覆盖，头部和源围绕照相机的中心旋转。 在SPECT模式中，点源被选择为具有足够高的能量以照射通过患者和与成像检测器相关联的准直仪。

    Insulating material
    10.
    发明授权
    Insulating material 失效
    绝缘材料

    公开(公告)号：US4550046A

    公开(公告)日：1985-10-29

    申请号：US638427

    申请日：1984-08-07

    申请人： Stephen D. Miller

    发明人： Stephen D. Miller

    IPC分类号： B29D24/00 ,  B29D99/00 ,  B32B3/12 ,  E04B1/78

    CPC分类号： B29D99/0089 ,  B29D24/005 ,  B32B3/12 ,  E04B1/78 ,  Y10S428/92 ,  Y10T428/24149 ,  Y10T428/24174 ,  Y10T428/24322

    摘要： A composite insulating material which is comprised of one or more layers of open ended cells formed from flexible thin plastic sheet, and may be fastened to one or more cover sheets. The material is flexible enough to be worn as clothing and derives its insulating properties by reducing thermal conducting paths and areas, by introducing numerous controlled geometry air cells between the heat source and inner layer to further lower conductivity and inhibit convection currents and, by absorbing radiant thermal energy within the cell walls thereby reducing heat transmission by radiation. Metallized reflecting layers are not required to achieve high insulating efficiency.

    摘要翻译： 复合绝缘材料，其由柔性薄塑料片形成的一层或多层开口单元组成，并且可以被紧固到一个或多个覆盖片。 通过在热源和内层之间引入许多受控制的几何空气单元，该材料具有足够的柔韧性，能够作为服装穿着，并通过减少导热路径和面积来获得其绝缘性能，以进一步降低导电性并抑制对流，并通过吸收辐射 细胞壁内的热能由此减少辐射的热传递。 金属化反射层不需要达到高绝缘效率。