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    Enhanced expression and stability regions
    1.
    发明授权
    Enhanced expression and stability regions 有权
    增强表达和稳定性区域

    公开(公告)号：US07771997B2

    公开(公告)日：2010-08-10

    申请号：US12132846

    申请日：2008-06-04

    申请人： Gang Chen ,  Robert Babb ,  James P. Fandl

    发明人： Gang Chen ,  Robert Babb ,  James P. Fandl

    IPC分类号： C12N5/10

    CPC分类号： C12N15/85 ,  C07K16/00 ,  C07K2319/30 ,  C12N15/86 ,  C12N2740/10043 ,  C12N2800/30 ,  C12N2840/203 ,  C12P21/02

    摘要： Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.

    摘要翻译： 提供了用于在真核系统中表达的表达增强核苷酸序列，其允许重组蛋白在真核细胞中增强和稳定表达。 提供增强的表达和稳定区（EESYR）用于在真核细胞中表达感兴趣的基因。 提供染色体基因座，序列和载体用于真核细胞中基因的增强和稳定表达。

    Enhanced Expression and Stability Regions
    2.
    发明申请
    Enhanced Expression and Stability Regions 有权
    增强表达和稳定性区域

    公开(公告)号：US20090124005A1

    公开(公告)日：2009-05-14

    申请号：US12132846

    申请日：2008-06-04

    申请人： Gang CHEN ,  Robert Babb ,  James P. Fandl

    发明人： Gang CHEN ,  Robert Babb ,  James P. Fandl

    IPC分类号： C12N5/10 ,  C12N5/06

    CPC分类号： C12N15/85 ,  C07K16/00 ,  C07K2319/30 ,  C12N15/86 ,  C12N2740/10043 ,  C12N2800/30 ,  C12N2840/203 ,  C12P21/02

    摘要： Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.

    摘要翻译： 提供了用于在真核系统中表达的表达增强核苷酸序列，其允许重组蛋白在真核细胞中增强和稳定表达。 提供增强的表达和稳定区（EESYR）用于在真核细胞中表达感兴趣的基因。 提供染色体基因座，序列和载体用于真核细胞中基因的增强和稳定表达。

    ENHANCED EXPRESSION AND STABILITY REGIONS
    4.
    发明申请
    ENHANCED EXPRESSION AND STABILITY REGIONS 有权
    增强表达和稳定性领域

    公开(公告)号：US20100291626A1

    公开(公告)日：2010-11-18

    申请号：US12793898

    申请日：2010-06-04

    申请人： Gang CHEN ,  Robert Babb ,  James P. Fandl

    发明人： Gang CHEN ,  Robert Babb ,  James P. Fandl

    IPC分类号： C12P21/00 ,  C12N5/10

    CPC分类号： C12N15/85 ,  C07K16/00 ,  C07K2319/30 ,  C12N15/86 ,  C12N2740/10043 ,  C12N2800/30 ,  C12N2840/203 ,  C12P21/02

    摘要： Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.

    摘要翻译： 提供了用于在真核系统中表达的表达增强核苷酸序列，其允许重组蛋白在真核细胞中增强和稳定表达。 提供增强的表达和稳定区（EESYR）用于在真核细胞中表达感兴趣的基因。 提供染色体基因座，序列和载体用于真核细胞中基因的增强和稳定表达。

    Common Light Chain Mouse
    6.
    发明申请
    Common Light Chain Mouse 审中-公开
    普通轻链鼠标

    公开(公告)号：US20120192300A1

    公开(公告)日：2012-07-26

    申请号：US13412936

    申请日：2012-03-06

    申请人： Robert Babb ,  John McWhirter ,  Lynn MacDonald ,  Sean Stevens ,  Samuel Davis ,  David R. Buckler ,  Karolina A. Hosiawa ,  Andrew J. Murphy

    发明人： Robert Babb ,  John McWhirter ,  Lynn MacDonald ,  Sean Stevens ,  Samuel Davis ,  David R. Buckler ,  Karolina A. Hosiawa ,  Andrew J. Murphy

    IPC分类号： A01K67/027

    摘要： A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making light chain variable regions in mice, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, are provided.

    摘要翻译： 提供遗传修饰的小鼠，其中小鼠表达免疫球蛋白轻链总谱，其特征在于有限数量的轻链可变结构域。 提供的小鼠在其种系中仅来自有限谱系的一个或几个免疫球蛋白轻链可变结构域。 提供了在小鼠中制备轻链可变区的方法，包括人轻链可变区。 提供了适用于多特异性结合蛋白（例如双特异性抗体）的人可变区的方法。

    Systems and methods for identifying and displaying dependencies
    7.
    发明申请
    Systems and methods for identifying and displaying dependencies 有权
    用于识别和显示依赖关系的系统和方法

    公开(公告)号：US20070162903A1

    公开(公告)日：2007-07-12

    申请号：US11326902

    申请日：2006-01-06

    申请人： Robert Babb ,  Michael Parry ,  Jason Byassee ,  Ted Meyers ,  David Mooney

    发明人： Robert Babb ,  Michael Parry ,  Jason Byassee ,  Ted Meyers ,  David Mooney

    IPC分类号： G06F9/45 ,  G06F9/44

    CPC分类号： G06F8/75

    摘要： Systems and methods are provided for identifying and displaying dependencies. One aspect of the invention comprises a system having a dependency parser that parses components of a system with dependencies and generates a plurality of component dependency pairs associated with the components, and a component dependency graph generator that generates a dependency directed graph from the plurality of dependency pairs. The system further includes a component levels and cycles analyzer that traverses the dependency directed graph to identify dependencies, strong components and component dependency levels associated with the dependency directed graph, and a graphical user interface that provides a tree view illustrating a dependency tree of the identified dependencies over the identified component dependency levels.

    摘要翻译： 提供了用于识别和显示依赖关系的系统和方法。 本发明的一个方面包括具有依赖性解析器的系统，所述依赖性解析器解析具有依赖性的系统的组件，并且生成与所述组件相关联的多个组件依赖对，以及组件依赖图生成器，其从所述多个依赖关系生成依赖性有向图 对。 该系统还包括遍历依赖性有向图以识别与依赖性有向图相关联的依赖性，强组件和组件依赖性级别的组件级别和循环分析器，以及图形用户界面，其提供示出所识别的依赖关系的依赖关系树 依赖于所识别的组件依赖关系。