公开(公告)号：US20090124005A1

公开(公告)日：2009-05-14

申请号：US12132846

申请日：2008-06-04

申请人： Gang CHEN ,  Robert Babb ,  James P. Fandl

发明人： Gang CHEN ,  Robert Babb ,  James P. Fandl

IPC分类号： C12N5/10 ,  C12N5/06

CPC分类号： C12N15/85 ,  C07K16/00 ,  C07K2319/30 ,  C12N15/86 ,  C12N2740/10043 ,  C12N2800/30 ,  C12N2840/203 ,  C12P21/02

摘要： Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.

摘要翻译： 提供了用于在真核系统中表达的表达增强核苷酸序列，其允许重组蛋白在真核细胞中增强和稳定表达。 提供增强的表达和稳定区（EESYR）用于在真核细胞中表达感兴趣的基因。 提供染色体基因座，序列和载体用于真核细胞中基因的增强和稳定表达。

公开(公告)号：US20100291626A1

公开(公告)日：2010-11-18

申请号：US12793898

申请日：2010-06-04

申请人： Gang CHEN ,  Robert Babb ,  James P. Fandl

发明人： Gang CHEN ,  Robert Babb ,  James P. Fandl

IPC分类号： C12P21/00 ,  C12N5/10

CPC分类号： C12N15/85 ,  C07K16/00 ,  C07K2319/30 ,  C12N15/86 ,  C12N2740/10043 ,  C12N2800/30 ,  C12N2840/203 ,  C12P21/02

摘要： Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.

摘要翻译： 提供了用于在真核系统中表达的表达增强核苷酸序列，其允许重组蛋白在真核细胞中增强和稳定表达。 提供增强的表达和稳定区（EESYR）用于在真核细胞中表达感兴趣的基因。 提供染色体基因座，序列和载体用于真核细胞中基因的增强和稳定表达。

公开(公告)号：US20100304436A1

公开(公告)日：2010-12-02

申请号：US12791637

申请日：2010-06-01

申请人： Gang CHEN ,  Darya Burakov ,  James P. Fandl

发明人： Gang CHEN ,  Darya Burakov ,  James P. Fandl

IPC分类号： C12P21/00 ,  C07H21/04 ,  C12N5/10

CPC分类号： C12P21/005 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2866 ,  C07K2317/14 ,  C07K2317/41 ,  C12N9/0006 ,  C12N15/00 ,  C12Y101/01271 ,  Y02P20/52

摘要： An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a combination thereof is provided. Cells having a gene encoding a modified FX protein are provided, wherein the cells exhibit a reduced ability to fucosylate a glycoprotein at a first temperature, but exhibit the ability to fucosylate the glycoprotein at a second temperature. Methods and compositions for making glycoproteins with reduced fucosylation are provided.

摘要翻译： 提供了编码FX蛋白的分离核酸，其在79位具有丝氨酸，在90位具有赖氨酸，136位的亮氨酸，211位的精氨酸，289位的丝氨酸及其组合。 提供具有编码经修饰的FX蛋白的基因的细胞，其中细胞在第一温度下表现出降低糖蛋白岩藻糖化能力，但在第二温度下表现出对糖蛋白的岩藻糖化能力。 提供了用于制备具有降低的岩藻糖基化的糖蛋白的方法和组合物。

公开(公告)号：US20240182549A1

公开(公告)日：2024-06-06

申请号：US18284756

申请日：2022-03-31

申请人： Sachdev SIDHU ,  Shane MIERSCH ,  Gang CHEN ,  Jonathan LABRIOLA

发明人： Sachdev SIDHU ,  Shane MIERSCH ,  Gang CHEN ,  Jonathan LABRIOLA

IPC分类号： C07K16/10 ,  C07K14/47

CPC分类号： C07K16/1003 ,  C07K14/4703 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2319/30

摘要： Described herein are peptides and peptide-antibody fusions that bind to the SARS-CoV-2 S protein and the receptor binding domain (RED), and methods for using the compositions containing these antibodies in the treatment of COVID-19, Specifically, we developed novel CoV-2 S protein binding peptides making use of a naïve phage-displayed 16mer peptide library—wherein the CoV-2 S protein binding peptides bind epitopes in both the RBD and S protein outside of the RBD. In addition, we show that fusion of these peptides to the N-terminus of nAbs improves their apparent affinity, potency and breadth of neutralization, without compromising their developability profile, Thus, these peptides represent a novel class of SARS-CoV-2 S protein binders, which can be formatted in various ways to improve functional properties of nAbs to be used in the treatment of many different diseases.

公开(公告)号：US20100035134A1

公开(公告)日：2010-02-11

申请号：US12400785

申请日：2009-03-09

申请人： Gang CHEN

发明人： Gang CHEN

IPC分类号： H01M2/10

CPC分类号： H01M2/1044

摘要： A housing (610, 620) for a button-type battery (β) includes a cavity with resilient conductive terminals (300, 400) therein and a door (500) opposite the terminals (300, 400).When a battery (β) is pushed inside the cavity and the door (500) is moved to its closed position, the resilient terminals (300, 400) hold the battery (β) in place, applying a force urging the battery (β) against the door (500) to better maintain electrical contact.When the door (500) is moved to its open position, the resilient terminals (300, 400) push the battery (β) at least one fifth of its diameter out of the cavity, so a user can pull out the battery (β) by hand and change the battery (β) easily.

摘要翻译： 用于按钮式电池（β）的壳体（610,620）包括其中具有弹性导电端子（300,400）的空腔和与端子（300,400）相对的门（500）。 当电池（beta）被推入空腔内并且门（500）移动到其关闭位置时，弹性端子（300,400）将电池（β）保持在适当位置，施加推动电池（β）的力， 对门（500）更好地保持电气接触。 当门（500）移动到其打开位置时，弹性端子（300,400）将其直径的至少五分之一的电池（β）推出空腔，使得用户可以拉出电池（β） 手动更换电池（测试版）。

公开(公告)号：US20240024346A1

公开(公告)日：2024-01-25

申请号：US18021709

申请日：2021-11-25

申请人： RISEN (SUZHOU) PHARMA TECH CO., LTD. ,  Jiasheng LU ,  Gang CHEN ,  Qiguo ZHANG ,  Xianqi KONG ,  Dawei CHEN ,  Chuanhao HUANG ,  Xingwu ZHU ,  Yuhua ZHANG

发明人： Jiasheng LU ,  Gang CHEN ,  Qiguo ZHANG ,  Xianqi KONG ,  Dawei CHEN ,  Chuanhao HUANG ,  Xingwu ZHU ,  Yuhua ZHANG

IPC分类号： A61K31/7076 ,  C07H19/20 ,  A61K45/06

CPC分类号： A61K31/7076 ,  A61K45/06 ,  C07H19/20

摘要： CD73 (also known as ecto-5′-nucleotidase) inhibitor compounds are provided, as well as compositions and uses thereof for treating or preventing CD73-associated or related diseases, disorders and conditions, including cancer- and immune-related disorders. CD73 inhibitor compounds include compounds having the structure set forth in Formula I′ and pharmaceutically acceptable esters or salts thereof.

公开(公告)号：US20210123496A1

公开(公告)日：2021-04-29

申请号：US17139074

申请日：2020-12-31

申请人： Gang CHEN

发明人： Gang CHEN

IPC分类号： F16F13/00 ,  F16F9/34 ,  F16F9/53 ,  F16F9/512

摘要： The present invention relates to a support damping apparatus and a vehicle using the support damping apparatus. The support damping apparatus includes a support spring, a force measuring element and a damper. The damper includes a hydraulic cylinder, a valve assembly and a control assembly. The force measuring element measures a support force value of the support damping apparatus for a supported object, and compares the support force value with a target force value. The damping force value of the damper is controlled by the control assembly in a mechanical, hydraulic or electric manner according to a comparison result so as to adjust the support force value of the support damping apparatus, so that the support force value of the support damping apparatus is equal to or approximate to the target force value. The present invention also relates to a vehicle with the support damping apparatus.

公开(公告)号：US20200251023A1

公开(公告)日：2020-08-06

申请号：US16265254

申请日：2019-02-01

申请人： Gang CHEN

发明人： Gang CHEN

IPC分类号： G09F3/10 ,  G09F3/02 ,  B32B7/12 ,  B32B7/06

摘要： The invention discloses a screen sticker comprising a backside coated release paper and a screen printed label, wherein the screen printed label comprises a removable glue layer, a filler layer, a mesh layer and a frosted glue layer. A method for making the screen sticker comprises the steps of: spreading and flattening the backside coated release paper on a work table; printing the desired pattern on the backside coated release paper; laying the mesh layer on the filler layer and then printing the filler layer on the removable glue layer with the pattern; printing the frosted glue layer on the mesh layer; and cutting the resulting screen sticker. The screen sticker of the invention can be repeatedly cleaned for use.

公开(公告)号：US20090063623A1

公开(公告)日：2009-03-05

申请号：US11849207

申请日：2007-08-31

申请人： Michael Wayne BROWN ,  Gang CHEN ,  Hua CHENG ,  Christopher Shane CLAUSSEN ,  Xin HUANG ,  Xiaochun MEI ,  Charles James REDLIN ,  Hai Yun ZHAO

发明人： Michael Wayne BROWN ,  Gang CHEN ,  Hua CHENG ,  Christopher Shane CLAUSSEN ,  Xin HUANG ,  Xiaochun MEI ,  Charles James REDLIN ,  Hai Yun ZHAO

IPC分类号： G06F15/16

CPC分类号： H04L67/16 ,  G06F9/465 ,  G06F2209/462 ,  H04L29/12113 ,  H04L61/1541 ,  H04L67/1002 ,  H04L67/1008 ,  H04L67/1017

摘要： Provided are a method, system, and article of manufacture for determining connection information to use to access an artifact from an application on a remote server. A request is received in a local server for an artifact at a target application executing on a remote server. A determination is made as to whether a local repository includes connection information on the remote server. The connection information is used to communicate the request for the artifact to the remote server over a network. The connection information is accessed from the local repository in response to determining that the local repository includes the connection information for the remote server. A determination is made as to whether a common repository is available to provide the connection information for the remote server in response to determining that the local repository does not include the connection information for the remote server. Communication is made to the common repository over the network to access the connection information for the remote server in response to determining that the common repository is available to provide the connection information.

摘要翻译： 提供了一种用于确定用于从远程服务器上的应用程序访问工件的连接信息的方法，系统和制品。 在本地服务器中收到在远程服务器上执行的目标应用程序上的工件的请求。 确定本地存储库是否包括远程服务器上的连接信息。 连接信息用于通过网络将工件的请求传送到远程服务器。 响应于确定本地存储库包括远程服务器的连接信息，从本地存储库访问连接信息。 响应于确定本地存储库不包括远程服务器的连接信息，确定公用存储库是否可用于为远程服务器提供连接信息。 响应于确定公共存储库可用于提供连接信息，通过网络对通用存储库进行通信以访问远程服务器的连接信息。

公开(公告)号：US20220190793A1

公开(公告)日：2022-06-16

申请号：US17027708

申请日：2020-09-22

申请人： Gang CHEN ,  Yunfang BAI

发明人： Gang CHEN ,  Yunfang BAI

IPC分类号： H03F3/193 ,  H03F3/213 ,  H03F3/60

摘要： Disclosed in the present invention are a balanced radio frequency power amplifier, a chip and a communication terminal. The radio frequency power amplifier divides, by means of a 90-degree power splitter unit, a radio frequency input signal into two equal-amplitude signals having a phase difference of 90 degrees, the two radio frequency input signals are amplified and then inputted into an adjustable 90-degree power combiner, and the values of a adjustable capacitor and an adjustable resistor in the adjustable 90-degree power combiner are controlled by means of a control unit, so as to synthesize the two radio frequency input signals into one radio frequency input signal when the phase difference and amplitude difference of the two signals at different frequencies are the smallest, and to input the radio frequency input signal into a circuit of the next stage by means of a specific radio frequency transmission path.