公开(公告)号：US20050000808A1

公开(公告)日：2005-01-06

申请号：US10778685

申请日：2004-02-12

申请人： Gang Cui ,  Jae-Hyun Yoo ,  Moon-Hwan Kim ,  Ju-Yong Kim ,  Jung-Hee Uhm ,  Hakhyun Nam ,  Geun-Sig Cha

发明人： Gang Cui ,  Jae-Hyun Yoo ,  Moon-Hwan Kim ,  Ju-Yong Kim ,  Jung-Hee Uhm ,  Hakhyun Nam ,  Geun-Sig Cha

IPC分类号： G01N27/327 ,  C12Q1/00 ,  C12Q1/25 ,  G01N27/416 ,  G01N1/00 ,  C12M1/00 ,  C12M1/42

CPC分类号： C12Q1/004 ,  C12Q1/001

摘要： There is provided the reagent layer composition that can substantially reduce the measurement bias arising from hematocrits. The addition of fatty acid (4-20 carbons) and quaternary ammonium salt to a commonly used reagent layer composition composed of an enzyme, an electron transfer mediator, and several water soluble polymers not only reduce the hematocrit level-dependent bias but also provide very stable performance for an extended period of time. Disclosed are also various types of sub microliter sample volume electrochemical biosensors that are suitable to use with the reagent layer composition of present invention.

摘要翻译： 提供了可以显着降低由血细胞比容引起的测量偏差的试剂层组合物。 向酶，电子传递介质和几种水溶性聚合物组成的常用试剂​​层组合物中加入脂肪酸（4-20碳）和季铵盐不仅可降低血细胞比容水平依赖性偏倚， 稳定的性能在较长的一段时间。 还公开了适用于本发明的试剂层组合物的各种类型的微微升样品体积电化学生物传感器。

公开(公告)号：US07288174B2

公开(公告)日：2007-10-30

申请号：US10778685

申请日：2004-02-12

申请人： Gang Cui ,  Jae-Hyun Yoo ,  Moon-Hwan Kim ,  Ju-Yong Kim ,  Jung-Hee Uhm ,  Hakhyun Nam ,  Geun-Sig Cha

发明人： Gang Cui ,  Jae-Hyun Yoo ,  Moon-Hwan Kim ,  Ju-Yong Kim ,  Jung-Hee Uhm ,  Hakhyun Nam ,  Geun-Sig Cha

IPC分类号： G01N27/327

CPC分类号： C12Q1/004 ,  C12Q1/001

摘要： There is provided the reagent layer composition that can substantially reduce the measurement bias arising from hematocrits. The addition of fatty acid (4-20 carbons) and quaternary ammonium salt to a commonly used reagent layer composition composed of an enzyme, an electron transfer mediator, and several water soluble polymers not only reduce the hematocrit level-dependent bias but also provide very stable performance for an extended period of time. Disclosed are also various types of sub microliter sample volume electrochemical biosensors that are suitable to use with the reagent layer composition of present invention.

摘要翻译： 提供了可以显着降低由血细胞比容引起的测量偏差的试剂层组合物。 向酶，电子传递介质和几种水溶性聚合物组成的常用试剂​​层组合物中加入脂肪酸（4-20碳）和季铵盐不仅可降低血细胞比容水平依赖性偏倚， 稳定的性能在较长的一段时间。 还公开了适用于本发明的试剂层组合物的各种类型的微微升样品体积电化学生物传感器。