公开(公告)号：US07288174B2

公开(公告)日：2007-10-30

申请号：US10778685

申请日：2004-02-12

申请人： Gang Cui ,  Jae-Hyun Yoo ,  Moon-Hwan Kim ,  Ju-Yong Kim ,  Jung-Hee Uhm ,  Hakhyun Nam ,  Geun-Sig Cha

发明人： Gang Cui ,  Jae-Hyun Yoo ,  Moon-Hwan Kim ,  Ju-Yong Kim ,  Jung-Hee Uhm ,  Hakhyun Nam ,  Geun-Sig Cha

IPC分类号： G01N27/327

CPC分类号： C12Q1/004 ,  C12Q1/001

摘要： There is provided the reagent layer composition that can substantially reduce the measurement bias arising from hematocrits. The addition of fatty acid (4-20 carbons) and quaternary ammonium salt to a commonly used reagent layer composition composed of an enzyme, an electron transfer mediator, and several water soluble polymers not only reduce the hematocrit level-dependent bias but also provide very stable performance for an extended period of time. Disclosed are also various types of sub microliter sample volume electrochemical biosensors that are suitable to use with the reagent layer composition of present invention.

摘要翻译： 提供了可以显着降低由血细胞比容引起的测量偏差的试剂层组合物。 向酶，电子传递介质和几种水溶性聚合物组成的常用试剂​​层组合物中加入脂肪酸（4-20碳）和季铵盐不仅可降低血细胞比容水平依赖性偏倚， 稳定的性能在较长的一段时间。 还公开了适用于本发明的试剂层组合物的各种类型的微微升样品体积电化学生物传感器。

公开(公告)号：US20050000808A1

公开(公告)日：2005-01-06

申请号：US10778685

申请日：2004-02-12

申请人： Gang Cui ,  Jae-Hyun Yoo ,  Moon-Hwan Kim ,  Ju-Yong Kim ,  Jung-Hee Uhm ,  Hakhyun Nam ,  Geun-Sig Cha

发明人： Gang Cui ,  Jae-Hyun Yoo ,  Moon-Hwan Kim ,  Ju-Yong Kim ,  Jung-Hee Uhm ,  Hakhyun Nam ,  Geun-Sig Cha

IPC分类号： G01N27/327 ,  C12Q1/00 ,  C12Q1/25 ,  G01N27/416 ,  G01N1/00 ,  C12M1/00 ,  C12M1/42

CPC分类号： C12Q1/004 ,  C12Q1/001

摘要： There is provided the reagent layer composition that can substantially reduce the measurement bias arising from hematocrits. The addition of fatty acid (4-20 carbons) and quaternary ammonium salt to a commonly used reagent layer composition composed of an enzyme, an electron transfer mediator, and several water soluble polymers not only reduce the hematocrit level-dependent bias but also provide very stable performance for an extended period of time. Disclosed are also various types of sub microliter sample volume electrochemical biosensors that are suitable to use with the reagent layer composition of present invention.

摘要翻译： 提供了可以显着降低由血细胞比容引起的测量偏差的试剂层组合物。 向酶，电子传递介质和几种水溶性聚合物组成的常用试剂​​层组合物中加入脂肪酸（4-20碳）和季铵盐不仅可降低血细胞比容水平依赖性偏倚， 稳定的性能在较长的一段时间。 还公开了适用于本发明的试剂层组合物的各种类型的微微升样品体积电化学生物传感器。

公开(公告)号：US07455756B2

公开(公告)日：2008-11-25

申请号：US10476634

申请日：2002-05-30

申请人： Moon-Hee Choi ,  Gang Cui ,  Jae-Hyun Yoo ,  Ho-Choll Cho ,  Min-Sun Kim ,  Fenghua Zhang ,  Hakhyun Nam ,  Geun-Sig Cha

发明人： Moon-Hee Choi ,  Gang Cui ,  Jae-Hyun Yoo ,  Ho-Choll Cho ,  Min-Sun Kim ,  Fenghua Zhang ,  Hakhyun Nam ,  Geun-Sig Cha

IPC分类号： G01N27/327

CPC分类号： B82Y30/00 ,  G01N27/3272 ,  G01N33/5438

摘要： A biosensor, for use in measurement of an analyte, includes a microporous membrane support, a first electrode system, a second electrode system, and a pair of insulating films. The first electrode system is formed on the surface of the microporous membrane support and the second electrode system is formed on the opposite surface of the microporous membrane support. The biosensor enables a rapid, simple, separation-free, and selective detection of the analytes. The biosensor does not require any bulky additional electrode, so that miniaturization, point-of-car testing, and disposability can be achieved.

摘要翻译： 用于测定分析物的生物传感器包括微孔膜载体，第一电极系统，第二电极系统和一对绝缘膜。 第一电极系统形成在微孔膜支撑体的表面上，第二电极系统形成在微多孔膜支撑体的相对表面上。 生物传感器可以快速，简单，无分离和选择性地检测分析物。 生物传感器不需要任何庞大的附加电极，从而可以实现小型化，汽车点测试和可处理性。

公开(公告)号：US07704747B2

公开(公告)日：2010-04-27

申请号：US10825253

申请日：2004-04-15

申请人： Moon Hwan Kim ,  Keun Ki Kim ,  Gang Cui ,  Hakhyun Nam ,  Geun-Sig Cha

发明人： Moon Hwan Kim ,  Keun Ki Kim ,  Gang Cui ,  Hakhyun Nam ,  Geun-Sig Cha

IPC分类号： G01N33/48 ,  G01N33/00

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/157 ,  A61B2562/0295 ,  G01N33/48785 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/144444

摘要： Disclosed herein is a dual blood glucose meter. The dual blood glucose meter includes a meter body, a measurement strip, a variety of electronic parts and upper and lower strip receiving ports. The meter body is provided with a liquid crystal display panel on the front thereof to display measured numerical values and various pieces of pictorial information. The measurement strip is brought into contact with blood at a blood collection spot so as to measure blood glucose of the blood. The electronic parts are used to measure the blood glucose of the blood. The upper and lower strip receiving ports are formed at upper and lower ends of the meter body to receive the measurement strip, and are each electrically connected to the electric parts.

摘要翻译： 这里公开了双血糖计。 双血糖仪包括仪表体，测量条，各种电子部件和上下条接收口。 仪表主体在其前面设置有液晶显示面板，以显示测量的数值和各种图形信息。 测量条与血液收集点处的血液接触，以测量血液的血糖。 电子部件用于测量血液中的血糖。 上下条接收端口形成在仪表主体的上端和下端以接收测量条，并且各自电连接到电气部件。

公开(公告)号：US06210907B1

公开(公告)日：2001-04-03

申请号：US09381788

申请日：1999-09-22

申请人： Geun-Sig Cha

发明人： Geun-Sig Cha

IPC分类号： G01N3353

CPC分类号： C12Q1/60 ,  C12Q1/005 ,  G01N27/3274 ,  G01N30/64 ,  G01N2030/285 ,  G01N2030/8822 ,  Y10S435/962 ,  Y10S436/806

摘要： The present invention relates to a measuring device which comprises electrodes fabricated on porous membrane substrate in which the sample migrates chromatographically; and the method of quantifying material in the sample by using the device. The sample material for measuring can be quantified by the measuring device of this invention, which is consists pretreatment bands in the lower part of porous membrane substrate and electrodes in the upper prt of pretreatment bands, by the procedure as foolows: The sample material for measuring is chromatographically migrated in the porous membrane substrate by applying the sample on the lower part of the porous membrane substrate; and then the changes of electric signal by the material at the electrode are measured to quantify the material. The analyzing method using the measuring device of this invention has merits that no additional preparation of the sample is needed, simple analyzing process, quantitative analysis of the material in a short time, and the economical efficiency because of the dispensability of skilled personnel due to easy manipulation.

摘要翻译： 本发明涉及一种测量装置，其包括在多孔膜基底上制造的电极，其中样品在色谱上迁移; 以及通过使用该装置来量化样品中的材料的方法。 用于测量的样品材料可以通过本发明的测量装置来定量，其包括在多孔膜基材的下部中的预处理带和预处理带的上部电极中的电极，其方法如下：用于测量的样品材料 通过将样品涂布在多孔膜基材的下部上，在多孔膜基材中进行色谱迁移。 然后测量电极处的材料的电信号变化量化材料。 使用本发明的测量装置的分析方法的优点在于，不需要额外的样品制备，简单的分析过程，在短时间内对材料进行定量分析，并且由于易于使用的技术人员的可分配性而具有经济效率 操纵。

公开(公告)号：US5417835A

公开(公告)日：1995-05-23

申请号：US137373

申请日：1993-10-14

申请人： Richard B. Brown ,  Geun-Sig Cha

发明人： Richard B. Brown ,  Geun-Sig Cha

IPC分类号： G01N27/333 ,  G01N27/26

CPC分类号： G01N27/3335 ,  Y10S435/817

摘要： A polyimide matrix is employed to form a substance-sensitive membrane which is particularly suited for installation on a solid state sensor. Polyimide, dissolved in a solvent, such as N,N-dimethylformamide, or N-methyl-2-pyrrolidone (polyimide encapsulant), is combined with an ionophore, plasticizer, and a lipophilic additive. The ionophore may be a calcium ionophore, an ammonium ionophore, or any other ionophore. The membrane may also incorporate, or may be covered by, a bioactive agent, such as an enzyme, an immunochemical, bacteria, antibody, virus, or antigen. The plasticizer is one or both of dimethyl phthalate and diethylene glycol dibenzoate. The lipophilic additive may be potassium tetrakis(p-chlorophenyl)borate. The resulting substance-sensitive membrane has electrochemical properties which compare favorably to those of conventional PVC membranes, and exhibit significantly greater adhesion to glasses and semiconductor substrate materials. The improved adhesion may prolong the life of the sensors and prevent the formation of electrolyte shunts which have been known to render solid state sensors inoperative.

摘要翻译： 采用聚酰亚胺基体形成特别适用于固态传感器的物质敏感膜。 将溶解在溶剂如N，N-二甲基甲酰胺或N-甲基-2-吡咯烷酮（聚酰亚胺密封剂）中的聚酰亚胺与离子载体，增塑剂和亲脂性添加剂组合。 离子载体可以是钙离子载体，铵离子载体或任何其它离子载体。 膜还可以包含生物活性剂，例如酶，免疫化学，细菌，抗体，病毒或抗原，或可被其覆盖。 增塑剂是邻苯二甲酸二甲酯和二甘醇二苯甲酸酯中的一种或两种。 亲脂性添加剂可以是四（对氯苯基）硼酸钾。 所得到的物质敏感膜具有与常规PVC膜相当的电化学性能，并且对玻璃和半导体衬底材料表现出显着更大的粘合性。 改进的附着力可延长传感器的使用寿命，并防止已知使固态传感器不起作用的电解液分流器的形成。

公开(公告)号：US5102526A

公开(公告)日：1992-04-07

申请号：US517636

申请日：1990-05-02

申请人： Richard B. Brown ,  Geun-Sig Cha

发明人： Richard B. Brown ,  Geun-Sig Cha

IPC分类号： G01N27/327 ,  G01N27/333 ,  G01N27/414

CPC分类号： G01N27/333

摘要： A silicone matrix is employed to form a substance-sensitive membrane which is particularly suited for installation on a solid state sensor. The ionophore may be a potassium ionophore, an ammonium ionophore or any other ionophore. The membrane may be coupled to the molecule of interest through a bioactive agent, such as an enzyme, an immunochemical, bacteria, antibody, virus, or antigen. The resulting substance-sensitive membrane has electrochemical properties which compare favorably to those of conventional PVC membranes, and exhibit significantly greater adhesion to glasses and semiconductor substrate materials. The improved adhesion will prolong the life of the sensors and prevent the formation of electrolyte shunts which have been known to render solid state sensors inoperative.

摘要翻译： 使用有机硅基体形成特别适合于安装在固态传感器上的物质敏感膜。 离子载体可以是钾离子载体，铵离子载体或任何其它离子载体。 膜可以通过生物活性剂（例如酶，免疫化学，细菌，抗体，病毒或抗原）与感兴趣的分子偶联。 所得到的物质敏感膜具有与常规PVC膜相当的电化学性能，并且对玻璃和半导体衬底材料表现出显着更大的粘合性。 改善的粘合力将延长传感器的使用寿命，并防止已知使固态传感器不起作用的电解液分流器的形成。