公开(公告)号：US20130116211A1

公开(公告)日：2013-05-09

申请号：US13724663

申请日：2012-12-21

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Venkateswarlu Somepalli

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Venkateswarlu Somepalli

IPC分类号： A61K31/70 ,  A61K31/19 ,  C07J63/00 ,  A61K31/56

CPC分类号： C07J63/008

摘要： New salts or ion-pair complexes obtained by a reaction between boswellic acids or selectively enriched 3-O-acetyl-11-keto-β-boswellic acid (AKBA) or 11-keto-β-boswellic acid (KBA) compounds obtained through a new improved process, and an organic amine, more particularly with glucosamine. These salts or ion pair complexes are useful in nutraceuticals and in food supplements for anti-inflammatory and analgesic treatment of joints and cancer prevention or cancer therapeutic agents. These salts or ion pair complexes could also be used in cosmetic or pharmaceutical composition for external treatment of body parts or organs to treat inflammatory diseases or cancer.

摘要翻译： 通过硼酸或选择性富集的3-O-乙酰基-11-酮-β-保乳酸（AKBA）或11-酮-β-保乳酸（KBA）化合物之间的反应获得的新的盐或离子对络合物通过 新的改进方法，和有机胺，更特别是葡糖胺。 这些盐或离子对复合物可用于营养药物和用于消炎和止痛治疗关节和癌症预防或癌症治疗剂的食品添加剂中。 这些盐或离子对复合物也可以用于化妆品或药物组合物，用于身体部位或器官的外部治疗以治疗炎性疾病或癌症。

公开(公告)号：US07455860B2

公开(公告)日：2008-11-25

申请号：US11201416

申请日：2005-08-11

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti

IPC分类号： A61K36/00

CPC分类号： A61K36/324 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/12 ,  A61K31/726 ,  A61K36/76 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/308 ,  A23V2250/2112 ,  A23V2250/21 ,  A23V2250/2132

摘要： This invention relates to a dietary supplement which is a phytochemical composition. This composition is capable of controlling inflammatory conditions and preventing and curing cancer in mammals. The composition comprises a synergistic mixture of standardized Boswellia extract, salts of glucosamine, and curcuminoids optionally containing bromelain, chondroitin, methylsulphonylmethane, resveratrol, extracts of white Willow and ginger, and quercetin.

摘要翻译： 本发明涉及作为植物化学成分的膳食补充剂。 该组合物能够控制炎症状况并预防和治愈哺乳动物的癌症。 组合物包含标准化的乳香提取物，葡糖胺的盐和任选含有菠萝蛋白酶，软骨素，甲基磺酰甲烷，白藜芦醇，白柳和姜的提取物和槲皮素的姜黄素的协同混合物。

公开(公告)号：US08524769B2

公开(公告)日：2013-09-03

申请号：US10432058

申请日：2002-03-05

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Sridhar Pratha

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Sridhar Pratha

IPC分类号： A61K31/21

CPC分类号： C07J63/008

摘要： The invention relates to a process for producing a fraction enriched upto 100% of 3-O-acetyl-11-keto-β-boswellic acid. An organic solvent extract of gum resin from Boswellia species is first subjected to oxidation and then acetylation or vice versa. This converts the less potent boswellic acids present in the fraction to AKBA. This treated fraction is subjected to further purification and separation by chromatographic separation techniques to enhance its purity and to remove contaminants therefrom. This process provide an access to a fraction enriched in 10-100% AKBA for therapeutic applications.

摘要翻译： 本发明涉及一种生产高达100％的3-O-乙酰基-11-酮-β-乳糖酸的级分的方法。 首先将来自Boswellia物种的树胶的有机溶剂提取物进行氧化，然后进行乙酰化反应，反之亦然。 这将该部分中存在的较不有效的保乳酸转化为AKBA。 通过色谱分离技术对经处理的级分进行进一步纯化和分离，以提高其纯度并从中除去污染物。 该方法提供了获得用于治疗应用的富含10-100％AKBA的级分。

公开(公告)号：US07893263B2

公开(公告)日：2011-02-22

申请号：US10543387

申请日：2004-07-08

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Venkateswarlu Somepalli ,  Venkateswara Rao Chirravuri

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Venkateswarlu Somepalli ,  Venkateswara Rao Chirravuri

IPC分类号： C07C45/00 ,  C07C47/00 ,  C07C233/00 ,  C07C235/00 ,  C07D211/78 ,  C07D211/90 ,  C07D241/04 ,  C07D295/00

CPC分类号： C07J63/008 ,  C07C229/08 ,  C07C233/58 ,  C07C233/60 ,  C07C233/62 ,  C07C235/40 ,  C07C235/82 ,  C07C2603/52 ,  C07D213/80 ,  C07D313/06 ,  C07D327/10

摘要： This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are described herein. These compounds exhibit good hypoglycemic and 5-lipoxygenase inhibitory activities. They also inhibit tumour growth. Pharmaceutical compositions containing known adjutants and the title compounds are also within the scope of this invention.

摘要翻译： 本发明涉及式I的新型科罗索酸类似物，其中本文描述了R1，R2，R3，R4和R5。 这些化合物表现出良好的降血糖和5-脂氧合酶抑制活性。 它们也抑制肿瘤生长。 含有已知副产物和标题化合物的药物组合物也在本发明的范围内。

公开(公告)号：US20090042832A1

公开(公告)日：2009-02-12

申请号：US11817946

申请日：2005-03-07

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Venkateswarlu Somepalli

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Venkateswarlu Somepalli

IPC分类号： A61K31/715 ,  C07H3/00 ,  C07C59/82 ,  A61K31/19

CPC分类号： C07J63/008

摘要： New salts or ion pair complexes obtained by a reaction between boswellic acids or selectively enriched 3-O-acetyl-11-keto-β-boswellic acid (AKBA) or 11-keto-β-boswellic acid (KBA) compounds obtained through a new improved process, and an organic amine, more particularly with glucosamine. These salts or ion pair complexes are useful in nutraceuticals and in food supplements for anti-inflammatory and analgesic treatment of joints and cancer prevention or cancer therapeutic agents. These salts or ion pair complexes could also be used in cosmetic or pharmaceutical composition for external treatment of body parts or organs to treat inflammatory diseases or cancer.

摘要翻译： 通过一种新的获得的硼酸或选择性富集的3-O-乙酰基-11-酮-β-保乳酸（AKBA）或11-酮-β-保乳酸（KBA）化合物之间的反应获得的新的盐或离子对络合物 改进的方法，和有机胺，更特别是葡糖胺。 这些盐或离子对复合物可用于营养药物和用于消炎和止痛治疗关节和癌症预防或癌症治疗剂的食品添加剂中。 这些盐或离子对复合物也可以用于化妆品或药物组合物，用于身体部位或器官的外部治疗以治疗炎性疾病或癌症。

公开(公告)号：US08748598B2

公开(公告)日：2014-06-10

申请号：US13250841

申请日：2011-09-30

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Krishanu Sengupta

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Krishanu Sengupta

IPC分类号： C07D295/18 ,  C07D241/04 ,  C07C61/22 ,  C07C69/74 ,  C07D233/54

CPC分类号： C07J63/008

摘要： Analogs of 3-O-acetyl-11-keto-beta-boswellic acid and their method of preparation are presented. The analogs may be used as anti-inflammatory and anti-cancer agents. The compounds inhibit 5-lipoxygenase enzyme and various cell lines related to inflammation as well as to cancer showing a significantly better efficacy when compared to the normal boswellic acids. The analogs are capable of controlling and treating various inflammatory diseases and cancers.

摘要翻译： 提出了3-O-乙酰基-11-酮-β-乳糖酸的类似物及其制备方法。 类似物可以用作抗炎和抗癌剂。 该化合物抑制5-脂氧合酶和与炎症相关的各种细胞系以及与正常的保乳酸相比显示出显着更好的功效的癌症。 类似物能够控制和治疗各种炎性疾病和癌症。

公开(公告)号：US20120035176A1

公开(公告)日：2012-02-09

申请号：US13250841

申请日：2011-09-30

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Krishanu Sengupta

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti ,  Krishanu Sengupta

IPC分类号： A61K31/535 ,  A61K31/19 ,  C07D295/18 ,  C07D241/04 ,  A61K31/4965 ,  A61P35/02 ,  A61K31/4164 ,  A61P37/06 ,  A61P35/00 ,  A61P19/02 ,  A61P11/06 ,  A61P1/00 ,  C07C61/22 ,  C07D233/54

CPC分类号： C07J63/008

摘要： Analogs of 3-O-acetyl-11-keto-beta-boswellic acid and their method of preparation are presented. The analogs may be used as anti-inflammatory and anti-cancer agents. The compounds inhibit 5-lipoxygenase enzyme and various cell lines related to inflammation as well as to cancer showing a significantly better efficacy when compared to the normal boswellic acids. The analogs are capable of controlling and treating various inflammatory diseases and cancers.

摘要翻译： 提出了3-O-乙酰基-11-酮-β-乳糖酸的类似物及其制备方法。 类似物可以用作抗炎和抗癌剂。 该化合物抑制5-脂氧合酶和与炎症相关的各种细胞系以及与正常的保乳酸相比显示出显着更好的功效的癌症。 类似物能够控制和治疗各种炎性疾病和癌症。

公开(公告)号：US20090318551A1

公开(公告)日：2009-12-24

申请号：US12549663

申请日：2009-08-28

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti

IPC分类号： A61K31/215 ,  C07C61/29 ,  C07C69/757 ,  C07C255/47 ,  C07C69/78 ,  C07C229/02 ,  A61K31/19 ,  A61K31/235 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07J63/008

摘要： This invention relates to novel AKBA analogs of the formula I given below: Where in R1, R2, R3, R4 and R5 in each of the said analogs are: 1. R1═OCHO, R2═H, R3═COOH, R4 & R5═O 2. R1═OCOCH2Cl, R2═H, R3═COOH, R4 & R5═O 3. R1=5′-O-methylgalloyloxy, R2═H, R3═COOH, R4 & R5═O 4. R1═OCOCH2CH2COOH, R2═H, R3═COOH, R4 & R5═O 5. R1=8′,9′-Dihydro-4′-hydroxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 6. R1=4′-Hydroxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 7. R1=3′,4′-Dimethoxycinnamoyloxy, R2═H, R3═COOH, R4 & R5′O 8. R1=3′,4′-Dihydroxy-5′-methoxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 9. R1═OCOCH2NH(tert-BOC), R2═H, R3═COOCH3, R4 & R5═O 10. R1═OCOCH2NH2HCl, R2═H, R3═COOH, R4 & R5═O 11. R1═OCOCH(CH3)NH2HCl, R2═H, R3═COOH, R4 & R5═O 12. R1═H, R2═OH, R3═COOCH3, R4 & R5═O 13. R1═H, R2═Br, R3═COOCH3, R4 & R5═O 14. R1═CN, R2═H, R3═COOCH3, R4 & R5═O 15. R1═SH, R2═H, R3═COOCH3, R4 & R5═O 16. R1 & R2═N(OH), R3═COOCH3, R4 & R5═O 17. R1 & R2═H & OCOCH3 R3═H, R4 & R5═O 18. R1═OCOCH3, R2═H, R3═COOCH2CH2N(CH3)2, R4 & R5═O 19. R1═OCOCH3, R2═H R3═CONH2, R4 & R5═O 20. R1═OCOCH3, R2═H, R3═CONHNH2, R4 & R550 O 21. R1═OCOCH3, R2═H, R3═CONHCH2CH2NH2, R4 & R5═O 22. R1═OCOCH3, R2═H, R3═CONHCH2CH2OH, R4 & R5═O 23. R1═OCOCH3, R2═H, R3═CON(CH2CH2)2NH, R4 & R5═O 24. R1═OCOCH3, R2═H R3═NCO, R4 & R5═O 25. R1═OCOCH3, R2═H R3═NH2, R4 & R5═O 26. R1═OCOCH3, R2═H R3═CN, R4 & R5═O 27. R1═OH, R2═H R3═COOH, R4 & R5═OH & H These compounds exhibited 5-Lipoxigenase inhibitory properties and these compounds may be used in pharmaceutical compositions for therapeutic applications against a variety of inflammations and hypersensitivity-based human diseases including asthma, arthritis, bowel diseases such as ulcerative colitis and circulatory disorders such as shock and ischaemia. These compounds also inhibited the growth of Brine Shrimp in cultures, which may be considered as a positive indication for cytotoxicity and antitumor activity.

公开(公告)号：US07625947B2

公开(公告)日：2009-12-01

申请号：US10540257

申请日：2004-06-18

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Subbaraju Gottumukkala ,  Trimurtulu Golakoti

IPC分类号： A61K31/21 ,  A61K31/015 ,  C07C69/74

CPC分类号： C07J63/008

摘要： This invention relates to novel AKBA analogs of the formula I given below: Where in R1, R2, R3, R4 and R5 in each of the said analogs are: 1. R1═OCHO, R2═H, R3═COOH, R4 & R5═O 2. R1═OCOCH2Cl, R2═H, R3═COOH, R4 & R5═O 3. R1═5′-O-methylgalloyloxy, R2═H, R3═COOH, R4 & R5═O 4. R1═OCOCH2CH2COOH, R2═H, R3═COOH, R4 & R5═O 5. R1═8′,9′-Dihydro-4′-hydroxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 6. R1═4′-Hydroxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 7. R1═3′,4′-Dimethoxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 8. R1═3′,4′-Dihydroxy-5′-methoxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 9. R1═OCOCH2NH(tert-BOC), R2═H, R3═COOCH3, R4 & R5═O 10. R1═OCOCH2NH2HCl, R2═H, R3—COOH, R4 & R5═O 11. R1═OCOCH(CH3)NH2HCl, R2═H, R3═COOH, R4 & R5═O 12. R1═H, R2═OH, R3═COOCH3, R4 & R5═O 13. R1═H, R2═Br, R3 COOCH3, R4 & R5═O 14. R1═CN, R2═H, R3═COOCH3, R4 & R5═O 15. R1═SH, R2═H, R3═COOCH3, R4& R5═O 16. R1 & R2═N(OH), R3═COOCH3, R4 & R5═O 17. R1 & R2═H & OCOCH3 R3═H, R4 & R5═O 18. R1═OCOCH3, R2═H R3═COOCH2CH2N(CH3)2, R4 & R5═O 19. R1═OCOCH3, R2═H R3═CONH2, R4 & R5═O 20. R1═OCOCH3, R2═H, R3═CONHNH2, R4 & R5═O 21. R1═OCOCH3, R2═H, R3═CONHCH2CH2NH2, R4 & R5═O 22. R1═OCOCH3, R2═H, R3═CONHCH2CH2OH, R4 & R5═O 23. R1═OCOCH3, R2═H, R3═CON(CH2CH2)2NH, R4 & R5═O 24. R1═OCOCH3, R2═H R3═NCO, R4 & R5═O 25. R1═OCOCH3, R2═H R3═NH2, R4 & R5═O 26. R1═OCOCH3, R2═H R3═CN, R4 & R5═O 27. R1═OH, R2═H R3═COOH, R4 & R5═OH & H These compounds exhibited 5-Lipoxigenase inhibitory properties and these compounds may be used in pharmaceutical compositions for therapeutic applications against a variety of inflammations and hypersensitivity-based human diseases including asthma, arthritis, bowel diseases such as ulcerative colitis and circulatory disorders such as shock and ischaemia. These compounds also inhibited the growth of Brine Shrimp in cultures, which may be considered as a positive indication for cytotoxicity and antitumor activity.

公开(公告)号：US09345732B2

公开(公告)日：2016-05-24

申请号：US13510815

申请日：2009-11-19

申请人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkateswara Rao Chirravuri ,  Sivaramakrishna Chillara

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkateswara Rao Chirravuri ,  Sivaramakrishna Chillara

IPC分类号： A61K36/185 ,  A61K36/67 ,  A61K36/16 ,  A61K36/58 ,  A23L1/30

CPC分类号： A61K36/185 ,  A23L33/105 ,  A61K2300/00

摘要： The invention discloses phytochemical agents derived from Holoptelea integrifolia and novel composition(s) comprising at least one component selected from the extract(s), fraction(s) and active compound(s) for the protection and alleviation of Metabolic Syndrome, insulin resistance, endothelial dysfunction, chronic kidney disease, atherosclerosis, diabetes and other disease conditions associated with metabolic syndrome. The invention also discloses the amelioration of certain biomarker molecules such as Peroxisome proliferator-activated receptor gamma (PPAR-γ), Adipose Differentiation Related Protein (ADRP), CD36, Adipocyte Fatty-acid-Binding Protein (aP2/FABP-4/A-FABP), beta-3 Adrenergic Receptor (β3AR), Leptin, Perilipin and Adiponectin by using the phytochemical components derived from Holoptelea integrifolia.

摘要翻译： 本发明公开了源自全息莲的植物化学试剂和包含至少一种选自提取物，级分和活性化合物的组分的新组合物，用于保护和减轻代谢综合征，胰岛素抵抗， 内皮功能障碍，慢性肾脏疾病，动脉粥样硬化，糖尿病等与代谢综合征相关的疾病。 本发明还公开了一些生物标记分子的改进，例如过氧化物酶体增殖物激活受体γ（PPAR-γ），脂肪分化相关蛋白（ADRP），CD36，脂肪细胞脂肪酸结合蛋白（aP2 / FABP-4 / A- FABP），β-3肾上腺素能受体（＆bgr; 3AR），瘦蛋白，Perilipin和脂连蛋白，通过使用源自全息莲的植物化学成分。