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公开(公告)号：US08748598B2
公开(公告)日：2014-06-10
申请号：US13250841
申请日：2011-09-30
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Krishanu Sengupta
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Krishanu Sengupta
IPC分类号： C07D295/18 , C07D241/04 , C07C61/22 , C07C69/74 , C07D233/54
CPC分类号： C07J63/008
摘要： Analogs of 3-O-acetyl-11-keto-beta-boswellic acid and their method of preparation are presented. The analogs may be used as anti-inflammatory and anti-cancer agents. The compounds inhibit 5-lipoxygenase enzyme and various cell lines related to inflammation as well as to cancer showing a significantly better efficacy when compared to the normal boswellic acids. The analogs are capable of controlling and treating various inflammatory diseases and cancers.
摘要翻译： 提出了3-O-乙酰基-11-酮-β-乳糖酸的类似物及其制备方法。 类似物可以用作抗炎和抗癌剂。 该化合物抑制5-脂氧合酶和与炎症相关的各种细胞系以及与正常的保乳酸相比显示出显着更好的功效的癌症。 类似物能够控制和治疗各种炎性疾病和癌症。
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公开(公告)号：US20120035176A1
公开(公告)日：2012-02-09
申请号：US13250841
申请日：2011-09-30
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Krishanu Sengupta
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Krishanu Sengupta
IPC分类号： A61K31/535 , A61K31/19 , C07D295/18 , C07D241/04 , A61K31/4965 , A61P35/02 , A61K31/4164 , A61P37/06 , A61P35/00 , A61P19/02 , A61P11/06 , A61P1/00 , C07C61/22 , C07D233/54
CPC分类号： C07J63/008
摘要： Analogs of 3-O-acetyl-11-keto-beta-boswellic acid and their method of preparation are presented. The analogs may be used as anti-inflammatory and anti-cancer agents. The compounds inhibit 5-lipoxygenase enzyme and various cell lines related to inflammation as well as to cancer showing a significantly better efficacy when compared to the normal boswellic acids. The analogs are capable of controlling and treating various inflammatory diseases and cancers.
摘要翻译： 提出了3-O-乙酰基-11-酮-β-乳糖酸的类似物及其制备方法。 类似物可以用作抗炎和抗癌剂。 该化合物抑制5-脂氧合酶和与炎症相关的各种细胞系以及与正常的保乳酸相比显示出显着更好的功效的癌症。 类似物能够控制和治疗各种炎性疾病和癌症。
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3.发明申请Novel Salts Of Boswellic Acids And Selectively Enriched Boswellic Acids And Processes For The Same 审中-公开新型磺草酸和选择性富含乳香酸和过程的盐公开(公告)号：US20130116211A1
公开(公告)日：2013-05-09
申请号：US13724663
申请日：2012-12-21
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli
CPC分类号： C07J63/008
摘要： New salts or ion-pair complexes obtained by a reaction between boswellic acids or selectively enriched 3-O-acetyl-11-keto-β-boswellic acid (AKBA) or 11-keto-β-boswellic acid (KBA) compounds obtained through a new improved process, and an organic amine, more particularly with glucosamine. These salts or ion pair complexes are useful in nutraceuticals and in food supplements for anti-inflammatory and analgesic treatment of joints and cancer prevention or cancer therapeutic agents. These salts or ion pair complexes could also be used in cosmetic or pharmaceutical composition for external treatment of body parts or organs to treat inflammatory diseases or cancer.
摘要翻译： 通过硼酸或选择性富集的3-O-乙酰基-11-酮-β-保乳酸（AKBA）或11-酮-β-保乳酸（KBA）化合物之间的反应获得的新的盐或离子对络合物通过 新的改进方法，和有机胺，更特别是葡糖胺。 这些盐或离子对复合物可用于营养药物和用于消炎和止痛治疗关节和癌症预防或癌症治疗剂的食品添加剂中。 这些盐或离子对复合物也可以用于化妆品或药物组合物，用于身体部位或器官的外部治疗以治疗炎性疾病或癌症。
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公开(公告)号：US07455860B2
公开(公告)日：2008-11-25
申请号：US11201416
申请日：2005-08-11
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti
IPC分类号： A61K36/00
CPC分类号： A61K36/324 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/12 , A61K31/726 , A61K36/76 , A61K45/06 , A61K2300/00 , A23V2250/308 , A23V2250/2112 , A23V2250/21 , A23V2250/2132
摘要： This invention relates to a dietary supplement which is a phytochemical composition. This composition is capable of controlling inflammatory conditions and preventing and curing cancer in mammals. The composition comprises a synergistic mixture of standardized Boswellia extract, salts of glucosamine, and curcuminoids optionally containing bromelain, chondroitin, methylsulphonylmethane, resveratrol, extracts of white Willow and ginger, and quercetin.
摘要翻译： 本发明涉及作为植物化学成分的膳食补充剂。 该组合物能够控制炎症状况并预防和治愈哺乳动物的癌症。 组合物包含标准化的乳香提取物，葡糖胺的盐和任选含有菠萝蛋白酶，软骨素，甲基磺酰甲烷，白藜芦醇，白柳和姜的提取物和槲皮素的姜黄素的协同混合物。
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5.发明授权Process for producing a fraction enriched up to 100% of 3-O-acetyl-11-keto-beta-boswellic acid from an extract containing a mixture of boswellic acids 有权从含有乳糖酸的混合物的提取物中生产富含高达100％的3-O-乙酰基-11-酮-β-保乳酸的级分的方法公开(公告)号：US08524769B2
公开(公告)日：2013-09-03
申请号：US10432058
申请日：2002-03-05
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Sridhar Pratha
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Sridhar Pratha
IPC分类号： A61K31/21
CPC分类号： C07J63/008
摘要： The invention relates to a process for producing a fraction enriched upto 100% of 3-O-acetyl-11-keto-β-boswellic acid. An organic solvent extract of gum resin from Boswellia species is first subjected to oxidation and then acetylation or vice versa. This converts the less potent boswellic acids present in the fraction to AKBA. This treated fraction is subjected to further purification and separation by chromatographic separation techniques to enhance its purity and to remove contaminants therefrom. This process provide an access to a fraction enriched in 10-100% AKBA for therapeutic applications.
摘要翻译： 本发明涉及一种生产高达100％的3-O-乙酰基-11-酮-β-乳糖酸的级分的方法。 首先将来自Boswellia物种的树胶的有机溶剂提取物进行氧化，然后进行乙酰化反应，反之亦然。 这将该部分中存在的较不有效的保乳酸转化为AKBA。 通过色谱分离技术对经处理的级分进行进一步纯化和分离，以提高其纯度并从中除去污染物。 该方法提供了获得用于治疗应用的富含10-100％AKBA的级分。
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6.发明授权Structural analogs of corosolic acid having anti-diabetic and anti-inflammatory properties 有权具有抗糖尿病和抗炎特性的科罗索酸的结构类似物公开(公告)号：US07893263B2
公开(公告)日：2011-02-22
申请号：US10543387
申请日：2004-07-08
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli , Venkateswara Rao Chirravuri
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli , Venkateswara Rao Chirravuri
IPC分类号： C07C45/00 , C07C47/00 , C07C233/00 , C07C235/00 , C07D211/78 , C07D211/90 , C07D241/04 , C07D295/00
CPC分类号： C07J63/008 , C07C229/08 , C07C233/58 , C07C233/60 , C07C233/62 , C07C235/40 , C07C235/82 , C07C2603/52 , C07D213/80 , C07D313/06 , C07D327/10
摘要： This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are described herein. These compounds exhibit good hypoglycemic and 5-lipoxygenase inhibitory activities. They also inhibit tumour growth. Pharmaceutical compositions containing known adjutants and the title compounds are also within the scope of this invention.
摘要翻译： 本发明涉及式I的新型科罗索酸类似物，其中本文描述了R1，R2，R3，R4和R5。 这些化合物表现出良好的降血糖和5-脂氧合酶抑制活性。 它们也抑制肿瘤生长。 含有已知副产物和标题化合物的药物组合物也在本发明的范围内。
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7.发明申请NOVEL SALTS OF BOSWELLIC ACIDS AND SELECTIVELY ENRICHED BOSWELLIC ACIDS AND PROCESSES FOR THE SAME 审中-公开硼酸盐和选择性硼酸盐的新型盐及其相容方法公开(公告)号：US20090042832A1
公开(公告)日：2009-02-12
申请号：US11817946
申请日：2005-03-07
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Venkateswarlu Somepalli
IPC分类号： A61K31/715 , C07H3/00 , C07C59/82 , A61K31/19
CPC分类号： C07J63/008
摘要： New salts or ion pair complexes obtained by a reaction between boswellic acids or selectively enriched 3-O-acetyl-11-keto-β-boswellic acid (AKBA) or 11-keto-β-boswellic acid (KBA) compounds obtained through a new improved process, and an organic amine, more particularly with glucosamine. These salts or ion pair complexes are useful in nutraceuticals and in food supplements for anti-inflammatory and analgesic treatment of joints and cancer prevention or cancer therapeutic agents. These salts or ion pair complexes could also be used in cosmetic or pharmaceutical composition for external treatment of body parts or organs to treat inflammatory diseases or cancer.
摘要翻译： 通过一种新的获得的硼酸或选择性富集的3-O-乙酰基-11-酮-β-保乳酸（AKBA）或11-酮-β-保乳酸（KBA）化合物之间的反应获得的新的盐或离子对络合物 改进的方法，和有机胺，更特别是葡糖胺。 这些盐或离子对复合物可用于营养药物和用于消炎和止痛治疗关节和癌症预防或癌症治疗剂的食品添加剂中。 这些盐或离子对复合物也可以用于化妆品或药物组合物，用于身体部位或器官的外部治疗以治疗炎性疾病或癌症。
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公开(公告)号：US20090318551A1
公开(公告)日：2009-12-24
申请号：US12549663
申请日：2009-08-28
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti
IPC分类号： A61K31/215 , C07C61/29 , C07C69/757 , C07C255/47 , C07C69/78 , C07C229/02 , A61K31/19 , A61K31/235 , A61P35/00 , A61P29/00
CPC分类号： C07J63/008
摘要： This invention relates to novel AKBA analogs of the formula I given below: Where in R1, R2, R3, R4 and R5 in each of the said analogs are: 1. R1═OCHO, R2═H, R3═COOH, R4 & R5═O 2. R1═OCOCH2Cl, R2═H, R3═COOH, R4 & R5═O 3. R1=5′-O-methylgalloyloxy, R2═H, R3═COOH, R4 & R5═O 4. R1═OCOCH2CH2COOH, R2═H, R3═COOH, R4 & R5═O 5. R1=8′,9′-Dihydro-4′-hydroxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 6. R1=4′-Hydroxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 7. R1=3′,4′-Dimethoxycinnamoyloxy, R2═H, R3═COOH, R4 & R5′O 8. R1=3′,4′-Dihydroxy-5′-methoxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 9. R1═OCOCH2NH(tert-BOC), R2═H, R3═COOCH3, R4 & R5═O 10. R1═OCOCH2NH2HCl, R2═H, R3═COOH, R4 & R5═O 11. R1═OCOCH(CH3)NH2HCl, R2═H, R3═COOH, R4 & R5═O 12. R1═H, R2═OH, R3═COOCH3, R4 & R5═O 13. R1═H, R2═Br, R3═COOCH3, R4 & R5═O 14. R1═CN, R2═H, R3═COOCH3, R4 & R5═O 15. R1═SH, R2═H, R3═COOCH3, R4 & R5═O 16. R1 & R2═N(OH), R3═COOCH3, R4 & R5═O 17. R1 & R2═H & OCOCH3 R3═H, R4 & R5═O 18. R1═OCOCH3, R2═H, R3═COOCH2CH2N(CH3)2, R4 & R5═O 19. R1═OCOCH3, R2═H R3═CONH2, R4 & R5═O 20. R1═OCOCH3, R2═H, R3═CONHNH2, R4 & R550 O 21. R1═OCOCH3, R2═H, R3═CONHCH2CH2NH2, R4 & R5═O 22. R1═OCOCH3, R2═H, R3═CONHCH2CH2OH, R4 & R5═O 23. R1═OCOCH3, R2═H, R3═CON(CH2CH2)2NH, R4 & R5═O 24. R1═OCOCH3, R2═H R3═NCO, R4 & R5═O 25. R1═OCOCH3, R2═H R3═NH2, R4 & R5═O 26. R1═OCOCH3, R2═H R3═CN, R4 & R5═O 27. R1═OH, R2═H R3═COOH, R4 & R5═OH & H These compounds exhibited 5-Lipoxigenase inhibitory properties and these compounds may be used in pharmaceutical compositions for therapeutic applications against a variety of inflammations and hypersensitivity-based human diseases including asthma, arthritis, bowel diseases such as ulcerative colitis and circulatory disorders such as shock and ischaemia. These compounds also inhibited the growth of Brine Shrimp in cultures, which may be considered as a positive indication for cytotoxicity and antitumor activity.
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公开(公告)号：US07625947B2
公开(公告)日：2009-12-01
申请号：US10540257
申请日：2004-06-18
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti
IPC分类号： A61K31/21 , A61K31/015 , C07C69/74
CPC分类号： C07J63/008
摘要： This invention relates to novel AKBA analogs of the formula I given below: Where in R1, R2, R3, R4 and R5 in each of the said analogs are: 1. R1═OCHO, R2═H, R3═COOH, R4 & R5═O 2. R1═OCOCH2Cl, R2═H, R3═COOH, R4 & R5═O 3. R1═5′-O-methylgalloyloxy, R2═H, R3═COOH, R4 & R5═O 4. R1═OCOCH2CH2COOH, R2═H, R3═COOH, R4 & R5═O 5. R1═8′,9′-Dihydro-4′-hydroxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 6. R1═4′-Hydroxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 7. R1═3′,4′-Dimethoxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 8. R1═3′,4′-Dihydroxy-5′-methoxycinnamoyloxy, R2═H, R3═COOH, R4 & R5═O 9. R1═OCOCH2NH(tert-BOC), R2═H, R3═COOCH3, R4 & R5═O 10. R1═OCOCH2NH2HCl, R2═H, R3—COOH, R4 & R5═O 11. R1═OCOCH(CH3)NH2HCl, R2═H, R3═COOH, R4 & R5═O 12. R1═H, R2═OH, R3═COOCH3, R4 & R5═O 13. R1═H, R2═Br, R3 COOCH3, R4 & R5═O 14. R1═CN, R2═H, R3═COOCH3, R4 & R5═O 15. R1═SH, R2═H, R3═COOCH3, R4& R5═O 16. R1 & R2═N(OH), R3═COOCH3, R4 & R5═O 17. R1 & R2═H & OCOCH3 R3═H, R4 & R5═O 18. R1═OCOCH3, R2═H R3═COOCH2CH2N(CH3)2, R4 & R5═O 19. R1═OCOCH3, R2═H R3═CONH2, R4 & R5═O 20. R1═OCOCH3, R2═H, R3═CONHNH2, R4 & R5═O 21. R1═OCOCH3, R2═H, R3═CONHCH2CH2NH2, R4 & R5═O 22. R1═OCOCH3, R2═H, R3═CONHCH2CH2OH, R4 & R5═O 23. R1═OCOCH3, R2═H, R3═CON(CH2CH2)2NH, R4 & R5═O 24. R1═OCOCH3, R2═H R3═NCO, R4 & R5═O 25. R1═OCOCH3, R2═H R3═NH2, R4 & R5═O 26. R1═OCOCH3, R2═H R3═CN, R4 & R5═O 27. R1═OH, R2═H R3═COOH, R4 & R5═OH & H These compounds exhibited 5-Lipoxigenase inhibitory properties and these compounds may be used in pharmaceutical compositions for therapeutic applications against a variety of inflammations and hypersensitivity-based human diseases including asthma, arthritis, bowel diseases such as ulcerative colitis and circulatory disorders such as shock and ischaemia. These compounds also inhibited the growth of Brine Shrimp in cultures, which may be considered as a positive indication for cytotoxicity and antitumor activity.
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10.发明授权Agents from Ficus hispida for the amelioration of metabolic syndrome and related diseases 有权来自榕属的代谢物，用于改善代谢综合征及相关疾病公开(公告)号：US08703215B2
公开(公告)日：2014-04-22
申请号：US13364717
申请日：2012-02-02
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Kanaka Ranga Raju Gokaraju , Trimurtulu Golakoti , Krishanu Sengupta , Kiran Bhupathiraju
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Kanaka Ranga Raju Gokaraju , Trimurtulu Golakoti , Krishanu Sengupta , Kiran Bhupathiraju
IPC分类号： A61K36/00
CPC分类号： A61K36/60
摘要： The invention discloses herbal ingredient(s) derived from Ficus hispida comprising herb powder(s), extract(s), fraction(s), pure compound(s) or mixtures thereof and their compositions for alleviating metabolic disorders selected from metabolic syndrome, obesity, diabetes, atherosclerosis, endothelial dysfunction and other metabolic disorders or conditions; the for amelioration of different biological marker proteins and metabolic processes associated metabolic disorders.
摘要翻译： 本发明公开了衍生自包含草药粉末，提取物，级分，纯化合物或其混合物的榕属植物的草药成分及其用于减轻选自代谢综合征，肥胖症的代谢紊乱的组合物 ，糖尿病，动脉粥样硬化，内皮功能障碍等代谢紊乱或病症; 用于改善不同生物标记蛋白和与代谢紊乱相关的代谢过程。
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