公开(公告)号：US20060128965A1

公开(公告)日：2006-06-15

申请号：US11352805

申请日：2006-02-13

申请人： Gary Annis ,  George Lahm ,  Thomas Selby ,  Thomas Stevenson

发明人： Gary Annis ,  George Lahm ,  Thomas Selby ,  Thomas Stevenson

IPC分类号： C07D403/04 ,  C07F7/02 ,  C07D231/32

CPC分类号： C07D213/77 ,  A01N43/56 ,  C07C251/76 ,  C07C255/66 ,  C07D231/08 ,  C07D231/14 ,  C07D231/16 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14

摘要： This invention provides compounds of Formula I, methods for their preparation and use for preparing compounds of Formula II wherein R1, R2, R3, R5, R6, X and n are as defined in the disclosure. This invention also discloses preparation of compounds of Formula III wherein R1, R2, R7, R8, R9 and n are as defined in the disclosure. This invention also pertains to certain compounds of Formula 4 and 6 used to prepare compounds of Formula I. wherein R1, R2, R5, X and n are as defined in the disclosure.

摘要翻译： 本发明提供式I的化合物，其制备方法和用于制备式II化合物的方法，其中R 1，R 2，R 3， R 5，R 6，X和n如本公开所定义。 本发明还公开了式III化合物的制备，其中R 1，R 2，R 7，R 8， R 9和n如本公开所定义。 本发明还涉及用于制备式I化合物的某些式4和6化合物，其中R 1，R 2，R 5， ，X和n如本公开中所定义。

公开(公告)号：US20060205748A1

公开(公告)日：2006-09-14

申请号：US11158200

申请日：2005-06-21

申请人： Gary Annis ,  Bruce Finkelstein

发明人： Gary Annis ,  Bruce Finkelstein

IPC分类号： A01N43/54 ,  C07D49/02 ,  A01N43/56

CPC分类号： C07D213/81 ,  A01N43/10 ,  A01N43/40 ,  A01N43/54 ,  A01N43/80 ,  C07D213/82 ,  C07D231/40 ,  C07D333/38

摘要： This invention provides compounds of Formula (I), N-oxides and suitable salts thereof, wherein A and B are independently O or S; each J is independently a phenyl ring, a naphthyl ring system, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system wherein each ring or ring system is optionally substituted with 1 to 4 R5; K is, together with the two contiguous linking carbon atoms, a 5- or 6-membered heteroaromatic ring optionally substituted with 1 to 3 R4; and R1 R2, R3, R4, R5 and n are as defined in the disclosure. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents.

摘要翻译： 本发明提供式（I）的化合物，其N-氧化物及其合适的盐，其中A和B独立地为O或S; 每个J独立地是苯基环，萘基环系，5或6元杂芳环或芳族8-，9-或10-元稠合杂双环系统，其中每个环或环系统任选被1至 4 R 5; K与两个相邻的连接碳原子连在一起，任选被1至3个R 4取代的5或6元杂芳环; 和R 1，R 2，R 3，R 4，R 5和R 5， n如本公开中所定义。 还公开了用于控制无脊椎害虫的方法，包括使无脊椎害虫或其环境与生物有效量的式（I）化合物，其N-氧化物或该化合物的合适盐（例如，作为所述的组合物）接触 这里）。 本发明还涉及用于控制无脊椎害虫的组合物，其包含生物有效量的式（I）化合物，其N-氧化物或该化合物的合适的盐和至少一种选自以下的另外的组分： 表面活性剂，固体稀释剂和液体稀释剂。

公开(公告)号：US20080108821A1

公开(公告)日：2008-05-08

申请号：US12004902

申请日：2007-12-21

申请人： Gary Annis

发明人： Gary Annis

IPC分类号： C07D231/06 ,  C07D401/04

CPC分类号： C07D231/08 ,  C07D231/06 ,  C07D401/04

摘要： This invention relates to a method for preparing a 3-halo-4,5-dihydro-1H-pyrazole compound of Formula I comprising contacting with HX1 a different 4,5-dihydro-1H-pyrazole compound of Formula II wherein X1 is halogen and L, R, k and X2 are as defined in the disclosure. This invention also discloses preparation of compounds of Formula III wherein X1, R3, R6, R7, R8a, R8b and n are as defined in the disclosure.

摘要翻译： 本发明涉及制备式I的3-卤代-4,5-二氢-1H-吡唑化合物的方法，包括与HX 1不同的4,5-二氢-1H-吡唑化合物 其中X 1是卤素且L，R，k和X 2如本公开所定义。 本发明还公开了式III化合物的制备，其中X 1，R 3，R 6，R 7， R 8a，R 8b和n如本公开所定义。

公开(公告)号：US20070021468A1

公开(公告)日：2007-01-25

申请号：US10546165

申请日：2004-03-25

申请人： Gary Annis

发明人： Gary Annis

IPC分类号： A61K31/4439 ,  A61K31/4152 ,  C07D231/18 ,  C07D403/04

CPC分类号： C07D231/06 ,  C07D409/04

摘要： A method is disclosed for preparing a 2-substituted-5-oxo-3-pyrazolidinecarboxylate compound of Formula I. The method comprises contacting a succinic acid derivative of the formula R1OC(O)C(H)(X)C(R2a)(R2b)C(O)Y (i.e. Formula II) wherein X and Y are leaving groups and L, R1, R2a and R2b are as defined in the disclosure, with a substituted hydrazine of the formula LNHNH2 (i.e. Formula III) in the presence of a suitable acid scavenger and solvent. Also disclosed is the preparation of compounds of Formula IV wherein X1, R6, R7, R8a, R8b, R9, and n are as defined in the disclosure. Also disclosed is a composition comprising on a weight basis about 20 to 99% of the compound of Formula II wherein R1, R2a, R2b, R3, R4 and R5 are as defined in the disclosure; X is Cl, Br or I; and Y is F, Cl, Br or I; provided that when R2a and R2b are each H, and X and Y are each Cl then R1 is other than benzyl and when R2a and R2b are each phenyl, and X and Y are each Cl, then R1 is other than methyl or ethyl. Also disclosed is a crystalline composition comprising at least about 90% by weight of the compound of the formula R1OC(O)C(H)(X)C(R2a)(R2b)CO2H (i.e. Formula VI) wherein R2a and R2b are H, X is Br and R1 is methyl.

公开(公告)号：US20050215798A1

公开(公告)日：2005-09-29

申请号：US10518325

申请日：2003-07-29

申请人： Gary Annis

发明人： Gary Annis

IPC分类号： C07D231/06 ,  C07D231/08 ,  C07D401/04

CPC分类号： C07D231/08 ,  C07D231/06 ,  C07D401/04

摘要： This invention relates to a method for preparing 3-halo-4,5-dihydro-1H-pyrazole compound of Formula (I), comprising contacting with HX1 a different 4,5-dihydro-1H-pyrazole compound of Formula (II), wherein X1 is halogen and L, R, k and X2 are as defined in the disclosure. This invention also discloses preparation of compounds of Formula (III) wherein X1, R3, R6, R7, R8a, R8b, and n are as defined in the disclosure.

摘要翻译： 本发明涉及制备式（I）的3-卤代-4,5-二氢-1H-吡唑化合物的方法，包括与HX 1不同的4,5-二氢-1H- （II）的吡唑化合物，其中X 1是卤素，L，R 1，k和X 2如本公开所定义。 本发明还公开了制备式（III）的化合物，其中X 1，R 3，R 6，R 7， R 8，R 8b，R 8b和n如本公开所定义。