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    Benzodiazepinone compounds and methods of treatment using same
    1.
    发明授权
    Benzodiazepinone compounds and methods of treatment using same 有权
    苯并二氮杂酮化合物及其使用方法

    公开(公告)号：US08673897B2

    公开(公告)日：2014-03-18

    申请号：US13395566

    申请日：2010-09-17

    申请人： Gary D. Glick ,  Alexander Ross Hurd ,  Chad Alan Van Huis

    发明人： Gary D. Glick ,  Alexander Ross Hurd ,  Chad Alan Van Huis

    IPC分类号： C07D243/18 ,  C07D243/12 ,  A61K31/55

    CPC分类号： C07D403/04 ,  C07D243/24 ,  C07D243/26

    摘要： The invention provides 1,4-benzodiazepinone compounds, pharmaceutical compositions, and methods of treating autoimmune disorders, chronic inflammatory disorders, and hyperproliferative disorders. For example, the 1,4-benzodiazepinone compounds and pharmaceutical compositions are contemplated to be useful for treating rheumatoid arthritis, graft-versus-host disease, inflammatory bowel disease, and the like.

    摘要翻译： 本发明提供1,4-苯并二氮杂酮化合物，药物组合物和治疗自身免疫疾病，慢性炎症性疾病和过度增殖性疾病的方法。 例如，1,4-苯并二氮杂酮化合物和药物组合物被认为可用于治疗类风湿性关节炎，移植物抗宿主病，炎症性肠病等。

    COMPOSITIONS AND METHODS FOR INHIBITING THE PROLIFERATION OF CELLS
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR INHIBITING THE PROLIFERATION OF CELLS 有权
    抑制细胞增殖的组合物和方法

    公开(公告)号：US20130190300A1

    公开(公告)日：2013-07-25

    申请号：US13717096

    申请日：2012-12-17

    申请人： Gary D. Glick ,  Anthony W. Opipari

    发明人： Gary D. Glick ,  Anthony W. Opipari

    IPC分类号： C07D243/24

    CPC分类号： C07D243/24 ,  A61K31/551 ,  A61K31/5513 ,  C07D243/14 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

    摘要： The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.

    摘要翻译： 本发明涉及化合物，其发现方法及其治疗用途。 特别地，本发明提供了苯并二氮杂衍生物和使用苯并二氮杂衍生物作为治疗剂治疗与程序性细胞死亡，自身免疫，炎症和过度增殖等过程的错误调节相关的多种病症的方法。

    Compositions and methods for inhibiting the proliferation of cells
    8.
    发明授权
    Compositions and methods for inhibiting the proliferation of cells 有权
    抑制细胞增殖的组合物和方法

    公开(公告)号：US08415343B2

    公开(公告)日：2013-04-09

    申请号：US11643614

    申请日：2006-12-21

    申请人： Gary D. Glick ,  Anthony W. Opipari

    发明人： Gary D. Glick ,  Anthony W. Opipari

    IPC分类号： A61K31/55 ,  A61K31/59 ,  A61K31/05

    CPC分类号： C07D243/24 ,  A61K31/551 ,  A61K31/5513 ,  C07D243/14 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

    摘要： The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.

    摘要翻译： 本发明涉及化合物，其发现方法及其治疗用途。 特别地，本发明提供了苯并二氮杂衍生物和使用苯并二氮杂衍生物作为治疗剂治疗与程序性细胞死亡，自身免疫，炎症和过度增殖等过程的错误调节相关的多种病症的方法。

    NOVEL 1,4-BENZODIAZEPINE-2,5-DIONES WITH THERAPEUTIC PROPERTIES
    9.
    发明申请
    NOVEL 1,4-BENZODIAZEPINE-2,5-DIONES WITH THERAPEUTIC PROPERTIES 审中-公开
    具有治疗性质的新型1,4-苯并二氮杂环庚烷-2,5-二酮

    公开(公告)号：US20120088757A1

    公开(公告)日：2012-04-12

    申请号：US13309233

    申请日：2011-12-01

    申请人： Gary D. Glick

    发明人： Gary D. Glick

    IPC分类号： A61K31/5513 ,  A61P35/00 ,  A61P37/06 ,  C07D243/24 ,  C12N5/09

    CPC分类号： C07D243/14 ,  A61K31/5513

    摘要： The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides novel 1,4-benzodiazepine-2,5-dione compounds, and methods of using novel 1,4-benzodiazepine-2,5-dione compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.

    摘要翻译： 本发明涉及新型化合物，其发现方法及其治疗用途。 特别地，本发明提供了新的1,4-苯并二氮杂2,5-二酮化合物，以及使用新的1,4-苯并二氮杂2,5-二酮化合物作为治疗剂来治疗与 程序性细胞死亡，自身免疫，炎症，过度增生等过程的错误调节。

    Unsolvated benzodiazepine compositions and methods
    10.
    发明授权
    Unsolvated benzodiazepine compositions and methods 有权
    非溶剂型苯二氮卓组合物和方法

    公开(公告)号：US07994313B2

    公开(公告)日：2011-08-09

    申请号：US12473144

    申请日：2009-05-27

    申请人： Gary D. Glick ,  Adam Matzger

    发明人： Gary D. Glick ,  Adam Matzger

    IPC分类号： C07D243/24 ,  C07D403/04

    CPC分类号： C07D243/24 ,  A61K31/5513

    摘要： The present invention relates to systems and methods for generating new forms of benzodiazepine and benzodiazepine related compounds as well as new compounds and formulations generated by such methods. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline benzodiazepine and benzodiazepine related polymorphs and new unsolvated, solvated, and other forms of the compounds that find use as improved drugs and drug formations.

    摘要翻译： 本发明涉及用于产生苯并二氮杂和苯并二氮杂相关化合物的新形式的系统和方法，以及由这些方法产生的新化合物和制剂。 特别地，本发明提供了用于产生和鉴定新的结晶苯并二氮杂和苯并二氮杂相关多晶型物的新的非常溶剂化物，溶剂化物和其它形式的用于改进药物和药物形成的高通量系统和方法。