公开(公告)号：US09000014B2

公开(公告)日：2015-04-07

申请号：US13992254

申请日：2011-12-08

Applicant: Gary D. Glick ,  Alexander R. Hurd ,  Matthew N. Mattson ,  Clarke B. Taylor ,  Chad A. Van Huis

Inventor： Gary D. Glick ,  Alexander R. Hurd ,  Matthew N. Mattson ,  Clarke B. Taylor ,  Chad A. Van Huis

IPC: C07D213/75 ,  A61K31/44 ,  C07D213/76 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

CPC classification number: A61K31/44 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/444 ,  C07D213/75 ,  C07D213/76 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

Abstract: The invention provides pyridonyl guanidine compounds that inhibit F1F0-ATPase, and methods of using pyridonyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.

Abstract translation: 本发明提供抑制F1F0-ATP酶的吡啶酮胍化合物，以及使用吡啶酮胍化合物作为治疗药物治疗诸如免疫病症，炎性病症或癌症的医学病症的方法。

公开(公告)号：US08673897B2

公开(公告)日：2014-03-18

申请号：US13395566

申请日：2010-09-17

Applicant: Gary D. Glick ,  Alexander Ross Hurd ,  Chad Alan Van Huis

Inventor： Gary D. Glick ,  Alexander Ross Hurd ,  Chad Alan Van Huis

IPC: C07D243/18 ,  C07D243/12 ,  A61K31/55

CPC classification number: C07D403/04 ,  C07D243/24 ,  C07D243/26

Abstract: The invention provides 1,4-benzodiazepinone compounds, pharmaceutical compositions, and methods of treating autoimmune disorders, chronic inflammatory disorders, and hyperproliferative disorders. For example, the 1,4-benzodiazepinone compounds and pharmaceutical compositions are contemplated to be useful for treating rheumatoid arthritis, graft-versus-host disease, inflammatory bowel disease, and the like.

Abstract translation: 本发明提供1,4-苯并二氮杂酮化合物，药物组合物和治疗自身免疫疾病，慢性炎症性疾病和过度增殖性疾病的方法。 例如，1,4-苯并二氮杂酮化合物和药物组合物被认为可用于治疗类风湿性关节炎，移植物抗宿主病，炎症性肠病等。

公开(公告)号：US20130324536A1

公开(公告)日：2013-12-05

申请号：US13992255

申请日：2011-12-08

Applicant: Gary D. Glick ,  Alexander R. Hurd ,  Clarke B. Taylor ,  Chad A. Van Huis

Inventor： Gary D. Glick ,  Alexander R. Hurd ,  Clarke B. Taylor ,  Chad A. Van Huis

IPC: C07D231/38 ,  C07D413/14 ,  C07D401/14 ,  C07D417/12 ,  C07D413/12 ,  C07D405/12 ,  C07D487/14 ,  C07D401/12

CPC classification number: C07D231/38 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/5377 ,  C07D231/40 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/14

Abstract: The invention provides pyrazolyl guanidine compounds that inhibit F1Fo-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.

Abstract translation: 本发明提供了抑制F1Fo-ATP酶的吡唑基胍化合物，以及使用吡唑基胍化合物作为治疗药物治疗医学病症如免疫疾病，炎性病症或癌症的方法。

公开(公告)号：US20130190300A1

公开(公告)日：2013-07-25

申请号：US13717096

申请日：2012-12-17

Applicant: Gary D. Glick ,  Anthony W. Opipari

Inventor： Gary D. Glick ,  Anthony W. Opipari

IPC: C07D243/24

CPC classification number: C07D243/24 ,  A61K31/551 ,  A61K31/5513 ,  C07D243/14 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.

Abstract translation: 本发明涉及化合物，其发现方法及其治疗用途。 特别地，本发明提供了苯并二氮杂衍生物和使用苯并二氮杂衍生物作为治疗剂治疗与程序性细胞死亡，自身免疫，炎症和过度增殖等过程的错误调节相关的多种病症的方法。

公开(公告)号：US08415343B2

公开(公告)日：2013-04-09

申请号：US11643614

申请日：2006-12-21

Applicant: Gary D. Glick ,  Anthony W. Opipari

Inventor： Gary D. Glick ,  Anthony W. Opipari

IPC: A61K31/55 ,  A61K31/59 ,  A61K31/05

CPC classification number: C07D243/24 ,  A61K31/551 ,  A61K31/5513 ,  C07D243/14 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.

Abstract translation: 本发明涉及化合物，其发现方法及其治疗用途。 特别地，本发明提供了苯并二氮杂衍生物和使用苯并二氮杂衍生物作为治疗剂治疗与程序性细胞死亡，自身免疫，炎症和过度增殖等过程的错误调节相关的多种病症的方法。

公开(公告)号：US20120088757A1

公开(公告)日：2012-04-12

申请号：US13309233

申请日：2011-12-01

Applicant: Gary D. Glick

Inventor： Gary D. Glick

IPC: A61K31/5513 ,  A61P35/00 ,  A61P37/06 ,  C07D243/24 ,  C12N5/09

CPC classification number: C07D243/14 ,  A61K31/5513

Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides novel 1,4-benzodiazepine-2,5-dione compounds, and methods of using novel 1,4-benzodiazepine-2,5-dione compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.

Abstract translation: 本发明涉及新型化合物，其发现方法及其治疗用途。 特别地，本发明提供了新的1,4-苯并二氮杂2,5-二酮化合物，以及使用新的1,4-苯并二氮杂2,5-二酮化合物作为治疗剂来治疗与 程序性细胞死亡，自身免疫，炎症，过度增生等过程的错误调节。

公开(公告)号：US07994313B2

公开(公告)日：2011-08-09

申请号：US12473144

申请日：2009-05-27

Applicant: Gary D. Glick ,  Adam Matzger

Inventor： Gary D. Glick ,  Adam Matzger

IPC: C07D243/24 ,  C07D403/04

CPC classification number: C07D243/24 ,  A61K31/5513

Abstract: The present invention relates to systems and methods for generating new forms of benzodiazepine and benzodiazepine related compounds as well as new compounds and formulations generated by such methods. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline benzodiazepine and benzodiazepine related polymorphs and new unsolvated, solvated, and other forms of the compounds that find use as improved drugs and drug formations.

Abstract translation: 本发明涉及用于产生苯并二氮杂和苯并二氮杂相关化合物的新形式的系统和方法，以及由这些方法产生的新化合物和制剂。 特别地，本发明提供了用于产生和鉴定新的结晶苯并二氮杂和苯并二氮杂相关多晶型物的新的非常溶剂化物，溶剂化物和其它形式的用于改进药物和药物形成的高通量系统和方法。

公开(公告)号：US20090275099A1

公开(公告)日：2009-11-05

申请号：US11726219

申请日：2007-03-21

Applicant: Gary D. Glick

Inventor： Gary D. Glick

IPC: C12N9/99 ,  C07D403/06

CPC classification number: A61K31/5513 ,  A61K31/353 ,  A61K31/4174 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/406 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/465 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/478 ,  Y02A50/479 ,  Y02A50/483

Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, mitochondrial F1F0 ATP hydrolase associated disorders, and the like.

Abstract translation: 本发明涉及化合物，其发现方法及其治疗用途。 特别地，本发明提供化合物作为治疗与程序性细胞死亡，自身免疫，炎症，过度增殖，线粒体F1F0 ATP水解酶相关疾病等的过程的错误调节相关的许多病症的治疗剂。

公开(公告)号：US20090012065A1

公开(公告)日：2009-01-08

申请号：US11807046

申请日：2007-05-25

Applicant: Gary D. Glick ,  Anthony W. Opipari, JR.

Inventor： Gary D. Glick ,  Anthony W. Opipari, JR.

IPC: A61K31/5513 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00

CPC classification number: C07D243/14 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  C07D243/24 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

Abstract: Benzodiazepine compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of the following structures: wherein R1, R2, R3 and R4 are as defined. The invention also includes enantiomers, pharmaceutically acceptable salts, prodrugs or derivatives of the benzodiazepine compounds. Any one or more of these benzodiazepine compounds can be used to treat a variety of dysregulatory disorders related to cellular death. Such disorders include autoimmune disorders, inflammatory conditions, hyperproliferative conditions, viral infections, and atherosclerosis. In addition, the above compounds can be used to prepare medicaments to treat the above-described dysregulatory disorders. The benzodiazepines can also be used in drug screening assays and other diagnostic methods.

Abstract translation: 提供了苯二氮卓类化合物，以及使用这些化合物的方法。 一些苯并二氮杂化合物包括以下结构的1,4-苯并二氮杂-2-酮和1,4-苯并二吖庚因-2,5-二酮化合物：其中R1，R2，R3和R4如上定义。 本发明还包括苯并二氮杂化合物的对映异构体，药学上可接受的盐，前药或衍生物。 这些苯二氮卓类化合物中的任何一种或多种可用于治疗与细胞死亡相关的各种异常调节性疾病。 这些疾病包括自身免疫性疾病，炎性病症，过度增殖病症，病毒感染和动脉粥样硬化。 此外，上述化合物可用于制备治疗上述失调调节障碍的药物。 苯并二氮杂类也可用于药物筛选试验和其他诊断方法。

公开(公告)号：US07276348B2

公开(公告)日：2007-10-02

申请号：US10795535

申请日：2004-03-08

Applicant: Gary D. Glick

Inventor： Gary D. Glick

IPC: C12Q1/42

CPC classification number: C07D403/12 ,  A61K31/551 ,  A61K31/5513 ,  C07D243/14 ,  C07D243/24 ,  C07D401/12 ,  C07D413/12

Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.

Abstract translation: 本发明涉及新型化合物，其发现方法及其治疗用途。 特别地，本发明提供了苯并二氮杂衍生物和使用苯并二氮杂衍生物作为治疗剂治疗与程序性细胞死亡，自身免疫，炎症和过度增殖等过程的错误调节相关的多种病症的方法。