公开(公告)号：US08124105B2

公开(公告)日：2012-02-28

申请号：US12489846

申请日：2009-06-23

申请人： Gary H. Cohen ,  Roselyn J. Eisenbert ,  John Charles Whitbeck ,  Lydia Aldaz-Carroll ,  Bernard Moss ,  Shlomo Lustig ,  Christiana Fogg

发明人： Gary H. Cohen ,  Roselyn J. Eisenbert ,  John Charles Whitbeck ,  Lydia Aldaz-Carroll ,  Bernard Moss ,  Shlomo Lustig ,  Christiana Fogg

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/295 ,  A61K39/275 ,  C07H21/02

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/285 ,  A61K2039/505 ,  A61K2039/53 ,  C07K16/081 ,  C07K2317/76 ,  C12N2710/24122 ,  C12N2710/24134

摘要： The invention is directed to a poxvirus vaccine comprising a soluble truncated poxvirus envelope protein. The invention is also directed to a vaccine comprising a nucleic acid encoding such proteins. Also included is an antibody which specifically binds to the proteins and nucleic acid encoding the same, as well as methods of preventing and treating a poxvirus infection using the afore-mentioned vaccine, antibody, protein, and nucleic acid encoding them.

摘要翻译： 本发明涉及包含可溶性截短痘病毒包膜蛋白的痘病毒疫苗。 本发明还涉及包含编码这种蛋白质的核酸的疫苗。 还包括特异性结合蛋白质的抗体及其编码的核酸，以及使用上述疫苗，抗体，蛋白质和编码它们的核酸来预防和治疗痘病毒感染的方法。

公开(公告)号：US20100021484A1

公开(公告)日：2010-01-28

申请号：US12489846

申请日：2009-06-23

申请人： Gary H. Cohen ,  Roselyn J. Eisenbert ,  John Charles Whitbeck ,  Lydia Aldaz-Carroll ,  Bernard Moss ,  Shlomo Lustig ,  Christiana Fogg

发明人： Gary H. Cohen ,  Roselyn J. Eisenbert ,  John Charles Whitbeck ,  Lydia Aldaz-Carroll ,  Bernard Moss ,  Shlomo Lustig ,  Christiana Fogg

IPC分类号： A61K39/00 ,  C07H21/00 ,  A61P37/04

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/285 ,  A61K2039/505 ,  A61K2039/53 ,  C07K16/081 ,  C07K2317/76 ,  C12N2710/24122 ,  C12N2710/24134

摘要： The invention is directed to a poxvirus vaccine comprising a soluble truncated poxvirus envelope protein. The invention is also directed to a vaccine comprising a nucleic acid encoding such proteins. Also included is an antibody which specifically binds to the proteins and nucleic acid encoding the same, as well as methods of preventing and treating a poxvirus infection using the afore-mentioned vaccine, antibody, protein, and nucleic acid encoding them.

摘要翻译： 本发明涉及包含可溶性截短痘病毒包膜蛋白的痘病毒疫苗。 本发明还涉及包含编码这种蛋白质的核酸的疫苗。 还包括特异性结合蛋白质的抗体及其编码的核酸，以及使用上述疫苗，抗体，蛋白质和编码它们的核酸来预防和治疗痘病毒感染的方法。

公开(公告)号：US07560116B2

公开(公告)日：2009-07-14

申请号：US11010979

申请日：2004-12-13

申请人： Gary H. Cohen ,  Roselyn J. Eisenberg ,  John Charles Whitbeck ,  Lydia Aldaz-Carroll ,  Bernard Moss ,  Shlomo Lustig ,  Christiana Fogg

发明人： Gary H. Cohen ,  Roselyn J. Eisenberg ,  John Charles Whitbeck ,  Lydia Aldaz-Carroll ,  Bernard Moss ,  Shlomo Lustig ,  Christiana Fogg

IPC分类号： A61K39/38 ,  A61K39/12 ,  A61K39/295 ,  A61K39/285 ,  C07K17/00 ,  A61K39/187

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/285 ,  A61K2039/505 ,  A61K2039/53 ,  C07K16/081 ,  C07K2317/76 ,  C12N2710/24122 ,  C12N2710/24134

摘要： The invention is directed to a poxvirus vaccine comprising a soluble truncated poxvirus envelope protein. The invention is also directed to a vaccine comprising a nucleic acid encoding such proteins. Also included is an antibody which specifically binds to the proteins and nucleic acid encoding the same, as well as methods of preventing and treating a poxvirus infection using the afore-mentioned vaccine, antibody, protein, and nucleic acid encoding them.

摘要翻译： 本发明涉及包含可溶性截短痘病毒包膜蛋白的痘病毒疫苗。 本发明还涉及包含编码这种蛋白质的核酸的疫苗。 还包括特异性结合蛋白质的抗体及其编码的核酸，以及使用上述疫苗，抗体，蛋白质和编码它们的核酸来预防和治疗痘病毒感染的方法。

公开(公告)号：US20060062800A1

公开(公告)日：2006-03-23

申请号：US11010979

申请日：2004-12-13

申请人： Gary Cohen ,  Roselyn Eisenberg ,  John Whitbeck ,  Lydia Aldaz-Carroll ,  Bernard Moss ,  Shlomo Lustig ,  Christiana Fogg

发明人： Gary Cohen ,  Roselyn Eisenberg ,  John Whitbeck ,  Lydia Aldaz-Carroll ,  Bernard Moss ,  Shlomo Lustig ,  Christiana Fogg

IPC分类号： C12Q1/70 ,  A61K39/12 ,  C07K14/065

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/285 ,  A61K2039/505 ,  A61K2039/53 ,  C07K16/081 ,  C07K2317/76 ,  C12N2710/24122 ,  C12N2710/24134

摘要： The invention is directed to a poxvirus vaccine comprising a soluble truncated poxvirus envelope protein. The invention is also directed to a vaccine comprising a nucleic acid encoding such proteins. Also included is an antibody which specifically binds to the proteins and nucleic acid encoding the same, as well as methods of preventing and treating a poxvirus infection using the afore-mentioned vaccine, antibody, protein, and nucleic acid encoding them.