公开(公告)号：US12115218B2

公开(公告)日：2024-10-15

申请号：US17312441

申请日：2019-04-17

申请人： LUOYANG SEIWEI BIOTECHNOLOGIES CO., LTD.

发明人： Kegong Tian ,  Yongmei Liu ,  Xuke Zhang

IPC分类号： A61K39/39 ,  A61K39/02 ,  A61K39/12 ,  A61K39/187 ,  A61K39/245 ,  A61P31/04 ,  A61P31/20 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K39/0241 ,  A61K39/12 ,  A61K39/187 ,  A61K39/245 ,  A61P31/04 ,  A61P31/20 ,  A61K2039/5252 ,  A61K2039/55511 ,  A61K2039/55577

摘要： The present disclosure provides an adjuvant composition containing 0.2%-15% w/v carbomer, 0.1%-0.5% w/v lecithin, and 0.03%-0.2% w/v ginsenoside. The adjuvant composition of the present disclosure cannot only ensure the long-term clarification and/or stability of the vaccine, but also can effectively stimulate the inactivated antigens and subunit antigens therein to produce high-titer antibodies for immune protection. The inactivated vaccines or subunit vaccines prepared by the adjuvant composition of the present disclosure can be used as a diluent for freeze-dried live virus antigens and has no toxic effect on the live virus antigens.

公开(公告)号：US20170128563A1

公开(公告)日：2017-05-11

申请号：US15259725

申请日：2016-09-08

申请人： The United States of America, as Represented by the Secretary of Agriculture

发明人： Manuel V. Borca ,  Douglas P. Gladue ,  Lauren G. Holinka-Patterson ,  Vivian O'Donnell ,  Jose Nieva

IPC分类号： A61K39/187 ,  C12N7/00

CPC分类号： A61K39/187 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/543 ,  A61K2039/552 ,  C12N7/00 ,  C12N2770/24321 ,  C12N2770/24334

摘要： The role of a specific E2 region, 869CKWGGNWTCV878, containing a putative fusion peptide (FP) sequence was evaluated. FPs critically contribute to the interaction between proteins and the membrane system of the host cell. Reverse genetics utilizing a full-length infectious clone of the highly virulent CSFV strain Brescia (BICv) was used to evaluate how amino acid substitutions within this region of E2 may affect replication of BICv in cell cultures and affect virus virulence in swine. A recombinant CSFV (FPi.c) containing mutations in three amino acid residues within the E2 protein area comprised CSFV amino acid residues 869-878 was constructed: W871T, W875D, and V878T. Interestingly, mutated virus FPi.c was completely attenuated when inoculated intranasally at a dose of 105 TCID50 in swine. Importantly, animals infected with FPi.c virus were protected against the virulent challenge with Brescia virus at 3 and 28 days after vaccination. Protection was evidenced by absence of clinical signs related with CSF as well as the absence of viremia produced by the challenge virulent virus.

公开(公告)号：US09315873B2

公开(公告)日：2016-04-19

申请号：US13698580

申请日：2011-05-18

申请人： Martin Beer ,  Sandra Blome ,  Immanuel Leifer

发明人： Martin Beer ,  Sandra Blome ,  Immanuel Leifer

IPC分类号： A61K39/12 ,  A61K39/187 ,  C12Q1/70 ,  C12N7/08 ,  C07K14/005 ,  G01N33/569 ,  A61K39/00

CPC分类号： C12Q1/70 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/542 ,  A61K2039/552 ,  A61K2039/6081 ,  C07K14/005 ,  C12N2770/24322 ,  C12N2770/24334 ,  G01N33/56983

摘要： The invention relates to a marker vaccine for prophylactic treatment of classical swine fever comprising modified live attenuated classical swine fever virus. The viral amino acid sequence of the TAV-epitope of the E2 protein comprises a different sequence from that of a wild-type classical swine fever virus. The invention relates to pharmaceutical compositions of the marker vaccine. The invention also relates to a method of manufacturing marker vaccines for prevention of classical swine fever using selective antibody pressure.

摘要翻译： 本发明涉及一种用于预防性治疗经典猪瘟的标记疫苗，其包含改良的减毒经典猪瘟病毒。 E2蛋白的TAV-表位的病毒氨基酸序列包含与野生型经典猪瘟病毒不同的序列。 本发明涉及标记疫苗的药物组合物。 本发明还涉及使用选择性抗体压力制备用于预防传统猪瘟的标记疫苗的方法。

公开(公告)号：US5965134A

公开(公告)日：1999-10-12

申请号：US937102

申请日：1997-09-24

申请人： Heinz-Jurgen Thiel ,  Knut Elbers ,  Thomas Pauly

发明人： Heinz-Jurgen Thiel ,  Knut Elbers ,  Thomas Pauly

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61K39/12 ,  A61K39/187 ,  A61P31/12 ,  C07K14/18 ,  C07K14/185 ,  C12N5/10 ,  C12N15/40 ,  C12P21/02 ,  C12R1/91 ,  C12N15/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2770/24322

摘要： This application is concerned with immunogenic polypeptides of pestiviruses, specifically Classical Swine Fever Virus (CVFV), specifically the nonstructural protein p10, more specifically T-cell epitopes from this protein and nucleic acid molecules encoding these polypeptides, and vaccines and diagnostics with these polypeptides or nucleic acid molecules.

摘要翻译： 该应用涉及瘟病毒的免疫原性多肽，特别是经典猪瘟病毒（CVFV），特别是非结构蛋白质p10，更具体地来自该蛋白质的T细胞表位和编码这些多肽的核酸分子，以及用这些多肽的疫苗和诊断 核酸分子。

公开(公告)号：US5935582A

公开(公告)日：1999-08-10

申请号：US59853

申请日：1998-04-14

申请人： Gregor Meyers ,  Tillmann Rumenapf ,  Heinz-Jurgen Thiel

发明人： Gregor Meyers ,  Tillmann Rumenapf ,  Heinz-Jurgen Thiel

IPC分类号： A61P31/12 ,  C07K14/18 ,  G01N33/569 ,  A61K39/187 ,  A61K39/00 ,  C12Q1/70 ,  G01N33/53

CPC分类号： C07K14/005 ,  G01N33/56983 ,  A61K2039/525 ,  C12N2770/24322

摘要： The present invention is concerned with a hog cholera virus vaccine comprising a polypeptide characteristic of hog cholera virus. Vector vaccines capable to express a nucleic acid sequence encoding such a polypeptide also from part of the present invention. Said polypeptide and nucleic acid sequence can also be used for the detection of hog cholera virus infection.

摘要翻译： 本发明涉及一种猪霍乱病毒疫苗，其包含猪霍乱病毒特征的多肽。 也可以从本发明的一部分表达编码这种多肽的核酸序列的载体疫苗。 所述多肽和核酸序列也可用于检测猪霍乱病毒感染。

公开(公告)号：US3489834A

公开(公告)日：1970-01-13

申请号：US3489834D

申请日：1961-12-01

申请人： CORNELL RES FOUNDATION INC

发明人： BAKER JAMES A

IPC分类号： A61K39/187 ,  C12K1/06 ,  C12K5/00 ,  C12K7/00

CPC分类号： A61K39/187 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/552 ,  C12N2770/24334

公开(公告)号：US08409587B2

公开(公告)日：2013-04-02

申请号：US10533464

申请日：2003-10-30

申请人： Yves Mayeresse ,  Jean Stephenne

发明人： Yves Mayeresse ,  Jean Stephenne

IPC分类号： A61K39/295 ,  A61K39/187

CPC分类号： A61K39/13 ,  A61K39/12 ,  C12N2770/32634 ,  Y02A50/466

摘要： The present invention relates to immunogenic compositions comprising a dried solid or highly viscous liquid formulation of inactivated polio virus (IPV) and a stabilizing agent wherein the IPV retains its antigenicity and/or immunogenicity. Methods of producing a dried formulation of IPV which retains its antigenicity/immunogenicity are described.

摘要翻译： 本发明涉及免疫原性组合物，其包含灭活脊髓灰质炎病毒（IPV）的干燥固体或高粘度液体制剂和其中IPV保持其抗原性和/或免疫原性的稳定剂。 描述了产生保留其抗原性/免疫原性的IPV干燥制剂的方法。

公开(公告)号：US08043856B2

公开(公告)日：2011-10-25

申请号：US12139183

申请日：2008-06-13

申请人： Yoshihiro Kawaoka ,  Makoto Ozawa

发明人： Yoshihiro Kawaoka ,  Makoto Ozawa

IPC分类号： C12N15/00 ,  C12N5/10 ,  C12N7/02 ,  A61K39/187

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C12N2710/10343 ,  C12N2710/10351 ,  C12N2740/10043 ,  C12N2760/16022 ,  C12N2760/16122 ,  C12N2760/16134

摘要： The invention provides adenovirus and retrovirus vectors useful to prepare influenza virus. Also provided is a canine RNA polymerase I promoter and vectors having that promoter.

摘要翻译： 本发明提供了可用于制备流感病毒的腺病毒和逆转录病毒载体。 还提供了犬RNA聚合酶I启动子和具有该启动子的载体。

公开(公告)号：US5811103A

公开(公告)日：1998-09-22

申请号：US873759

申请日：1997-06-12

申请人： Gregor Meyers ,  Tillmann Rumenapf ,  Heinz-Jurgen Thiel

发明人： Gregor Meyers ,  Tillmann Rumenapf ,  Heinz-Jurgen Thiel

IPC分类号： A61K39/00 ,  A61P31/14 ,  C07K14/18 ,  A61K39/187 ,  A61K39/38

CPC分类号： C07K14/005 ,  A61K2039/525 ,  A61K39/00 ,  C12N2770/24322

摘要： The present invention is concerned with a hog cholera virus vaccine comprising a polypeptide characteristic of hog cholera virus. Vector vaccines capable to express a nucleic acid sequence encoding such a polypeptide also form part of the present invention. Said polypeptide and nucleic acid sequence can also be used for the detection of hog cholera virus infection.

公开(公告)号：US3456053A

公开(公告)日：1969-07-15

申请号：US3456053D

申请日：1966-05-06

申请人： PFIZER & CO C

发明人： CRAWFORD JAMES G

IPC分类号： A61K39/187 ,  A61K23/00 ,  C12K5/00

CPC分类号： A61K39/187 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  C12N2770/24334