公开(公告)号：US5755231A

公开(公告)日：1998-05-26

申请号：US442672

申请日：1995-05-17

申请人： Gary Krantz ,  Shuenn-Tzong Chen ,  Adam Zipp ,  Joanne Zeng

发明人： Gary Krantz ,  Shuenn-Tzong Chen ,  Adam Zipp ,  Joanne Zeng

IPC分类号： G01N33/52 ,  A61B5/00

CPC分类号： G01N33/525

摘要： A test strip includes a first layer and an overlying differential flow-retarding layer that reduces the fraction of a component of a liquid specimen percolated therethrough. An inert backing, preferably having an aperture therethrough, overlies the flow-retarding layer. For the testing of a blood specimen, the flow-retarding layer is formed of glass fibers that reduce the fraction of red blood cells in the percolate, leaving primarily, but not entirely, plasma in the percolate. The first layer includes chemicals that react with a component of the plasma such as glucose in a measurable reaction, preferably a visually measurable reaction. In using this test strip, the blood specimen is placed into the aperture of the backing and permitted to percolate through the flow-retarding layer such that a fraction of the red blood cells is removed from the percolate. The chemicals in the first layer react with the glucose in the plasma to produce a change that is visually measurable from the bottom side of the active layer with reduced visual interference from the red color of whole blood on the bottom side of the reaction layer.

摘要翻译： 测试条包括第一层和上覆的差分阻流层，其减少通过其渗透的液体样品的组分的分数。 优选具有穿过其中的孔的惰性背衬覆盖在阻流层上。 为了测试血液样本，阻滞层由玻璃纤维形成，玻璃纤维减少了渗滤液中红细胞的分数，主要而不是完全留在渗滤液中的血浆。 第一层包括在可测量的反应中，优选视觉上可测量的反应与等离子体组分如葡萄糖反应的化学物质。 在使用该测试条时，将血液样本放入背衬的孔中并允许渗透通过阻滞层，使得从渗滤液中除去一部分红细胞。 第一层中的化学物质与等离子体中的葡萄糖反应，产生从活性层底部可视化测量的变化，减少了反应层底部全血红色的视觉干扰。

公开(公告)号：US4649121A

公开(公告)日：1987-03-10

申请号：US705711

申请日：1985-02-26

申请人： Ibrahim A. Ismail ,  Paul Hemmes ,  Mark T. Skarstedt ,  Adam Zipp

发明人： Ibrahim A. Ismail ,  Paul Hemmes ,  Mark T. Skarstedt ,  Adam Zipp

IPC分类号： G01N33/66 ,  C12Q1/54 ,  G01N21/78 ,  G01N31/22 ,  G01N33/50 ,  G01N33/52 ,  G01N35/00

CPC分类号： G01N33/521 ,  C12Q1/54 ,  Y10T436/104998

摘要： A viability test device wherein the viability of a test composition for the determination of an analyte of interest can be determined by simply wetting the device with ordinary water. The viability device can be prepared in three formats: a control or calibrator device, an internal control device and a self indicating device. Unreacted analyte, or an analog thereof, can be incorporated in a limited defined portion of a dried carrier matrix incorporated with a test composition to provide an internal control test device. When wetted with water, a positive optical response, usually color, indicates the test composition can provide a viable test for the analyte. The internal control test device is particularly advantageously used by diabetics in their own homes where a negative test response could be due to the desired control of the user's condition or due to deterioration of a test composition because of unfavorable storage conditions.

公开(公告)号：US4683209A

公开(公告)日：1987-07-28

申请号：US887723

申请日：1986-07-21

申请人： Ibrahim A. Ismail ,  Paul Hemmes ,  Mark T. Skarstedt ,  Adam Zipp

发明人： Ibrahim A. Ismail ,  Paul Hemmes ,  Mark T. Skarstedt ,  Adam Zipp

IPC分类号： C12Q1/54 ,  G01N33/52 ,  G01N31/00

CPC分类号： G01N21/81 ,  C12Q1/54 ,  G01N33/52 ,  Y10T436/10 ,  Y10T436/104998

摘要： A viability test device wherein the viability of a test composition for the determination of an analyte of interest can be determined by simply wetting the device with ordinary water. The viability device can be prepared in three formats: a control or calibrator device, an internal control device and a self indicating device. Unreacted analyte, or an analog thereof, can be incorporated in a limited defined portion of a dried carrier matrix incorporated with a test composition to provide an internal control test device. When wetted with water, a positive optical response, usually color, indicates the test composition can provide a viable test for the analyte. The internal control test device is particularly advantageously used by diabetics in their own homes where a negative test response could be due to the desired control of the user's condition or due to deterioration of a test composition because of unfavorable storage conditions.

摘要翻译： 活力试验装置，其中用于测定感兴趣分析物的测试组合物的活力可通过简单地用普通水润湿该装置来确定。 活力装置可以以三种格式制备：控制或校准装置，内部控制装置和自我指示装置。 未反应的分析物或其类似物可以掺入含有测试组合物的干燥的载体基质的限定部分中以提供内部对照测试装置。 当用水润湿时，正光学响应（通常为颜色）表明测试组合物可以为分析物提供可行的测试。 内部控制测试装置特别有利地用于其本身的糖尿病患者，其中负面测试响应可能是由于对用户状况的期望控制或由于不利的储存条件而导致的测试组合物的劣化。