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公开(公告)号：US08343496B2
公开(公告)日：2013-01-01
申请号：US12891169
申请日：2010-09-27
CPC分类号： A61K39/395 , A61K45/00 , A61K47/6913 , A61K51/1234 , A61K2039/505 , C07K16/2803 , C07K16/2833 , C07K16/2896 , C07K2317/24 , G01N33/574 , G01N2333/70596 , G01N2800/245 , A61K2300/00
摘要： Disclosed are compositions that include anti-CD74 immunoconjugates and a therapeutic and/or diagnostic agent. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. The compositions may be part of a kit for administering the anti-CD74 immunoconjugate compositions in therapeutic and/or diagnostic methods.
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公开(公告)号：US07829064B2
公开(公告)日：2010-11-09
申请号：US10706852
申请日：2003-11-12
CPC分类号： A61K39/395 , A61K45/00 , A61K47/6913 , A61K51/1234 , A61K2039/505 , C07K16/2803 , C07K16/2833 , C07K16/2896 , C07K2317/24 , G01N33/574 , G01N2333/70596 , G01N2800/245 , A61K2300/00
摘要： Disclosed are compositions that include anti-CD74 immunoconjugates and a therapeutic and/or diagnostic agent. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates compositions in therapeutic and/or diagnostic methods.
摘要翻译： 公开了包含抗CD74免疫偶联物和治疗和/或诊断剂的组合物。 还公开了在诊断和治疗过程中制备免疫缀合物和使用免疫缀合物的方法。 组合物可以是用于在治疗和/或诊断方法中施用抗CD74免疫偶联物组合物的试剂盒的一部分。
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公开(公告)号：US5601825A
公开(公告)日：1997-02-11
申请号：US452131
申请日：1995-05-26
IPC分类号： A61K38/00 , A61K31/00 , A61K38/22 , A61K38/43 , A61K39/395 , A61K47/48 , A61K51/10 , A61K51/12 , A61P31/00 , A61P35/00 , A61P35/02 , C07K14/435 , C07K16/06 , C07K16/10 , C07K16/18 , C07K16/30 , G01N33/534 , G01N33/68 , C07K16/20 , C07K19/00
CPC分类号： A61K51/10 , A61K47/48523 , A61K47/48569 , A61K51/1018 , A61K51/1048 , A61K51/1093 , A61K51/1282 , C07K16/065 , C07K16/1063 , C07K16/30 , G01N33/534 , G01N33/6857 , A61K2121/00 , A61K2123/00 , A61K38/00
摘要： Provided are conjugates useful in cancer or infectious disease therapy. The conjugate is a drug or modified toxin which is a native toxin devoid of a functioning receptor binding domain and a protein which reacts with a substance associated with a targeted cell or pathogen. The targeted substance internalizes the conjugate into the cell cytoplasm, and the kills the cell. The protein prior to conjugation has at least one mercapto group which becomes a site for conjugation to the toxin or drug. Also provided are methods of therapy, methods for producing the conjugate and pharmaceuticals compositions of the conjugates.
摘要翻译： 提供可用于癌症或感染性疾病治疗的缀合物。 缀合物是药物或修饰的毒素，其是没有功能受体结合结构域的天然毒素和与靶向细胞或病原体相关的物质发生反应的蛋白质。 靶向物质将结合物内化为细胞质，杀死细胞。 缀合前的蛋白质具有至少一个巯基，其成为与毒素或药物缀合的位点。 还提供了治疗方法，生产缀合物的方法和缀合物的药物组合物。
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公开(公告)号：US07300644B2
公开(公告)日：2007-11-27
申请号：US10361026
申请日：2003-02-10
CPC分类号： A61K33/22 , A61K31/7088 , A61K33/24 , A61K38/465 , A61K45/06 , A61K47/645 , A61K47/665 , A61K47/6853 , A61K47/6893 , A61K47/6898 , A61K51/0497 , A61K51/065 , A61K51/10 , A61K51/1096 , B82Y5/00 , Y02A50/463 , A61K2300/00
摘要： The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities, and wherein the therapeutic agents are delivered to the tumor sites using combined targeting and pre-targeting methods. The methods of the present invention achieve good tumor to non-tumor ratios of the therapeutic agents, and are effective for cancer therapy.
摘要翻译： 本发明涉及用于治疗癌症的方法，其中使用多于一种治疗剂，每种治疗剂具有不同的杀伤能力，并且其中使用组合靶向和预靶向将治疗剂递送至肿瘤部位 方法。 本发明的方法实现了治疗剂的非肿瘤比例的良好肿瘤，并且对于癌症治疗是有效的。
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公开(公告)号：US07931890B2
公开(公告)日：2011-04-26
申请号：US11210684
申请日：2005-08-25
CPC分类号： A61K33/22 , A61K31/7088 , A61K33/24 , A61K38/465 , A61K45/06 , A61K47/645 , A61K47/665 , A61K47/6853 , A61K47/6893 , A61K47/6898 , A61K51/0497 , A61K51/065 , A61K51/10 , A61K51/1096 , B82Y5/00 , Y02A50/463 , A61K2300/00
摘要： The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities, and wherein the therapeutic agents are delivered to the tumor sites using combined targeting and pre-targeting methods. The methods of the present invention achieve good tumor to non-tumor ratios of the therapeutic agents, and are effective for cancer therapy.
摘要翻译： 本发明涉及用于治疗癌症的方法，其中使用多于一种治疗剂，每种治疗剂具有不同的杀伤能力，并且其中使用组合靶向和预靶向将治疗剂递送至肿瘤部位 方法。 本发明的方法实现了治疗剂的非肿瘤比例的良好肿瘤，并且对于癌症治疗是有效的。
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公开(公告)号：US07514066B2
公开(公告)日：2009-04-07
申请号：US11872139
申请日：2007-10-15
CPC分类号： A61K51/109 , A61K31/70 , A61K38/02 , A61K38/465 , A61K47/645 , A61K47/665 , A61K47/6853 , A61K47/6893 , A61K47/6898 , A61K51/0497 , A61K51/065 , B82Y5/00 , C07K16/4266
摘要： The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities, and wherein the therapeutic agents are delivered to the tumor sites using combined targeting and pre-targeting methods. The methods of the present invention achieve good tumor to non-tumor ratios of the therapeutic agents, and are effective for cancer therapy.
摘要翻译： 本发明涉及用于治疗癌症的方法，其中使用多于一种治疗剂，每种治疗剂具有不同的杀伤能力，并且其中使用组合靶向和预靶向将治疗剂递送至肿瘤部位 方法。 本发明的方法实现了治疗剂的非肿瘤比例的良好肿瘤，并且对于癌症治疗是有效的。
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公开(公告)号：US07011812B1
公开(公告)日：2006-03-14
申请号：US09597580
申请日：2000-06-20
CPC分类号： A61K33/22 , A61K31/7088 , A61K33/24 , A61K38/465 , A61K45/06 , A61K47/645 , A61K47/665 , A61K47/6853 , A61K47/6893 , A61K47/6898 , A61K51/0497 , A61K51/065 , A61K51/10 , A61K51/1096 , B82Y5/00 , Y02A50/463 , A61K2300/00
摘要： The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities, and wherein the therapeutic agents are delivered to the tumor sites using combined targeting and pre-targeting methods. The methods of the present invention achieve good tumor to non-tumor ratios of the therapeutic agents, and are effective for cancer therapy.
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公开(公告)号：US06558648B1
公开(公告)日：2003-05-06
申请号：US09597580
申请日：2000-06-20
IPC分类号： A61K5100
摘要： The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities, and wherein the therapeutic agents are delivered to the tumor sites using combined targeting and pre-targeting methods. The methods of the present invention achieve good tumor to non-tumor ratios of the therapeutic agents, and are effective for cancer therapy.
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公开(公告)号：US5541297A
公开(公告)日：1996-07-30
申请号：US882177
申请日：1992-05-11
IPC分类号： A61K38/00 , A61K31/00 , A61K38/22 , A61K38/43 , A61K39/395 , A61K47/48 , A61K51/10 , A61K51/12 , A61P31/00 , A61P35/00 , A61P35/02 , C07K14/435 , C07K16/06 , C07K16/10 , C07K16/18 , C07K16/30 , G01N33/534 , G01N33/68 , C07K16/46
CPC分类号： A61K51/10 , A61K47/48523 , A61K47/48569 , A61K51/1018 , A61K51/1048 , A61K51/1093 , A61K51/1282 , C07K16/065 , C07K16/1063 , C07K16/30 , G01N33/534 , G01N33/6857 , A61K2121/00 , A61K2123/00 , A61K38/00
摘要： Provided are conjugates useful in cancer or infectious disease therapy. The conjugate is a drug or modified toxin which is a native toxin devoid of a functioning receptor binding domain and a protein which reacts with a substance associated with a targeted cell or pathogen. The targeted substance internalizes the conjugate into the cell cytoplasm, and the kills the cell. The protein prior to conjugation has at least one mercapto group which becomes a site for conjugation to the toxin or drug. Also provided are methods of therapy, methods for producing the conjugate and pharmaceuticals compositions of the conjugates.
摘要翻译： 提供可用于癌症或感染性疾病治疗的缀合物。 缀合物是药物或修饰的毒素，其是没有功能受体结合结构域的天然毒素和与靶向细胞或病原体相关的物质发生反应的蛋白质。 靶向物质将结合物内化为细胞质，杀死细胞。 缀合前的蛋白质具有至少一个巯基，其成为与毒素或药物缀合的位点。 还提供了治疗方法，生产缀合物的方法和缀合物的药物组合物。
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公开(公告)号：US08361464B2
公开(公告)日：2013-01-29
申请号：US12564335
申请日：2009-09-22
IPC分类号： A61K39/395 , A61K51/00
CPC分类号： A61K47/48569 , A61K31/704 , A61K31/7056 , A61K31/706 , A61K45/06 , A61K47/6809 , A61K47/6849 , A61K47/6889 , C07H17/00 , C07H17/02 , C07K16/18 , C07K16/2896
摘要： The invention relates to therapeutic conjugates with the ability to target various antigens. The conjugates contain a targeting antibody or antigen binding fragment thereof and an anthracycline chemotherapeutic drug. The targeting antibody and the chemotherapeutic drug are linked via a linker comprising a hydrazide moiety.
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