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    Process for producing hyper-comb-branched polymers
    2.
    发明授权
    Process for producing hyper-comb-branched polymers 失效
    生产超梳型支化聚合物的方法

    公开(公告)号：US5631329A

    公开(公告)日：1997-05-20

    申请号：US408833

    申请日：1995-03-21

    申请人： Rui Yin ,  Donald A. Tomalia ,  David M. Hedstrand ,  Douglas R. Swanson

    发明人： Rui Yin ,  Donald A. Tomalia ,  David M. Hedstrand ,  Douglas R. Swanson

    IPC分类号： A61K47/48 ,  C08G69/44 ,  C08G69/48 ,  C08G73/02 ,  C08G83/00 ,  C08G85/00 ,  C08F293/00

    CPC分类号： B82Y5/00 ,  A61K47/48961 ,  C08G69/44 ,  C08G69/48 ,  C08G73/0206 ,  C08G73/0233 ,  C08G83/005 ,  C08G85/00 ,  Y10S525/902

    摘要： The specification discloses a process for producing poly-branched polymer having relatively high molecular weight by forming a first set of branches by polymerizing monomers which are either protected against or are non-reactive to branching and grafting during polymerization, grafting that first set of branches to a core having a plurality of reactive sites capable of reacting with the reactive end units of said branches, either deprotecting or activating a plurality of monomeric units on each of said branches to create branch reactive sites, forming a second set of branches in the same manner as the first set of branches were formed, grafting the second set of branches to the first set of branches by reacting the reactive end units of the second set of branches with each said branch reactive site on said first set of branches and repeating the foregoing steps reiteratively to form and attach subsequent sets of branches to prior branch sets until a desired number of iterations has been effected.

    摘要翻译： 本说明书公开了一种制备具有相对较高分子量的多支化聚合物的方法，通过聚合单体聚合形成第一组分支，所述单体在聚合过程中被保护为不支化或不反应支化和接枝，将第一组分支移植到 具有能够与所述分支的反应性末端单元反应的多个反应性位点的核心，在每个所述分支上去保护或活化多个单体单元以产生分支反应位点，以相同方式形成第二组分支 作为第一组分支形成，通过使第二组分支的反应性末端单元与所述第一组分支上的每个所述分支反应位点反应，将第二组分支移植到第一组分支，并重复上述步骤 重复地将随后的分支集合形成并附加到先前的分支集合，直到所需的迭代次数为蜜蜂 n影响。

    Starch hydrolysates as sequesterers
    3.
    发明授权
    Starch hydrolysates as sequesterers 失效
    淀粉水解作为螯合剂

    公开(公告)号：US5629090A

    公开(公告)日：1997-05-13

    申请号：US476730

    申请日：1995-06-07

    申请人： James E. Eastman

    发明人： James E. Eastman

    IPC分类号： A23L1/015 ,  A23L1/09 ,  A23L1/22 ,  A61K9/62 ,  A61K47/48 ,  B01F17/56 ,  C08B30/12 ,  B01J13/02 ,  C08B37/16 ,  C13K1/06

    CPC分类号： B82Y5/00 ,  A23L27/75 ,  A23L29/35 ,  A23L5/273 ,  A61K47/4823 ,  A61K47/48961 ,  C08B30/12 ,  Y10S516/01 ,  Y10T428/2984

    摘要： A starch hydrolysate composition is particularly suited for use as a sequesterer, i.e., it readily interacts noncovalently with other molecules to form stable inclusion complexes which are useful in a variety of applications. The starch molecules in the composition which act as sequesterers are in the form of single helical inclusion complexes with starch molecules having a D.P. of about 10 to 200 and a weight-average D.P. of about 10 to 50 as the host molecule holding one or more guest molecules within their internal cavities. These hydrolysates are prepared by first converting amylopectin molecules from the double helix form to the single helix form and then by cleaving chain segments from the molecules.

    摘要翻译： 淀粉水解产物组合物特别适合用作螯合剂，即其易于与其它分子非共价相互作用形成稳定的包合物，其可用于各种应用。 作为螯合剂的组合物中的淀粉分子是与具有D.P.的淀粉分子的单螺旋包合物的形式。 约10至200，重均分子量D.P. 约10至50，作为在其内腔内保持一个或多个客体分子的宿主分子。 这些水解产物通过首先将支链淀粉分子从双螺旋形式转化为单螺旋形式，然后通过从分子切割链段来制备。

    LAYERED DOUBLE HYDROXIDES
    6.
    发明申请
    LAYERED DOUBLE HYDROXIDES 有权
    层状双羟基

    公开(公告)号：US20150258212A1

    公开(公告)日：2015-09-17

    申请号：US14433599

    申请日：2013-10-01

    申请人： OXFORD PHARMASCIENCE LIMITED

    发明人： Claire Thompson ,  Marcelo Leonardo Bravo Cordero ,  Dermot Michael O'Hare

    IPC分类号： A61K47/48 ,  A61K31/192

    CPC分类号： A61K47/48961 ,  A61K9/143 ,  A61K9/1611 ,  A61K31/192 ,  A61K47/52

    摘要： The invention relates to layered double hydroxide (LDH) materials and in particular to new methods of preparing improved LDH materials which have intercalated active anionic compounds (improved LDH-active anion materials). The improved LDH-active anion materials are characterised by their high degree of robustness, demonstrated by their high Particle Robustness Factor values, and by their ability to retain substantially all of the intercalated active anionic compound, in the absence of ion exchange conditions and/or at pH>4.

    摘要翻译： 本发明涉及层状双氢氧化物（LDH）材料，特别涉及制备具有插层的活性阴离子化合物（改进的LDH-活性阴离子材料）的改进的LDH材料的新方法。 改进的LDH活性阴离子材料的特征在于它们的高度稳定性，通过它们的高粒子稳健性因子值以及在不存在离子交换条件和/或不存在的情况下保留基本上所有插入的活性阴离子化合物的能力 在pH> 4。

    Dendrimer and an active substance occluded in the dendrimer, a process for the preparation thereof and a process for releasing the active substance
    8.
    发明授权
    Dendrimer and an active substance occluded in the dendrimer, a process for the preparation thereof and a process for releasing the active substance 失效
    树枝状聚合物中的树枝状聚合物和被遮挡的活性物质，其制备方法和释放活性物质的方法

    公开(公告)号：US5788989A

    公开(公告)日：1998-08-04

    申请号：US454026

    申请日：1995-05-30

    申请人： Johan F. G. A. Jansen ,  Egbert W. Meijer ,  Ellen M. M. De Brabander-Van Den Berg

    发明人： Johan F. G. A. Jansen ,  Egbert W. Meijer ,  Ellen M. M. De Brabander-Van Den Berg

    IPC分类号： A61K47/30 ,  A61K31/195 ,  A61K47/48 ,  C08G83/00 ,  A61K9/14

    CPC分类号： B82Y5/00 ,  A61K47/48961 ,  C08G83/003 ,  Y02P20/582 ,  Y10S424/16

    摘要： The invention relates to a dendrimer composition in which an effective number of the terminal functionalities are provided with blocking agents, and at least one active substance species is occluded in the dendrimer. A blocking agent is a sufficiently sterically sized compound which readily enters into a chemical bond with a terminal group of a dendrimer but which can also be split off from the dendrimer or can be modified without affecting the chemical structure of the dendrimer and the occluded active substance. The blocking agent can also be provided with a protecting group. The time and duration over which an active substance is released can be controlled. The invention also relates to a process for the preparation of such a composition and to a process for the controlled release of the active substance.

    摘要翻译： 本发明涉及一种树枝状大分子组合物，其中有效数目的末端官能团具有封闭剂，并且至少一种活性物质被遮盖在树状聚合物中。 封闭剂是足够空间尺寸的化合物，其容易与树枝状聚合物的末端基团进行化学键合，但也可以从树枝状聚合物分离，或者可以在不影响树枝状聚合物和封闭的活性物质的化学结构的情况下进行改性 。 封端剂也可以具有保护基。 可以控制释放活性物质的时间和持续时间。 本发明还涉及一种制备这种组合物的方法和用于控制释放活性物质的方法。