公开(公告)号：US20110094882A1

公开(公告)日：2011-04-28

申请号：US12606496

申请日：2009-10-27

申请人： Gavin MACFIE ,  Graeme WEBSTER ,  Marco F. CARDOSI ,  Christopher Philip LEACH ,  Steven SETFORD ,  Selwayan SAINI

发明人： Gavin MACFIE ,  Graeme WEBSTER ,  Marco F. CARDOSI ,  Christopher Philip LEACH ,  Steven SETFORD ,  Selwayan SAINI

IPC分类号： G01N33/50

CPC分类号： G01N27/3272 ,  G01N2035/00118

摘要： A test meter for use with a dual-chamber, multi-analyte test strip includes a test strip receiving module and a signal processing module. The test strip receiving module has a first electrical connector configured for contacting a first analyte contact pad of a first working electrode of the test strip; a second electrical connector configured for contacting a second analyte contact pad of a second working electrode of the test strip, a third electrical connector configured for contacting a first counter/reference contact pad of a first counter/reference electrode layer of the test strip, and a fourth electrical connector configured for contacting a second counter/reference contact pad of a second counter/reference electrode layer of the test strip. The signal processing module is configured to receive a first signal via the first electrical connector and the third electrical connector and employ the first signal for the determination of a first analyte (such as glucose) in a bodily fluid sample (for example, whole blood sample) applied to the dual-chamber, multi-analyte test strip. Moreover, the signal processing module is also configured to receive a second signal via the second electrical connector and fourth electrical connector and employ the second signal for the determination of a second analyte (e.g., a ketone analyte) in the bodily fluid sample applied to the dual-chamber, multi-analyte test strip. Furthermore, the third and fourth electrical contacts provide contact in an opposing manner.

摘要翻译： 用于双腔多分析物测试条的测试仪包括测试条接收模块和信号处理模块。 测试条接收模块具有第一电连接器，其被配置用于接触测试条的第一工作电极的第一分析物接触焊盘; 第二电连接器，其被配置用于接触测试条的第二工作电极的第二分析物接触焊盘;第三电连接器，其被配置用于接触测试条的第一计数器/参考电极层的第一计数器/参考接触焊盘，以及 第四电连接器，其被配置为接触测试条的第二计数器/参考电极层的第二计数器/参考接触焊盘。 信号处理模块被配置为经由第一电连接器和第三电连接器接收第一信号，并且采用第一信号来确定体液样品中的第一分析物（例如葡萄糖）（例如，全血样品 ）应用于双室多分析物测试条。 此外，信号处理模块还被配置为经由第二电连接器和第四电连接器接收第二信号，并且使用第二信号来确定施加到所述第二电连接器和第四电连接器的体液样品中的第二分析物（例如，酮分析物） 双室多分析物测试条。 此外，第三和第四电触点以相反的方式提供接触。

公开(公告)号：US20110162978A1

公开(公告)日：2011-07-07

申请号：US12692120

申请日：2010-01-22

申请人： Marco F. CARDOSI ,  Stephen Patrick Blythe ,  Matthew Finch ,  Arlene Thompson ,  Nina Antonia Naylor ,  Eric Jason Bailey ,  Michael Patrick Dolan ,  Gretchen Anderson ,  Lorraine Comstock ,  Mary Mcevoy ,  Thomas Sutton ,  Richard Michael Day ,  Leanne Mills ,  Emma Vanessa Jayne Day ,  Christopher Philip Leach

发明人： Marco F. CARDOSI ,  Stephen Patrick Blythe ,  Matthew Finch ,  Arlene Thompson ,  Nina Antonia Naylor ,  Eric Jason Bailey ,  Michael Patrick Dolan ,  Gretchen Anderson ,  Lorraine Comstock ,  Mary Mcevoy ,  Thomas Sutton ,  Richard Michael Day ,  Leanne Mills ,  Emma Vanessa Jayne Day ,  Christopher Philip Leach

IPC分类号： C12Q1/26 ,  G01N27/416 ,  C12Q1/54

CPC分类号： G01N27/3274

摘要： A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.

摘要翻译： 提供了一种方法和系统，用于确定基本上血细胞比容的独立分析物浓度。 在一个示例中，提供了包括测试条和测试仪的分析物测量系统。 测试条包括参考电极和工作电极，其中工作电极涂覆有试剂层。 测试仪包括电子电路和信号处理器。 电子电路在相应的持续时间内对参考电极和工作电极施加多个电压。 所述信号处理器被配置成确定来自多个电流值的分析物的基本上与血细胞比容无关的浓度，所述多个电流值在由静止电压施加多个测试电压至参考电极和工作电极的多个持续时间时由处理器测量 低于施加到电极的测试电压。

公开(公告)号：US20100273249A1

公开(公告)日：2010-10-28

申请号：US12429405

申请日：2009-04-24

申请人： Marco F. CARDOSI ,  Michael O'CONNELL

发明人： Marco F. CARDOSI ,  Michael O'CONNELL

IPC分类号： C12M1/00

CPC分类号： C12Q1/001 ,  C12Q1/006

摘要： An analytical test strip includes a substrate and a reagent layer disposed on a portion of the substrate. The reagent layer includes an enzymatic reagent ink comprising an amount of hydrophobic silica material, an amount of surfactant; and an amount of enzyme. The amounts of the hydrophobic silica material and the surfactant in the enzymatic reagent ink is predetermined using a first relationship and a second relationship. The first relationship is between wetability of a representative hydrophobic silica material and at least a first calibration characteristic of an analytical test strip that includes an enzymatic reagent ink containing the representative hydrophobic silica material. In addition, the first relationship defines a minimum wetability that provides an acceptable first calibration characteristic. The second relationship defines wetability of a mixture of the hydrophobic silica material and the surfactant across a range of relative amounts of the hydrophobic silica material and the surfactant. The predetermined amounts of the hydrophobic silica material and the surfactant employed in the enzymatic reagent ink provide at least the minimum wetability defined by the first relationship during manufacturing of the enzymatic reagent ink and, therefore, an acceptable first calibration characteristic.

摘要翻译： 分析测试条包括设置在基板的一部分上的基板和试剂层。 试剂层包括含有一定量的疏水性二氧化硅材料，一定量的表面活性剂的酶试剂油墨; 和一定量的酶。 使用第一关系和第二关系来预定酶试剂油墨中的疏水性二氧化硅材料和表面活性剂的量。 第一个关系是在代表性的疏水性二氧化硅材料的润湿性和至少包含含有代表性疏水性二氧化硅材料的酶试剂油墨的分析测试条的第一校准特性之间。 此外，第一关系定义了提供可接受的第一校准特性的最小可湿性。 第二关系定义了疏水性二氧化硅材料和表面活性剂的混合物在疏水性二氧化硅材料和表面活性剂的相对量的范围内的润湿性。 在酶试剂油墨中使用的预定量的疏水性二氧化硅材料和表面活性剂提供至少在酶试剂油墨的制造期间由第一关系定义的最小可湿性，因此提供可接受的第一校准特性。

公开(公告)号：US20100270152A1

公开(公告)日：2010-10-28

申请号：US12429393

申请日：2009-04-24

申请人： Marco F. CARDOSI ,  Michael O'CONNELL

发明人： Marco F. CARDOSI ,  Michael O'CONNELL

IPC分类号： C12Q1/54

CPC分类号： C12Q1/001 ,  C12Q1/006

摘要： An enzymatic reagent ink includes an amount of hydrophobic silica material (e.g., a fumed silica material), an amount of surfactant (such as a non-ionic surfactant); and an amount of enzyme (for example, glucose oxidase). The amounts of the hydrophobic silica material and the surfactant present in the enzymatic reagent ink is predetermined based on first and second relationships. The first relationship is a relationship between wetability of a representative hydrophobic silica material and a first calibration characteristic of an analytical test strip that includes an enzymatic reagent ink containing the representative hydrophobic silica material. In addition, such a first relationship defines a minimum wetability that provides an acceptable first calibration characteristic. The second relationship is a relationship defining wetability of a mixture of the hydrophobic silica material and a surfactant across a range of relative amounts of the hydrophobic silica material and the surfactant. The amounts of the hydrophobic silica material and the surfactant in the enzymatic reagent ink are predetermined to provide at least the minimum wetability defined by the first relationship during manufacturing of the enzymatic reagent ink, and therefore, an acceptable first calibration characteristic.

摘要翻译： 酶试剂油墨包括一定量的疏水性二氧化硅材料（例如热解二氧化硅材料），一定量的表面活性剂（如非离子表面活性剂）; 和一定量的酶（例如，葡萄糖氧化酶）。 基于第一和第二关系，预先确定存在于酶试剂油墨中的疏水性二氧化硅材料和表面活性剂的量。 第一个关系是代表性的疏水性二氧化硅材料的润湿性与包含含有代表性的疏水性二氧化硅材料的酶试剂油墨的分析试纸的第一校准特性之间的关系。 此外，这种第一关系定义了提供可接受的第一校准特性的最小可湿性。 第二关系是在疏水性二氧化硅材料和表面活性剂的相对量的范围内定义疏水性二氧化硅材料和表面活性剂的混合物的润湿性的关系。 在酶试剂油墨中的疏水性二氧化硅材料和表面活性剂的量被预先确定，以至少提供在酶试剂油墨的制造期间由第一关系定义的最小可湿性，因此可接受的第一校准特性。

公开(公告)号：US20100270151A1

公开(公告)日：2010-10-28

申请号：US12429376

申请日：2009-04-24

申请人： Marco F. CARDOSI ,  Michael O'Connell

发明人： Marco F. CARDOSI ,  Michael O'Connell

IPC分类号： C12Q1/26

CPC分类号： C12Q1/001

摘要： A method for manufacturing an enzymatic reagent ink for use in analytical test strips (such as electrochemical-based analytical test strips configured for the determination of glucose in blood) includes determining a first relationship between wetability of a representative hydrophobic silica material (e.g., a hydrophobic fumed silica material) and at least a first calibration characteristic (for example, a calibration slope) of an analytical test strip that includes an enzymatic reagent ink containing the representative hydrophobic silica material. In the method, the first relationship defines a minimum wetability that provides an acceptable first calibration characteristic. The method also includes determining a second relationship defining wetability of a mixture of a particular hydrophobic silica material and a particular surfactant across a range of relative amount of the particular hydrophobic silica material and the particular surfactant and, subsequently, combining an amount of the particular hydrophobic silica material, an amount of the particular surfactant, and an amount of enzyme (such as glucose oxidase) to form an enzymatic reagent ink. Moreover, the amounts of the particular hydrophobic silica material and the particular surfactant are predetermined based on the second relationship to provide at least the minimum wetability defined by the first relationship.

摘要翻译： 用于制造用于分析试片（例如，用于测定血液中的葡萄糖的基于电化学的分析测试条）的酶试剂油墨的方法包括确定代表性的疏水性二氧化硅材料（例如疏水性的）的可润湿性之间的第一关系 气相二氧化硅材料）和至少包含含有代表性疏水性二氧化硅材料的酶试剂油墨的分析测试条的第一校准特性（例如，校准斜率）。 在该方法中，第一关系定义了提供可接受的第一校准特性的最小可湿性。 该方法还包括确定特定疏水性二氧化硅材料和特定表面活性剂的混合物在特定疏水性二氧化硅材料和特定表面活性剂的相对量的范围内的润湿性的第二关系，并且随后将一定量的特定疏水性 二氧化硅材料，一定量的表面活性剂和一定量的酶（如葡萄糖氧化酶）以形成酶试剂油墨。 此外，特定疏水性二氧化硅材料和特定表面活性剂的量基于第二关系而预先确定，以至少提供由第一关系定义的最小可湿性。