公开(公告)号：US20220073652A1

公开(公告)日：2022-03-10

申请号：US17480707

申请日：2021-09-21

申请人： Gelesis LLC

发明人： Alessandro Sannino ,  Christian Demitri ,  Yishai Zohar ,  Eyal S. Ron ,  Barry J. Hand ,  Cosimo Saponaro

IPC分类号： C08B15/00 ,  A61K31/738 ,  A61K9/00 ,  A61K9/48

摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

公开(公告)号：US20220073651A1

公开(公告)日：2022-03-10

申请号：US17480571

申请日：2021-09-21

申请人： Gelesis LLC

发明人： Alessandro Sannino ,  Christian Demitri ,  Yishai Zohar ,  Barry J. Hand ,  Eyal S. Ron

IPC分类号： C08B3/12 ,  C08B11/12 ,  C08B11/08 ,  C08B11/20 ,  C08L1/08 ,  C08L1/28 ,  C08B15/00 ,  C08J3/075 ,  A61P3/04 ,  A23L33/24 ,  A61K31/738

摘要： The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.

公开(公告)号：US10098907B2

公开(公告)日：2018-10-16

申请号：US15494915

申请日：2017-04-24

申请人： Gelesis, LLC

发明人： Alessandro Sannino ,  Christian Demitri ,  Yishai Zohar ,  Eyal S. Ron ,  Barry J. Hand ,  Cosimo Saponaro

IPC分类号： A61K31/738 ,  A61K9/16 ,  A61K9/48 ,  A61K9/00 ,  A61K9/14

摘要： The present invention provides a method of treating constipation and compositions useful in said method. The method comprises administering to a subject in need thereof an effective amount of a crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids.

公开(公告)号：US20200277407A1

公开(公告)日：2020-09-03

申请号：US16812767

申请日：2020-03-09

申请人： GELESIS, LLC

发明人： Alessandro Sannino ,  Christian Demitri ,  Yishai Zohar ,  Eyal S. Ron ,  Barry J. Hand ,  Cosimo Saponaro

IPC分类号： C08B15/00 ,  A61K31/738 ,  A61K9/00 ,  A61K9/48

摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

公开(公告)号：US10584183B2

公开(公告)日：2020-03-10

申请号：US16220598

申请日：2018-12-14

申请人： GELESIS, LLC

发明人： Alessandro Sannino ,  Christian Demitri ,  Yishai Zohar ,  Eyal S. Ron ,  Barry J. Hand ,  Cosimo Saponaro

IPC分类号： C08B15/00 ,  A61K31/738 ,  A61K9/00 ,  A61K9/48

摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

公开(公告)号：US20190233545A1

公开(公告)日：2019-08-01

申请号：US16220598

申请日：2018-12-14

申请人： GELESIS, LLC

发明人： Alessandro Sannino ,  Christian Demitri ,  Yishai Zohar ,  Eyal S. Ron ,  Barry J. Hand ,  Cosimo Saponaro

IPC分类号： C08B15/00 ,  A61K9/48 ,  A61K31/738 ,  A61K9/00

CPC分类号： C08B15/005 ,  A61K9/0053 ,  A61K9/4866 ,  A61K31/738

摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

公开(公告)号：US20170304356A1

公开(公告)日：2017-10-26

申请号：US15494915

申请日：2017-04-24

申请人： Gelesis, LLC

发明人： Alessandro Sannino ,  Christian Demitri ,  Yishai Zohar ,  Eyal S. Ron ,  Barry J. Hand ,  Cosimo Saponaro

IPC分类号： A61K31/738 ,  A61K9/00 ,  A61K9/14 ,  A61K9/48

CPC分类号： A61K31/738 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/1617 ,  A61K9/4825

摘要： The present invention provides a method of treating constipation and compositions useful in said method. The method comprises administering to a subject in need thereof an effective amount of a crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids.

公开(公告)号：US10179824B2

公开(公告)日：2019-01-15

申请号：US15010626

申请日：2016-01-29

申请人： GELESIS, LLC

发明人： Alessandro Sannino ,  Christian Demitri ,  Yishai Zohar ,  Eyal S. Ron ,  Barry J. Hand ,  Cosimo Saponaro

IPC分类号： C08B15/00 ,  A61K31/738 ,  A61K9/00 ,  A61K9/48

摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

公开(公告)号：US11130824B2

公开(公告)日：2021-09-28

申请号：US16812767

申请日：2020-03-09

申请人： GELESIS, LLC

发明人： Alessandro Sannino ,  Christian Demitri ,  Yishai Zohar ,  Eyal S. Ron ,  Barry J. Hand ,  Cosimo Saponaro

IPC分类号： C08B15/00 ,  A61K31/738 ,  A61K9/00 ,  A61K9/48

摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

公开(公告)号：US20160222134A1

公开(公告)日：2016-08-04

申请号：US15010626

申请日：2016-01-29

申请人： GELESIS, LLC

发明人： Alessandro Sannino ,  Christian Demitri ,  Yishai Zohar ,  Eyal S. Ron ,  Barry J. Hand ,  Cosimo Saponaro

IPC分类号： C08B15/00 ,  A61K9/00 ,  A61K9/16 ,  A61K31/738

CPC分类号： C08B15/005 ,  A61K9/0053 ,  A61K9/4866 ,  A61K31/738

摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

摘要翻译： 本发明提供了在模拟胃液/水（1：8）和模拟肠液中溶胀时具有高弹性模量和高吸收能力的交联羧甲基纤维素。 本发明还提供了制备交联的羧甲基纤维素的方法，包含交联的羧甲基纤维素的组合物和使用交联的羧甲基纤维素的方法，例如用于治疗超重或肥胖或用于增强血糖控制。