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公开(公告)号：US20180289734A1
公开(公告)日：2018-10-11
申请号：US15944960
申请日：2018-04-04
申请人： GELESIS, LLC
摘要： The present invention relates to new methods for crosslinking a polysaccharide with a bifunctional poly(ethylene glycol). The invention further includes the polymer hydrogels which can be produced using these methods, compositions comprising the polymer hydrogels and methods of use thereof.
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公开(公告)号：US20220133771A1
公开(公告)日：2022-05-05
申请号：US17501142
申请日：2021-10-14
申请人： Gelesis LLC
发明人： Maria Rescigno , Alessandro Sannino , Yishai Zohar , Elaine Chiquette , Alessandra Silvestri , Christian Demitri
IPC分类号： A61K31/717 , A61K9/00 , A61P1/00 , A61K47/38 , A61K38/18
摘要： Compositions and methods are provided for treating a gut permeability-related disease or disorder comprising administering to the gastrointestinal tract of a subject in need thereof, a therapeutically effective amount of a hydrogel having an elastic modulus (G′) of at least about 500 Pa.
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公开(公告)号：US20220073652A1
公开(公告)日：2022-03-10
申请号：US17480707
申请日：2021-09-21
申请人： Gelesis LLC
发明人： Alessandro Sannino , Christian Demitri , Yishai Zohar , Eyal S. Ron , Barry J. Hand , Cosimo Saponaro
IPC分类号： C08B15/00 , A61K31/738 , A61K9/00 , A61K9/48
摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
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公开(公告)号：US20220073651A1
公开(公告)日：2022-03-10
申请号：US17480571
申请日：2021-09-21
申请人： Gelesis LLC
IPC分类号： C08B3/12 , C08B11/12 , C08B11/08 , C08B11/20 , C08L1/08 , C08L1/28 , C08B15/00 , C08J3/075 , A61P3/04 , A23L33/24 , A61K31/738
摘要： The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80° C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.
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公开(公告)号：US10098907B2
公开(公告)日：2018-10-16
申请号：US15494915
申请日：2017-04-24
申请人： Gelesis, LLC
发明人： Alessandro Sannino , Christian Demitri , Yishai Zohar , Eyal S. Ron , Barry J. Hand , Cosimo Saponaro
IPC分类号： A61K31/738 , A61K9/16 , A61K9/48 , A61K9/00 , A61K9/14
摘要： The present invention provides a method of treating constipation and compositions useful in said method. The method comprises administering to a subject in need thereof an effective amount of a crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids.
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公开(公告)号：US20230320384A1
公开(公告)日：2023-10-12
申请号：US17981620
申请日：2022-11-07
申请人： Gelesis, LLC
IPC分类号： A23L2/52 , A21D2/14 , A21D2/18 , A23G9/34 , A23L2/68 , C08B13/00 , C08B15/00 , C08J3/075 , C08L1/32 , A23L29/288 , A23L7/10 , A23L7/109 , A23L7/122 , A23L7/126 , A23L33/00 , A23L33/24 , A21D13/80
CPC分类号： A23L2/52 , A21D2/145 , A21D2/18 , A21D2/188 , A23G9/34 , A23L2/68 , C08B13/00 , C08B15/005 , C08J3/075 , C08L1/32 , A23L29/288 , A23L7/10 , A23L7/109 , A23L7/122 , A23L7/126 , A23L33/30 , A23L33/24 , A21D13/80 , A23V2002/00 , C08J2301/02 , C08J2301/10 , A61K47/38
摘要： The present invention provides methods, compositions and modified foods and foodstuffs useful for weight management and glycemic control.
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公开(公告)号：US20200277407A1
公开(公告)日：2020-09-03
申请号：US16812767
申请日：2020-03-09
申请人： GELESIS, LLC
发明人： Alessandro Sannino , Christian Demitri , Yishai Zohar , Eyal S. Ron , Barry J. Hand , Cosimo Saponaro
IPC分类号： C08B15/00 , A61K31/738 , A61K9/00 , A61K9/48
摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
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公开(公告)号：US10584183B2
公开(公告)日：2020-03-10
申请号：US16220598
申请日：2018-12-14
申请人： GELESIS, LLC
发明人： Alessandro Sannino , Christian Demitri , Yishai Zohar , Eyal S. Ron , Barry J. Hand , Cosimo Saponaro
IPC分类号： C08B15/00 , A61K31/738 , A61K9/00 , A61K9/48
摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
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公开(公告)号：US20190233545A1
公开(公告)日：2019-08-01
申请号：US16220598
申请日：2018-12-14
申请人： GELESIS, LLC
发明人： Alessandro Sannino , Christian Demitri , Yishai Zohar , Eyal S. Ron , Barry J. Hand , Cosimo Saponaro
IPC分类号： C08B15/00 , A61K9/48 , A61K31/738 , A61K9/00
CPC分类号： C08B15/005 , A61K9/0053 , A61K9/4866 , A61K31/738
摘要： The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.
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公开(公告)号：US10086014B2
公开(公告)日：2018-10-02
申请号：US15185443
申请日：2016-06-17
申请人： GELESIS LLC
IPC分类号： A61K31/765 , A61L15/22 , A61L15/28 , A61L15/60 , C08B11/20 , C08B15/00 , C08J3/24 , A23L29/262 , C08L1/28 , A61K9/06 , A61K47/38
摘要： The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.
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